A5100334008- RNA modifications and cancer
- Hepatitis C virus research
- Cancer-related gene regulation
- Pancreatic and Hepatic Oncology Research
- Hepatitis B Virus Studies
- Epigenetics and DNA Methylation
- Renal and related cancers
- Renal cell carcinoma treatment
- Liver Disease Diagnosis and Treatment
- Cancer-related molecular mechanisms research
- Chemical Synthesis and Analysis
- Hepatitis Viruses Studies and Epidemiology
- Supramolecular Self-Assembly in Materials
- Uterine Myomas and Treatments
- Gynecological conditions and treatments
- Liver Disease and Transplantation
- Cancer Genomics and Diagnostics
- Fibroblast Growth Factor Research
- Advanced biosensing and bioanalysis techniques
- Monoclonal and Polyclonal Antibodies Research
- Endometrial and Cervical Cancer Treatments
- Random lasers and scattering media
- Pediatric health and respiratory diseases
- Alkaline Phosphatase Research Studies
- Cervical Cancer and HPV Research
Chongqing Medical University
2022-2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2023-2024
Zhangzhou Normal University
2023
Lanzhou University of Technology
2023
Guangzhou Medical University
2014-2022
Capital Medical University
2013-2022
East China Jiaotong University
2022
National Clinical Research Center for Digestive Diseases
2019-2022
Beijing Friendship Hospital
2018-2022
First Affiliated Hospital Zhejiang University
2020
Hepatitis B surface antigen (HBsAg) clearance represents a clinical cure, although the rate is extremely low. The aim of this study was to evaluate feasibility and safety profiles pegylated‐interferon α‐2a (PEG‐IFNα‐2a) as therapeutic option for inactive HBsAg carriers. There were 144 carriers enrolled divided into group (102 subjects) control (42 subjects). PEG‐IFNα‐2a combined with adefovir dipivoxil used treatment subjects hepatitis virus DNA <20 IU/mL 20 ≤ < 2,000 IU/mL,...
Despite the knowledge of many genetic alterations present in osteosarcoma, complexity this disease precludes placing its biology into a simple conceptual framework. Cytotoxic T-lymphocyte antigen-4 (CTLA-4) plays important roles downregulating T-cell activation, thereby attenuating anti-tumor responses and increasing cancer susceptibility. Polymorphisms CTLA-4 gene are associated with different autoimmune diseases cancers. The current study evaluated association four mutations, −1661A/G...
Despite the knowledge of many genetic alterations present in osteosarcoma, complexity this disease precludes placing its biology into a simple conceptual framework. Lysyl oxidase (LOX) catalyzes cross-linking elastin and collagen, which is essential for structural integrity function bone tissue. In current study, we performed genomic sequencing on all seven exons -including intron-exon splice sites, putative promoter region LOX gene - followed by luciferase reporter assay to analyze newly...
Abstract Background Accurate preoperative assessment of the efficacy high-intensity focused ultrasound (HIFU) ablation for uterine fibroids is essential good treatment results. The aim this study was to develop robust radiomics models predicting prognosis HIFU-treated and explain internal predictive process model using Shapley additive explanations (SHAP). Methods This retrospective included 300 patients with who received HIFU were classified as having a favorable or unfavorable based on...
Abstract Purpose Uterine fibroid is the most common benign tumor in female reproductive organs. In order to guide treatment, it crucial detect location, shape, and size of tumor. This study proposed a deep learning approach based on attention mechanisms segment uterine fibroids automatically preoperative Magnetic Resonance (MR) images. Methods The method U‐Net architecture integrates two mechanisms: channel squeeze‐and‐excitation (SE) blocks with residual connections, spatial pyramid pooling...
Although Tim-3 & PD-L1 signaling pathways play important roles in negatively regulating immune responses, their chlamydial infection have not been evaluated.Neutralization antibodies targeting and were used to treat mice. Following an intravaginal with C. muridarum organisms, mice or without the dual antibody treatment compared for live organism shedding from lower genital tract inflammatory pathology upper tract.Mice treated anti-Tim-3 anti-PD-L1 displayed a time course of similar that...
Various viral kinetics among patients with acute hepatitis B (AHB) have been observed in clinical practice. This study investigated the virological, biochemical, and serological characteristics of AHB adults. A total 192 adult were recruited between December 2010 January 2014. The quantification biochemical serologic markers for virus (HBV) infection was monitored from onset. Of patients, 113 followed up. One patient died due to liver failure, 2 developed chronic HBV infection. Clinical...
