A5113906520- Fungal Biology and Applications
- Microbial Natural Products and Biosynthesis
- Asthma and respiratory diseases
- Plant Pathogens and Fungal Diseases
- Phytochemical Studies and Bioactivities
- Chromatography in Natural Products
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Chemical synthesis and alkaloids
- Psoriasis: Treatment and Pathogenesis
- Acute Myeloid Leukemia Research
- Cytokine Signaling Pathways and Interactions
- Plant and fungal interactions
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Angiogenesis and VEGF in Cancer
- Cell death mechanisms and regulation
- Translation Studies and Practices
- IL-33, ST2, and ILC Pathways
- Respiratory Support and Mechanisms
- Histiocytic Disorders and Treatments
- Pesticide Residue Analysis and Safety
- Antifungal resistance and susceptibility
- Cancer-related molecular mechanisms research
- Power Systems and Technologies
- Pediatric health and respiratory diseases
- Microbial Metabolism and Applications
China Agricultural University
2010-2024
Second Affiliated Hospital of Jilin University
2013-2024
Fudan University
2012-2024
Huadong Hospital
2020-2024
China Three Gorges University
2022-2023
Yichang Central People's Hospital
2023
Hunan Provincial People's Hospital
2021-2023
Hunan Normal University
2021-2023
Shaanxi University of Chinese Medicine
2023
Chinese Academy of Medical Sciences & Peking Union Medical College
2019-2022
Plant endophytic fungi are an important and novel resource of natural bioactive compounds with their potential applications in agriculture, medicine food industry. In the past two decades, many valuable antimicrobial, insecticidal, cytotoxic, anticancer activities have been successfully discovered from fungi. During long period co-evolution, a friendly relationship was formed between each endophyte its host plant. Some endophytes ability to produce same or similar as those originated plants....
Three steroids and one nordammarane triterpenoid were isolated for the first time from endophytic fungus Pichia guilliermondii Ppf9 derived medicinal plant Paris polyphylla var. yunnanensis. By means of physicochemical spectrometric analysis, they identified as ergosta-5,7,22-trienol (1), 5α,8α-epidioxyergosta-6,22-dien-3β-ol (2), ergosta-7,22-dien-3β,5α,6β-triol (3), helvolic acid (4). Both micro-dilution-colorimetric spore germination assays employed to evaluate their antimicrobial...
Seven flavonoids have been isolated from the aerial parts of Halostachys caspica C. A. Mey. (Chenopodiaceae) for first time. By means physicochemical and spectrometric analysis, they were identified as luteolin (1), chrysin (2), 7-O-β-D-glucopyranoside (3), quercetin (4), 3-O-β-D-glucopyranoside (5), isorhamentin-3-O-β-D-glucopyranoside (6), isorhamentin-3-O-β-D-rutinoside (7). All evaluated to show a broad antimicrobial spectrum activity on microorganisms including seven bacterial one...
Background To determine the global burden of psoriasis in young adults, i.e., those aged 15–49, from 1990 to 2019 and predict trends this for 2020 2030 Methods Age-standardized disease indicators their estimated annual percentage changes were assessed used compare between regions. In addition, generalized additive models population 2030. Results From 2019, overall adults worldwide trended downward, as age-standardized incidence rate disability-adjusted life year decreased. there gender...
Four diterpenoid tanshinones and three phenolic acids were isolated from the crude ethanol extract of cultured hairy roots Salvia miltiorrhiza Bunge by bioassay-guided fractionation. By means physicochemical spectrometric analysis, they identified as tanshinone ΙΙA (1), Ι (2), cryptotanshinone (3), dihydrotanshinone (4), rosmarinic acid (5), caffeic (6), danshensu (7). These compounds evaluated to show a broad antimicrobial spectrum activity on test microorganisms including eight bacterial...
Nine new spirobisnaphthalenes, palmarumycins B1-B9 (1-9), along with 13 known compounds (10-22), were isolated from cultures of the fungus Berkleasmium sp., an endophyte medicinal plant Dioscorea zingiberensis C. H. Wright. The structures elucidated by analysis 1D and 2D NMR HRESIMS spectra comparison compounds. Compounds 7-9 contain uncommon 2,3-dihydro-1H-inden-1-one unit. All evaluated for their antibacterial activities against Bacillus subtilis, Staphylococcus hemolyticus, Agrobacterium...
The global, regional, and national burden of psoriasis was investigated based on the Global Burden Disease (GBD) study. To report incidence in 204 countries territories from 21 regions according to age, sex, region, country, socialdemographic index (SDI) between 1990 2019. Estimates GBD 2019 study were used analyse at levels. estimated annual percentage changes (EAPCs) age-standardized rate (ASIR) calculated quantify trends From 2019, global increased by 26.53%, but ASIR decreased, with an...
Rationale: Neurofibromatosis is an autosomal dominant genetic disorder characterized by developmental abnormalities of the nervous system, skin, and bones. Clinically, it relatively rare often associated with various benign malignant tumors. Patient concerns: However, reports its association melanoma are scarce, has been reported as a case report in this study. Case treatment options discussed below. Diagnoses: A 71-year-old male presented long-standing skin nodules plaques including growing...
