A5026780957- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Autoimmune Bullous Skin Diseases
- Vasculitis and related conditions
- Systemic Lupus Erythematosus Research
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Urticaria and Related Conditions
- Ocular Oncology and Treatments
- Autoimmune and Inflammatory Disorders Research
- Ocular Infections and Treatments
- Melanoma and MAPK Pathways
- CNS Lymphoma Diagnosis and Treatment
- Cancer Immunotherapy and Biomarkers
- Bartonella species infections research
- Herpesvirus Infections and Treatments
- Lymphoma Diagnosis and Treatment
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Corneal Surgery and Treatments
- Leprosy Research and Treatment
- Drug-Induced Ocular Toxicity
- Sarcoidosis and Beryllium Toxicity Research
- Syphilis Diagnosis and Treatment
- Cytomegalovirus and herpesvirus research
Massachusetts Eye Research and Surgery Institute
2015-2024
Ocular Immunology and Uveitis Foundation
2015-2024
Mahidol University
2021
Siriraj Hospital
2021
University of Padua
2021
Unité de Nutrition Humaine
2021
March of Dimes
2021
Farabi Hospital
2016
Tehran University of Medical Sciences
2016
EyePoint Pharmaceuticals (United States)
2016
Drug-induced uveitis is a well-known effect of ocular inflammation that has been reported with many medications. Pembrolizumab newer generation the anti-programmed cell death-1 monoclonal antibodies was recently approved by Food and Drug Administration for treatment advanced melanoma. Immune-mediated adverse events involving different organs have in recent literature association this drug. We present first case pembrolizumab therapy.An 82-year-old man stage IV melanoma started on infusion...
Management of granulomatosis with polyangiitis (GPA)-associated peripheral ulcerative keratitis (PUK) is challenging and lacks definite guidelines. We aimed to summarize our treatment outcome experience patients GPA-PUK.The Massachusetts Eye Research Surgery Institution patient database was searched from 2005 2015 identify diagnosis PUK who suffered GPA. Individual histories were examined, strategies outcomes summarized.There 16 started a mean duration follow-up 64 months (range: 12-110 mo)....
To describe clinical manifestations, diagnostic approaches, therapy, and outcomes of biopsy-proven intraocular lymphoma.Review tertiary referral center records between 2005 2015.A total 51 eyes 26 patients were included; mean age onset was 60.42 years. Common ocular complaints included floaters (42%) blurred vision (35%); 62% had central nervous system involvement; 11% systemic lymphoma; 27% only involvement. Vitreous analysis positive for malignant cells in 77% on initial biopsy, 100%...
Purpose: To demonstrate the reliability of conjunctival biopsy analyzed by direct immunofluorescence (DIF) and supplemented with avidin-biotin complex immunoperoxidase (ABC) in diagnosing oMMP, report therapy response biopsy-positive patients, particularly when previously biopsy-negative elsewhere.Methods: Retrospective outcomes review 136 consecutive patients after for suspected oMMP.Results: Among 66% were diagnosed oMMP DIF 13% via supplemental ABC immunoperoxidase. Sensitivity increased...
Purpose To evaluate the wide-field fundus fluorescein angiography (WFA) characteristics of uveitis associated with juvenile idiopathic arthritis (JIA-uveitis).Methods Retrospective review records. WFA Spectralis (Heidelberg) JIA-uveitis patients were analyzed using scoring system by Angiography Scoring for Uveitis Nomenclature.Results Thirty-seven eyes 20 studied. A total score at least 1 was noted in 27 (72.97%). features included optic disc hyperfluorescence (51.35%), macular leakage...
Purpose: To evaluate whether long-term remission of ocular cicatricial pemphigoid (OCP) after withdrawal immunomodulatory therapy (IMT) is possible. Methods: A total 34 464 presenting patients (66 eyes) with biopsy-proven OCP in off IMT were identified finishing a 2-year regimen without active disease (2005-2015). Long-term for was defined as withdrawn from ≥1 year lacking clinically detectable progressive scarring according to Foster staging and subjective assessment. Results: All achieved...
Herein, we report a case of XEN gel stent implantation in patient with ocular cicatricial pemphigoid that successfully reduced glaucoma topical medication at one year.A 76-year-old male presented severe and advanced who required several medications to control intraocular pressure. Despite successful reduction inflammation immunomodulatory therapy, his regimen prevented total remission inflammation. One year after implantation, pressures were controlled without any medication, he had no off...
Purpose: To assess the long-term efficacy and safety of IVIg monotherapy in patients with recalcitrant ocular cicatricial pemphigoid (OCP).Methods: A chart review all OCP seen at Massachusetts Eye Research Surgery Institution (MERSI) between 2005 2015 was completed. Stage graded by using Foster grading system. infusion 2g/kg/cycle administered 3 consecutive days monthly.Results: Of 512 patients, 17 (34 eyes) treated were identified. Seven female ten male. The average age diagnosis...
Abstract Purpose Diagnosis and management of non‐infectious uveitis (NIU), a major cause blindness worldwide, are challenging. Corticosteroids, the cornerstone therapy, not appropriate for long‐term use, while non‐biologic biologic immunomodulators may be used some patients, data on their efficacy safety in this population limited. Repository corticotropin injection (RCI), believed to affect by multiple mechanisms, has received regulatory approval treatment ophthalmic diseases including...
Purpose: To report a case of uveitis and papillitis in patient with cryopyrin-associated periodic syndrome. Methods: Case report. A 44-year-old white woman long history inflammatory arthritis, diffuse erythematous rashes hives, hearing loss was referred to the Massachusetts Eye Research Surgery Institution for an evaluation chronic ocular inflammation. She diagnosed bilateral after comprehensive eye examination, which included dilated fundoscopy, optic nerve coherence tomography, fluorescein...
To show whether subcutaneous repository corticotropin injection (RCI, Acthar® Gel, a injection, can be an effective potential therapeutic agent for noninfectious retinal vasculitis.
To search findings that can explain the heterogeneity between Resistant and Responsive patients with birdshot chorioretinopathy.This was a retrospective observational case series on "Responsive" versus "Resistant" chorioretinopathy.One-hundred-eighty Ninety-nine were included in groups respectively. Multivariate analysis of paraclinical variables at first visit demonstrated mean deviation (p = .04), pattern standard < .001), optic nerve head leakage .012), large vessel staining .01), macular...
Purpose: To evaluate the efficacy of intravenous methotrexate and methylprednisolone in severe, sight-threatening ocular inflammatory conditions.Methods: This was a retrospective observational case series. Patients who had received for inflammation with at least 24 months follow-up were included study.Results: Ten patients (20 eyes) this study. Mean age 47.2 ± 17.7 (range:19-74). At 1-month visit, nine showed improvement one patient failed treatment. 12-month all remission. Two only on...