To investigate the differences in HPV genotypes and clinical indicators between cervical squamous cell carcinoma adenocarcinoma to identify independent predictors for differentiating adenocarcinoma.A total of 319 patients with cancer, including 238 81 adenocarcinoma, were retrospectively analysed. The characteristics laboratory indicators, genotypes, SCCAg, CA125, CA19-9, CYFRA 21-1 parity, analysed by univariate multivariate analyses, a classification model was established. validated 96...
Phase imaging normally employs coherent a light source while an incoherent is not preferred due to its random wavefront. Another challenge for practical phase through scattering media, which scatter the photons in manner and lead seriously distorted images of speckles. Based on convolutional neural network (CNN), this paper presents approach media using source. A CNN was trained utilized reconstruct target from captured Similarities over 90% between reconstructed their have been achieved. It...
Liver cirrhosis is the end stage of chronic liver disease and as progresses to decompensated cirrhosis, mortality rate patients' increases significantly. The goal controlling etiology or treatment in improve function patients, stabilize condition reverse decompensation, reduce recurrence events rate. However, presently, there are few studies on reversal cirrhotic decompensation/ re-compensation. Moreover, effect prophylactic re-compensation, evaluation indicators duration structure hepatic...
YAP (gene symbol YAP1) as a potential oncoprotein, is positively correlated with the malignancy of various tumors.However, overexpression alone in multiple normal tissue cells has failed to induce tumor formation and underlying mechanism poorly understood.Herein, we show that activation directly induces transcription its negative regulator, SAV1, constitute feedback loop, which plays vital role maintaining lung epithelial cell homeostasis was dysregulated non-small cancer (NSCLC).Notably,...
To investigate the efficacy and safety of an extended course (96-week) combination treatment with peginterferon alfa-2a (Peg-IFNa-2a; 40 kd] plus adefovir (ADV) for treating chronic hepatitis B (CHB) in Chinese patients negativity e antigen (HBeAg).A total 25 consecutive HBeAg-negative CHB were administered Peg-IFNa-2a (135-180 mug/week) ADV (10 mg/day) 96 weeks. All followed-up 24 weeks after completion. Levels virus (HBV) DNA surface (HbsAg) measured by fluorescence quantitative polymerase...
Gel permeation chromatography (GPC) coupled with multi‐angle laser light scattering (MALLS) provides a tool to simultaneously measure the elution behavior and molecular shape of flexible polymers in their dependence on column flow rate solute concentration. As was increased, radius gyration (R g) first decreased little then increased gradually. In all cases, values R g, hydrodynamic h), ρ g/R h) as concentration increased. result, flow‐induced stretch concentration‐induced shrinking for gel...
To observe the clinical efficacy of combination therapy with peg-IFNalpha and adefovir (CPIA) in women who were hepatfis B virus (HBV) carriers had just given birth received telbivudine (LdT) during pregnancy for prevention mother-to-child transmission.One-hundred-and-fifty third trimester-pregnant HBV highly-viremic treated LdT until time birth. After delivery, those alanine aminotransferase (ALT) level exceeding two times upper limit normal DNA that decreased more than 31 gIU/mL or...
The care for patients with hepatocellular carcinoma (HCC) is challenging. This study to evaluate the effect of adjuvant transarterial chemoembolization (TACE) Barcelona Clinic Liver Cancer (BCLC) stage A HCC after hepatectomy.Consecutive BCLC A, treated by hepatectomy alone (HA) or TACE (HT), were retrospectively enrolled. Propensity score matching (PSM) was used balance baseline differences. recurrence-free survival (RFS) and overall (OS) evaluated using Kaplan-Meier. impact on outcome...
To investigate the effects of pegylated interferon a-2a (Peg-INFa-2a) treatment on expression CD8 and CD38 surface molecules lymphocytes from peripheral blood inactive hepatitis B antigen (HBsAg) carriers.Forty-four patients with virus (HBV) chronic infection (CHB) received a 48-week course Peg-INFa-2a treatment, 30 administered 135 mug/week 14 180 mug/week. Every 12 weeks subjects were assessed for HBsAg titer, presence anti-hepatitis e (HBe) antibody, serum alanine amino transaminase (ALT)...