A5056298040- Genetic Associations and Epidemiology
- Health, Environment, Cognitive Aging
- Air Quality and Health Impacts
- Nutritional Studies and Diet
- Liver Disease Diagnosis and Treatment
- Climate Change and Health Impacts
- Obesity, Physical Activity, Diet
- Diet, Metabolism, and Disease
- Diabetes and associated disorders
- Diet and metabolism studies
- Adipokines, Inflammation, and Metabolic Diseases
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Health disparities and outcomes
- Noise Effects and Management
- Lipid metabolism and disorders
- Obesity and Health Practices
- Endoplasmic Reticulum Stress and Disease
- Lipoproteins and Cardiovascular Health
- Phytochemicals and Medicinal Plants
- Metabolomics and Mass Spectrometry Studies
- Calpain Protease Function and Regulation
- Folate and B Vitamins Research
- Birth, Development, and Health
- Urban Transport and Accessibility
- Regulation of Appetite and Obesity
Utrecht University
2022-2024
Leiden University Medical Center
2018-2022
National Institute for Public Health and the Environment
2020-2022
Vrije Universiteit Amsterdam
2019-2021
Amsterdam University Medical Centers
2019
Harvard University
2016
Boston Children's Hospital
2016
OBJECTIVE Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work, we investigated the genetic basis of this heterogeneity by clustering 94 T2D loci using their associations with 47 diabetes-related traits identified five clusters, termed β-cell, proinsulin, obesity, lipodystrophy, liver/lipid. The relationship between these clusters individual-level metabolic disease outcomes not been assessed. RESEARCH DESIGN AND METHODS Here constructed...
Background We evaluated the independent and joint effects of air pollution, land/built environment characteristics, ambient temperature on all-cause mortality as part EXPANSE project. Methods collected data from six administrative cohorts covering Catalonia, Greece, Netherlands, Rome, Sweden, Switzerland three traditional in Germany. Participants were linked to spatial exposure estimates derived hybrid land use regression models satellite for: pollution [fine particulate matter (PM 2.5 ),...
Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) and untargeted metabolomics are increasingly used in exposome studies study the interactions between nongenetic factors blood metabolome. To reliably efficiently link detected compounds exposures health phenotypes such studies, it is important understand variability metabolome measures. We assessed within- between-subject of LC-HRMS measurements 298 nonfasting human serum samples collected on two occasions from 157...
Socioeconomic inequalities in the exposome have been found to be complex and highly context-specific, but studies not conducted large population-wide cohorts from multiple countries. This study aims examine external exposome, encompassing individual environmental factors influencing health over life course, perform dimension reduction derive interpretable characterization of for multicountry epidemiological studies. Analyzing data 25 million individuals across seven European countries...
Abstract Purpose In this study, we investigated the association between adherence to Dutch Healthy Diet index 2015 (DHD15-index) and incidence of prediabetes (preT2D) Type 2 Diabetes (T2D) in a representative sample for general population. Methods Two prospective cohort studies, The Hoorn New Study, were used data analyses. total, from 2951 participants without diabetes at baseline (mean age 56.5 ± 7.5 years; 49.6% male) harmonized. Baseline dietary intake was assessed with validated Food...
Mendelian randomization studies have shown that triglyceride (TG)- lowering lipoprotein lipase (LPL) alleles and low-density lipoprotein-cholesterol (LDL-C)-lowering independent beneficial associations on cardiovascular disease (CVD) risk. We aimed to provide further insight into this observation by applying analyses of genetically-influenced TG LDL-C levels plasma metabolomic profiles.We quantified over 100 measures in the Netherlands Epidemiology Obesity (NEO) study (N = 4838) Oxford...
Triglyceride (TG)-lowering LPL variants in combination with genetic LDL-C-lowering are associated reduced risk of coronary artery disease (CAD). Genetic variation the APOA5 gene encoding apolipoprotein A-V also strongly affects TG levels, but potential clinical impact and underlying mechanisms yet to be resolved. Here, we aimed study effects on CAD plasma lipoproteins through factorial association analyses. Using data from 309,780 European-ancestry participants UK Biobank, evaluated lower...
Background Many studies reported associations between long-term exposure to environmental factors and mortality; however, little is known on the combined effects of these health. We aimed evaluate association external exposome all-cause mortality in large administrative traditional adult cohorts Europe. Methods Data from six (Catalonia, Greece, Rome, Sweden, Switzerland Netherlands, totaling 27,913,545 subjects) three (CEANS-Sweden, EPIC-NL-the KORA–Germany, 57,653 participants) were...
The increase in serum triglyceride (TG) concentrations response to a meal is considered risk factor for cardiovascular disease. We aimed elucidate the genetics of postprandial TG through genome-wide association studies (GWAS).Participants NEO (Netherlands Epidemiology Obesity) study (n=5630) consumed liquid mixed after an overnight fast. GWAS fasting and at 150 minutes were performed. To identify genetic variation independent TG, we calculated by residuals nonlinear regression that predicted...
Abstract Cognitive decline is part of the normal aging process. However, some people experience a more rapid than others due to environmental and genetic factors. Numerous single nucleotide polymorphisms (SNPs) have been linked cognitive function, but only few decline. To understand whether function are driven by same mechanisms, we investigated 433 SNPs previously 2 associated with both general functioning at baseline up 20-years follow-up in Doetinchem Cohort Study (DCS). The DCS...
Abstract Objective Obesity is becoming a global public health problem, but it unclear how impacts different generations over the life course. Here, descriptive analysis of age‐related changes in anthropometric measures and related cardiometabolic risk factors across was performed. Methods The development studied during 26 years follow‐up Doetinchem Cohort Study ( N = 6,314 at baseline). All analyses were stratified by sex generation, i.e., 10‐year age groups (20‐29, 30‐39, 40‐49, 50‐59...
<a><i>Objective</i>: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work we investigated the genetic basis of this heterogeneity by clustering 94 T2D loci using their associations with 47 diabetes-related traits identified five clusters: Beta cell, Proinsulin, Obesity, Lipodystrophy, Liver/Lipid. The relationship between these clusters individual-level metabolic disease outcomes not been assessed. </a>...
<a><i>Objective</i>: Type 2 diabetes (T2D) has heterogeneous patient clinical characteristics and outcomes. In previous work we investigated the genetic basis of this heterogeneity by clustering 94 T2D loci using their associations with 47 diabetes-related traits identified five clusters: Beta cell, Proinsulin, Obesity, Lipodystrophy, Liver/Lipid. The relationship between these clusters individual-level metabolic disease outcomes not been assessed. </a>...
Background EXPANSE collects multiple European cohorts data and applies standardized protocols for exposure assessment to investigate urban exposome effects on health. We evaluated associations of environmental stressors all-cause mortality in adult administrative Greece, Rome, Switzerland, Catalonia, Sweden the Netherlands. Methods linked exposures geocoded residential addresses >20.9million participants followed between 2011 2019 including to:PM2.5, NO2, BC, warm season O3, NDVI, distance...
Background and Aim: Multiple environmental factors of urban environments may influence cardiovascular health, however their complex interplay has scarcely been studied. Within the EXPANSE project, we evaluated association between multiple exposures stroke incidence across Europe. Methods: We will conduct a meta-analysis including 3 population-based cohorts (from Sweden, Netherlands, Germany) 6 administrative Greece, Rome, Catalonia, Switzerland, Netherlands). Participants were followed-up...
The original version of this article unfortunately contained a mistake in Table 4.