Three polysaccharides, namely exopolysaccharide (EPS), water-extracted mycelial polysaccharide (WPS) and sodium hydroxide-extracted (SPS), were prepared from the endophytic fungus Fusarium oxysporium Dzf17 isolated rhizomes of Dioscorea zingiberensis. The effects time addition concentration on growth diosgenin accumulation in cell suspension culture D. zingiberensis studied. Among them, WPS was found to be most effective polysaccharide. When added medium at 20 mg/L 25th day culture, dry...
The effects of the oligosaccharides from endophytic fungus Fusarium oxysporum Dzf17 as elicitors on diosgenin production in cell suspension cultures its host Dioscorea zingiberensis were investigated. Three oligosaccharides, DP4, DP7 and DP10, purified oligosaccharide fractions DP2-5, DP5-8 DP8-12, respectively, which prepared water-extracted mycelial polysaccharide F. Dzf17. When treated with fraction at 20 mg/L day 26 harvested 32, maximum yield (2.187 mg/L) was achieved, 5.65-fold control...
Two spirobisnaphthalenes, namely palmarumycins C2 and C3, were isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. After addition 1-hexadecene at 10% to medium on day 6 culture, maximal yields C3 obtained as 0.40 g/L 1.19 g/L, which 40.00 fold 59.50 higher, respectively, in comparison those control (0.01 0.02 g/L). The results indicated that can be an effective strategy for enhancing production liquid culture Dzf12. Palmarumycin exhibited...
This study explored the effects of microRNA-19b (miR-19b) on airway remodeling, inflammation, and degree oxidative stress in a mouse model asthma. Bioinformatics analyses dual luciferase reporter gene assays revealed that thymic stromal lymphopoietin (TSLP) is direct target miR-19b. An asthma was established via ovalbumin (OVA) sensitization challenge 72 female BALB/c mice. Mice were then assigned to saline, OVA-sensitized, saline+miR-19b mimics, saline+anti-TSLP, OVA-sensitized+miR-19b...
Currently, paclobutrazol is excessively used in the planting process of Ophiopogon japonicus (O. japonicus) due to its important role regulating growth tuber roots, ultimately increasing yield and shortening cycle Ophiopogonis Radix. For insight into this potential risks mediated consequences on secondary metabolites Radix, corresponding high performance liquid chromatography-tandem mass spectrometric methods (HPLC-MS/MS) were developed study then applied soil, water samples. The results...
Abstract Background More and more azole-resistant strains emerged through the development of acquired resistance an epidemiological shift towards inherently less susceptible species. The mechanisms azoles Candida albicans is very complicated. In this study, we aim to investigate mechanism C. isolated from oral cavity a patient with chronic mucocutaneous candidiasis (CMC). Case presentation CMC diagnosis was given based on clinical manifestations, laboratory test findings gene sequencing...
Water-extracted mycelial polysaccharide (WPS) from the endophytic fungus Fusarium oxysporum Dzf17 isolated Dioscorea zingiberensis was found to be an efficient elicitor enhance diosgenin accumulation in D. zingigerensis cultures, and also demonstrated antioxidant activity. In this study, response surface methodology (RSM) employed optimize extraction process of WPS F. using Box-Behnken design (BBD). The ranges factors investigated were 1–3 h for time (X1), 80–100 °C temperature (X2), 20–40...
Background Anxiety is common in patients with chronic obstructive pulmonary disease (COPD), especially older the definition of age over 60 years old. Few studies have focused on anxiety COPD patients. This study aimed to analyze risk factors and impacts future acute exacerbation. Methods The general information, questionnaire data, previous exacerbation function were collected. Hamilton Rating Scale (HAMA) was used evaluate followed up for one year, number degrees exacerbations recorded....
To the Editor: Chronic obstructive pulmonary disease (COPD) is a common among elderly, affecting over one-third of elderly population worldwide. The progressive decline in lung function characteristic COPD significantly impacts quality life and employability affected individuals, resulting substantial direct indirect socioeconomic burden. frequently has comorbidities involving other organ systems. Virtually all patients present with one or more comorbid conditions, collectively exacerbating...
Berkleasmium sp. Dzf12, an endophytic fungus from Dioscorea zingiberensis, is a high producer of spirobisnaphthalenes with various bioactivities. The exopolysaccharide (EPS) produced by this also shows excellent antioxidant activity. In study, the experimental designs based on statistics were employed to evaluate and optimize medium for EPS production in liquid culture Dzf12. For increasing yield, concentrations glucose, peptone, KH(2)PO(4), MgSO(4)·7H(2)O FeSO(4)·7H(2)O optimized using...
Osteoporosis is a result of impaired bone formation and/or excessive resorption. Osteoclasts are the only cells in body that have resorption function. Inhibiting osteoclast activity and differentiation way to treat osteoporosis. The current pharmacological treatment for osteoporosis has many shortcomings, more effective treatments needed. Vinpocetine (Vinp), derivative alkaloid vincamine, been used cerebrovascular disorders cognitive impairment long time. Vinp inhibits mitogen-activated...