A5101417739- Bone Metabolism and Diseases
- Orthopaedic implants and arthroplasty
- Orthopedic Infections and Treatments
- Geology and Paleoclimatology Research
- T-cell and B-cell Immunology
- Total Knee Arthroplasty Outcomes
- Bone fractures and treatments
- Sarcoma Diagnosis and Treatment
- Immune Response and Inflammation
- Cancer Immunotherapy and Biomarkers
- earthquake and tectonic studies
- Cytokine Signaling Pathways and Interactions
- Spinal Fractures and Fixation Techniques
- TGF-β signaling in diseases
- Macrophage Migration Inhibitory Factor
- Hip and Femur Fractures
- Dietary Effects on Health
- Marine and coastal ecosystems
- NF-κB Signaling Pathways
- S100 Proteins and Annexins
- Soil and Water Nutrient Dynamics
- Spinal Cord Injury Research
- Cervical and Thoracic Myelopathy
- Nerve injury and regeneration
- Urologic and reproductive health conditions
Ocean University of China
2023
Nanjing University
2016-2022
Nanjing General Hospital of Nanjing Military Command
2011-2022
Jinling Institute of Technology
2012-2019
Second Affiliated Hospital of Nanjing Medical University
2016
Second Military Medical University
2016
Tianjin Medical University
2015
Second Hospital of Tianjin Medical University
2015
Qingdao University
1997
Summary Bone fractures may result in delayed union ( DU ) or non‐union NU some patients. Evidence suggests that the skewing of immune system toward proinflammatory type is a contributing factor. Because B cells were previously found to infiltrate fracture healing site at abundant levels, we examined regulatory (Bregs) / In bone patients with normal healing, frequency interleukin IL )‐10‐expressing was significantly upregulated early process (6 weeks post‐surgery) and downregulated later on...
The transforming growth factor-beta (TGF-β) signaling pathway plays critical roles in the development of various diseases. current study investigated whether TGF-β was involved pathogenesis osteosarcoma from genetic polymorphism perspective and serum level perspective. We first examined two TGF-β1 polymorphisms, rs1800469C/T rs1800470T/C, 202 patients 216 healthy controls. Data revealed that prevalence rs1800470TT genotype T allele significantly elevated than controls (odds ratio [OR]=2.28,...
Signal transducer and activator of transcription 3 (STAT3) is a key signaling protein in the skeletal system as well immune system. Accumulating evidence demonstrates that inflammatory response deeply involved healing process bone fractures, but how regulated during this unclear. In study, we examined STAT3-mediated regulation immunity adult patients with closed tibia fracture. all patients, expression activation STAT3 peaked at around day 7 to 14 after surgery, gradually decreased rest...
The development of Ewing's sarcoma (ES) is a complex process, resulting from interplay between mutations in oncogenes and tumor suppressors, host susceptibility factors, cellular context. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles downregulating the T-cell activation. Polymorphisms CTLA-4 gene have been shown to be associated with different autoimmune diseases cancers. current study evaluated association two polymorphisms, −318C/T (rs5742909) +49G/A (rs231775) ES Chinese...
Background . To compare the salvage rate and complication between internal fixation external in patients with small bone defects caused by chronic infectious osteomyelitis debridement. Methods 125 of tibia fracture who underwent multiple irrigation, debridement procedure, local/systemic antibiotics were enrolled. Bone defects, which less than 4 cm, treated grafting using either or monolateral fixation. 12-month follow-up was conducted an interval 3 months to evaluate union defect. Results...
Summary Bone fracture healing is a multistage regenerative process that requires the collaboration of various cell types, with approximately 5%‐10% fractures not properly. Accumulating evidence suggests dysregulations in immune system are associated defective healing. In cohort 30 bone patients between 50 and 62 years age, 8 displayed delayed Compared to 22 normal patients, these presented significantly lower frequencies CD 4 + 25 hi Foxp3 canonical regulatory T cells immediately following...
Objective: Promoting bone regeneration and repairing in defects is of great significance clinical work. Using a simple effective surface treatment method to enhance the osteogenic ability existing scaffold promising method. In this article, we study application catecholic amino acid 3,4-dihydroxyphenylalanine (DOPA) coating chelated with vascular endothelial growth factor (VEGF) on allogeneic bone. Method: Allogeneic immersed DOPA solution form polydopamine (PDA) good adhesion. Electron...
Background: To compare the risk of type 2 diabetes (T2DM) between patients with and without chronic osteomyelitis (COM), both in humans mice, to explore factors COM who developed T2DM.Methods: One hundred seven 114 were consecutively enrolled retrospectively analysed.Clinical data concerning time develop diabetes, glucose metabolism, lipid inflammatory factors, mental health frequency specialist visits collected.A mouse model was used verify presence impaired metabolism depression.All...
The pelvic ring fractures (PRF) are commonly induced by the high-energy impact and will lead to unstable sever injures. This study is aimed explore stability of anterior external fixation in treating pelvis fracture evaluate possibility for these kinds patients reduce bedridden time.A patient with Tile B3 was chosen research corresponding digital model reconstructed according CT images 3D scanning. Four angles under vertical compression were employed finite element (FE) analyses. stress...
Wear-induced aseptic loosening has been accepted as one of the main reasons for failure total hip arthroplasty. Ceramic wear debris is generated following prosthesis implantation and plays an important part in upregulation inflammatory factors The present study investigates influence ceramic on osteoblasts factors.Ceramic was prepared by mechanical grinding aluminum femoral head added to cultures MC3T3-E subclone 14 cells at different concentrations (i.e. 0, 5, 10, 15 μg/mL). Cell...
Traumatic spinal cord injury (SCI) happens accidently and often leads to motor dysfunction due a series of biochemical pathological events damage, either temporarily or permanently. Translocator protein 18 (TSPO) has been found be involved in the synthesis endogenous neurosteroids which have multiple effects on neurons, but internal mechanisms are not clear. N-benzyl-N-ethyl-2-(7,8-oxo-2-phenyl-9H-purin-9-yl) acetamide (ZBD-2), newly reported ligand TSPO, shows some neuroprotective effect...
The lymphocyte activation gene 3 (LAG-3) is a CD4 homolog with binding affinity to MHC class II molecules. It thought that LAG-3 exerts bimodal function, such co-ligation of and CD3 could deliver an inhibitory signal in conventional T cells, whereas, on regulatory expression promote their function. In this study, we investigated the role CD4+ cells patients long bone fracture. We found LAG-3+ represented approximately 13% peripheral blood average. Compared LAG-3− presented significantly...
Kuroshio Current (KC) plays a significant role in global climate change by transporting high-temperature and high-salinity water from low-latitude to mid-high-latitude waters. However, the KC evolution its main controlling factors remained unclear on orbital timescales. Here, we research comprehensive records of high-resolution terrigenous mass accumulation rate (MAR), grain size, Sr-Nd isotopic compositions clay-size fractions clay mineral assemblages core SCS0003 sediments northern slope...