A5101427969- interferon and immune responses
- Immune cells in cancer
- Immune Response and Inflammation
- Model-Driven Software Engineering Techniques
- Ubiquitin and proteasome pathways
- DNA Repair Mechanisms
- RNA modifications and cancer
- Liver Disease Diagnosis and Treatment
- SARS-CoV-2 and COVID-19 Research
- RNA Research and Splicing
- Genetics and Plant Breeding
- Biomarkers in Disease Mechanisms
- Cytokine Signaling Pathways and Interactions
- RNA and protein synthesis mechanisms
- Software Testing and Debugging Techniques
- Phagocytosis and Immune Regulation
- Plant Genetic and Mutation Studies
- Software Engineering Techniques and Practices
- Genetic Mapping and Diversity in Plants and Animals
- Thyroid Cancer Diagnosis and Treatment
- Cancer-related gene regulation
- PARP inhibition in cancer therapy
- Liver physiology and pathology
- Epigenetics and DNA Methylation
- Macrophage Migration Inhibitory Factor
Second Hospital of Anhui Medical University
2024
Anhui Medical University
2024
Stockholm University
2021-2023
Anhui University of Traditional Chinese Medicine
2023
Umeå University
2019-2022
Nanjing University
2011-2022
Nanjing Medical University
2022
Nanjing General Hospital of Nanjing Military Command
2017-2019
University of Michigan
2017
Fudan University Shanghai Cancer Center
2016
Unlike maize and wheat, where artificial selection is associated with an almost uniform increase in seed or grain size, domesticated rice exhibits dramatic phenotypic diversity for size shape. Here we clone characterize GS3, evolutionarily important gene controlling rice. We show that GS3 highly expressed young panicles both short- long-grained varieties but not leaves after flowering, use genetic transformation to demonstrate the dominant allele short complements long-grain phenotype. An...
The microbiota are vital for immune homeostasis and provide a competitive barrier to bacterial fungal pathogens. Here, we investigated how gut commensals modulate systemic immunity response viral infection. Antibiotic suppression of the reduced tonic type I interferon (IFN-I) antiviral priming. microbiota-driven IFN-I-response was dependent on cGAS-STING but not TLR signaling or direct host-bacteria interactions. Instead, membrane vesicles (MVs) from extracellular bacteria activated...
Article23 September 2019Open Access Source DataTransparent process Chromatin-bound cGAS is an inhibitor of DNA repair and hence accelerates genome destabilization cell death Hui Jiang orcid.org/0000-0003-1170-0224 The Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå Centre Microbial Research (UCMR), University, Umeå, Search more papers by this author Xiaoyu Xue Department Biophysics Biochemistry, Yale University School Medicine, New Haven, CT, USA Chemistry Texas State San...
Abstract Signaling by viral nucleic acids and subsequently type I IFN is central to antiviral innate immunity. These signaling events are also likely engage metabolic changes in immune nonimmune cells support defense. In this study, we show that cytosolic recognition, way of secondary signaling, leads upregulation glycolysis preferentially macrophages. This switch involves induction glycolytic activator 6-phosphofructose-2-kinase fructose-2,6-bisphosphatase (PFKFB3). Using a genetic...
Severe acute respiratory syndrome coronavirus 2 (SARS–CoV–2) has led to the disease 2019 (COVID–19) pandemic, severely affecting public health and global economy. Adaptive immunity plays a crucial role in fighting against SARS–CoV–2 infection directly influences clinical outcomes of patients. Clinical studies have indicated that patients with severe COVID–19 exhibit delayed weak adaptive immune responses; however, mechanism by which impedes remains unclear. Here, using an vitro cell line, we...
Malignant fibrous histiocytoma amplified sequence 1 (MFHAS1) is a predicted oncoprotein that demonstrates tumorigenic activity in vivo; however, the mechanisms involved are unknown. Macrophages divided into pro-inflammatory M1 and anti-inflammatory/protumoral M2 subtypes. Tumor cells can induce polarization of tumor-associated macrophages (TAMs) to promote metastasis; but underlying pathways require be elucidated. In this study, we detected positive association between MFHAS1 expression TAMs...
One of the most important reasons underlying resistance tumors is immune suppression induced by cancer cells. Myeloid-derived suppressor cells (MDSCs), which exerts pivotal functions in immunosuppression, a key participator tumor microenvironment and novel target for therapy. Here curcumin (Cur) was employed as specific MDSCs repressor to inhibit number function MDSCs. Moreover, self-assembled nano-filament system generated through conjugation Cur peptide. In vivo study demonstrated powerful...
Abstract Radiation is an essential preparative procedure for bone marrow (BM) transplantation and cancer treatment. The therapeutic efficacy of radiation associated toxicity varies from patient to patient, making it difficult prescribe optimal patient‐specific irradiation dose. molecular determinants response remain unclear. AIM2‐like receptors (ALRs) are key players in innate immunity determine the course infections, inflammatory diseases, senescence, cancer. Here reported that mice lacking...
Interleukin-10 (IL-10) initiates potent anti-inflammatory effects via activating its cell surface receptor, composed of IL-10R1 and IL-10R2 subunits. The level is a major determinant the cells' responsiveness to IL-10. Here, series biochemical analyses using 293T cells reconstituted with IL-10R1, we identify latter as novel substrate βTrCP-containing ubiquitin E3 ligase. Within intracellular tail canonical (318DpSGFGpS) slightly deviated (369DpSGICLQEP) βTrCP recognition motif can additively...
Summary Bone fracture healing is a multistage regenerative process that requires the collaboration of various cell types, with approximately 5%‐10% fractures not properly. Accumulating evidence suggests dysregulations in immune system are associated defective healing. In cohort 30 bone patients between 50 and 62 years age, 8 displayed delayed Compared to 22 normal patients, these presented significantly lower frequencies CD 4 + 25 hi Foxp3 canonical regulatory T cells immediately following...
Abstract There is a growing body of evidence suggesting that Hashimoto’s thyroiditis (HT) may contribute to an increased risk papillary thyroid carcinoma (PTC). However, the exact relationship between HT and PTC still not fully understood. The objective this study was identify potential common biomarkers be associated with both HT. Three microarray datasets from GEO database RNA-seq dataset TCGA were collected shared differentially expressed genes (DEGs) PTC. A total 101 identified as DEGs,...
Nowadays, the main reason for failure of large-scale systems developments is that requirements analysis stage cannot produce complete, understandable, unambiguous traceable and testable system documents. To conquer this problem, from point view "requirements engineering" (RE), formalization RE process discussed three aspects: a full model, formal representation verification. taken as growing in 3D space sociology, methodology technology, spiral lifecycle model given to illustrate its social...
Endothelial cells (ECs) form a critical barrier between blood and parenchymal play an important role in many pathologic conditions, including sepsis. ECs are highly adaptive to their microenvironment also act as responder microbial pathogens. Though thought display extensive heterogeneity, detailed profiling of the vivo EC gene expression program has been limited by challenges isolating from complex tissues phenotypic drift associated with manipulation expansion vitro . We applied system...
Osteoporosis is a skeletal disorder characterized by compromised bone strength predisposing person to an in-creased risk of fracture. The overall rate osteoporosis increasing annually around the world, especially among elderly people, resulting in heavier social-economic burden. Till now, certain anti-osteoporosis medications have been ap-plied prevent and/or treat mechanism either decreasing excessive resorption or promoting formation. However, efficacy those therapies varies sometimes...