A5060380911- Plant Molecular Biology Research
- Protein Structure and Dynamics
- Nonlinear Dynamics and Pattern Formation
- Plant Reproductive Biology
- Photosynthetic Processes and Mechanisms
- Plant nutrient uptake and metabolism
- Gene Regulatory Network Analysis
- Microbial Metabolic Engineering and Bioproduction
- Plant Stress Responses and Tolerance
- Hemoglobin structure and function
- Spectroscopy and Quantum Chemical Studies
- Light effects on plants
- stochastic dynamics and bifurcation
- Advanced Multi-Objective Optimization Algorithms
- Biofuel production and bioconversion
- Enzyme Catalysis and Immobilization
- Endoplasmic Reticulum Stress and Disease
- Metabolomics and Mass Spectrometry Studies
- Welding Techniques and Residual Stresses
- Surface Treatment and Residual Stress
- Chaos control and synchronization
- Weed Control and Herbicide Applications
- Glutathione Transferases and Polymorphisms
- Advanced Thermodynamics and Statistical Mechanics
- Simulation Techniques and Applications
Durham University
2014-2025
First People's Hospital of Chongqing
2024
ZheJiang Academy of Agricultural Sciences
2023
Xinxiang Medical University
2023
First Affiliated Hospital of Xinxiang Medical University
2023
Dalian Medical University
2023
Jiujiang University
2017-2022
Jilin University
2019
Inner Mongolia University
2018
University of Oxford
2004-2018
Summary Understanding the mechanisms regulating root development under drought conditions is an important question for plant biology and world agriculture. We examine effect of osmotic stress on abscisic acid (ABA), cytokinin ethylene responses how they mediate auxin transport, distribution growth through effects PIN proteins. integrate experimental data to construct hormonal crosstalk networks formulate a systems view regulation by multiple hormones. Experimental analysis shows: that ABA...
Abstract To cope with oxidative stress, the metabolic network of plant cells must be reconfigured either to bypass damaged enzymes or support adaptive responses. characterize dynamics change during heterotrophic Arabidopsis (Arabidopsis thaliana) were treated menadione and changes in metabolite abundance 13C-labeling kinetics quantified a time series samples taken over 6 h period. Oxidative stress had profound effect on central pathways extensive inhibition radiating from tricarboxylic acid...
Silver nanoparticles (AgNPs) are extensively utilized in industrial, biotechnological and medical fields because of their specific physical chemical properties, which shown small size effects, surface interface quantum scale effects. Inevitably, wastewater containing AgNPs is leached into the soil. soil may be absorbed by plant roots they affect growth. Understanding complex interactions between plants crucial significance since essential to ecological environment as key players ecosystems....
Summary Metabolic pathways of primary metabolism discs isolated from potato tubers were evaluated by the use a gas chromatography‐mass spectrometry (GC‐MS) method generated specifically for this purpose. After testing several possible methods including chemical ionization, it was decided reasons sensitivity, reproducibility and speed to electron impact ionization‐based GC‐MS analysis. The specific labelling label accumulation over 30 metabolites broad number sugars, organic amino acids...
Understanding how hormones and genes interact to coordinate plant growth is a major challenge in developmental biology. The activities of auxin, ethylene cytokinin depend on cellular context exhibit either synergistic or antagonistic interactions. Here we use experimentation network construction elucidate the role interaction POLARIS peptide (PLS) auxin efflux carrier PIN proteins crosstalk three (auxin, cytokinin) Arabidopsis root development. In hypersignalling mutants such as polaris...
Summary Patterning in Arabidopsis root development is coordinated via a localized auxin concentration maximum the tip, requiring regulated expression of specific genes. However, little known about how hormone and gene patterning generated. Using variety experimental data, we develop spatiotemporal hormonal crosstalk model that describes integrated action auxin, ethylene cytokinin signalling, POLARIS protein, functions PIN AUX 1 transporters. We also conduct novel experiments to confirm our...
Many mathematical models have now been employed across every area of systems biology. These increasingly involve large numbers unknown parameters, complex structure which can result in substantial evaluation time relative to the needs analysis, and need be compared observed data various forms. The correct analysis such usually requires a global parameter search, over high dimensional space, that incorporates respects most important sources uncertainty. This an extremely difficult task, but...
Summary Calcium plays a key role in determining the specificity of vast array signalling pathways plants. Cellular calcium elevations with different characteristics (calcium signatures) carry information on identity primary stimulus, ensuring appropriate downstream responses. However, mechanism for decoding signatures is unknown. To determine this, salicylic acid ( SA )‐mediated plant immunity network controlling gene expression was examined. A dynamic mathematical model ‐mediated developed....
Polyamines (PAs) dramatically affect root architecture and development, mainly by unknown mechanisms; however, accumulating evidence points to hormone signaling reactive oxygen species (ROS) as candidate mechanisms. To test this hypothesis, PA levels were modified progressively reducing ADC1/2 activity Put levels, then changes in meristematic zone (MZ) size, ROS, auxin cytokinin (CK) investigated. Decreasing putrescine resulted an interesting inverted-U-trend primary growth a similar trend...
Summary Experimental data show that Arabidopsis thaliana is able to decode different calcium signatures produce specific gene expression responses. It also known calmodulin‐binding transcription activators ( CAMTA s) have calmodulin (CaM)‐binding domains. Therefore, the responses regulated by s respond signals. However, little about how are decoded A dynamic model of Ca 2+ –CaM– binding and developed following thermodynamic kinetic principles. The parameterized using experimental data. Then...
Sexual reproduction in higher plants relies upon the polarised growth of pollen tubes. The growth-site at tube tip responds to signalling processes successfully steer an ovule. Essential features are polarisation ion fluxes, intracellular gradients, and oscillating dynamics. However, little is known about how these generated they causally related. We propose that dynamics biological systems should be studied integrative self-regulatory way. Here we have developed a two-compartment model by...
The second messenger calcium plays a key role in conveying specificity of signaling pathways plant cells. Specific signatures are decoded to generate correct gene expression responses and amplification is vital this process. (1) It not known if an intrinsic property all calcium-regulated whether have the potential be amplified, or (2) how given signature maintains cells containing great number transcription factors (TFs) other proteins with calcium-regulated. work presented here uncovers...