A5057811154- Ocular Diseases and Behçet’s Syndrome
- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Systemic Lupus Erythematosus Research
- Cytomegalovirus and herpesvirus research
- Cerebral Venous Sinus Thrombosis
- Ocular Oncology and Treatments
- Bartonella species infections research
- Ocular Infections and Treatments
- Drug-Induced Ocular Toxicity
- Ocular Surface and Contact Lens
- Glaucoma and retinal disorders
- Herpesvirus Infections and Treatments
- Sarcoidosis and Beryllium Toxicity Research
- Vasculitis and related conditions
- Inflammasome and immune disorders
- Syphilis Diagnosis and Treatment
- Dermatological and Skeletal Disorders
- Autoimmune Neurological Disorders and Treatments
- Rabies epidemiology and control
- Autoimmune and Inflammatory Disorders Research
- Renal Diseases and Glomerulopathies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Infectious Diseases and Tuberculosis
- Vector-borne infectious diseases
Istanbul University
2014-2023
Koç University
2017
Amerikan Hastanesi
2017
Massachusetts Eye Research and Surgery Institute
2016
Ocular Immunology and Uveitis Foundation
2016
Boston Sports & Shoulder Center
2016
Marmara University
2013
To report the outcomes of tocilizumab treatment for refractory ocular inflammatory diseases.A retrospective case series 17 patients (28 eyes) diagnosed with recalcitrant diseases including uveitis (10 cases), scleritis (six cases) and orbital pseudotumour (one case), who received between April 2010 March 2015. All were initiated 4 mg/kg or 8 tocilizumab. The primary outcome was absence inflammation achievement steroid sparing at 6 9 months. Secondary change in visual acuity major adverse...
Purpose: To develop an algorithm for the diagnosis of Behçet's disease (BD) uveitis based on ocular findings.Methods: Following initial survey among experts, we collected multi-center retrospective data 211 patients with BD and 207 other uveitides, identified findings a high diagnostic odds ratio (DOR). Subsequently, prospective 127 322 controls developed using Classification Regression Tree (CART) analysis expert opinion.Results: We 10 items DOR >5. The that provided highest accuracy in...
To quantitatively analyze in vivo morphology of subfoveal choroid during an acute attack Behçet uveitis.In this prospective study, 28 patients with uveitis ≤4-year duration, and control subjects underwent enhanced depth imaging optical coherence tomography. A novel custom software was used to calculate choroidal stroma-to-choroidal vessel lumen ratio. Subfoveal thickness measured at fovea 750 μm nasal, temporal, superior, inferior fovea. Patients fluorescein angiography indocyanine green...
To report the results of tocilizumab (TCZ) treatment in patients with Behçet uveitis (BU) who had failed conventional, interferon alpha, and anti-Tumor necrosis factor-alpha therapy.We reviewed records five BU treated monthly infusions TCZ 8 mg/kg. Outcome measures were visual acuity, anterior chamber cells, laser flare meter (LFM) readings, vitreous haze, central macular thickness (CMT), fluorescein angiography (FA) score.The clinical inactivity 20/50 or better vision achieved three female...
Purpose: The aims of this study were to evaluate the efficacy topical 0.05% cyclosporine A on clinical signs and symptoms vernal keratoconjunctivitis (VKC) examine its effect tear cytokine levels. Methods: Twenty-one patients with active VKC 15 healthy volunteers included. Patients treated A. Symptoms scored day enrollment at end month 1 3. Tear serum samples collected before third treatment. Interleukin (IL)-2, soluble IL-2 receptor (sIL-2R), IL-3, IL-4, IL-5, IL-6, IL-9, IL-13, IL-17,...
To describe clinical manifestations, diagnostic approaches, therapy, and outcomes of biopsy-proven intraocular lymphoma.Review tertiary referral center records between 2005 2015.A total 51 eyes 26 patients were included; mean age onset was 60.42 years. Common ocular complaints included floaters (42%) blurred vision (35%); 62% had central nervous system involvement; 11% systemic lymphoma; 27% only involvement. Vitreous analysis positive for malignant cells in 77% on initial biopsy, 100%...
Purpose: To screen for psychological disorders in patients with active uveitis.Methods: Patients were screened depression (BDI-II), state anxiety (STAI-I), VR-QOL (NEI-VFQ-25), and HR-QOL (SF-36). Association of sociodemographic clinical parameters analyzed. Multivariate linear regression models constructed NEI-VFQ-25 SF-36 subscales.Results: Of 99 patients, 37.3% positive 52.5% anxiety. Depressed had lower visual acuity the better seeing eye (p = 0.013) more frequently panuveitis 0.018)....
Amaç: Kedi tırmığı hastalığı oküler tutulumu olan hastaların klinik bulguları, tanı ve tedavi yaklaşımlarının değerlendirilmesidir
PURPOSE.To investigate the effect of interferon alfa-2a on T regulatory (Treg) cells, helper 17 (Th17) and expression Toll-like receptors (TLRs) in Behçet disease (BD) patients with uveitis.METHODS.Twenty-seven who received for active BD uveitis despite conventional immunomodulatory therapies healthy controls were enrolled.Peripheral blood Treg Th17 cell frequencies determined by flow cytometry as gated cells forrespectively.Th17 RAR-related orphan receptor (ROR)ct mRNA was verified...
To report a case series of six patients suffering from branch retinal artery occlusion due to Bartonella henselae infection, in order raise awareness this etiology the differential diagnosis occlusion.A retrospective with ocular cat scratch disease who presented at four tertiary medical centers Israel, Turkey and Saudi Arabia between years 2008-2014. Data retrieved records included demographic data, exposure, complaints, visual acuity, clinical findings imaging, laboratory assessment,...
Purpose: To describe fulminant toxoplasma retinochoroiditis induced by corticosteroid monotherapy.Methods: Clinical records of nine patients were reviewed.Results: All (five female, four male; aged 15–64 years) had been misdiagnosed as unilateral non-infectious uveitis and given systemic and/or local injections elsewhere. Mean disease duration before referral was 105.6 ± 71 (45–240) days. Visual acuity at presentation <20/200 in six eyes. Average lesion size 6.6 disc areas eight eyes all...
Purpose . To report the long-term results of corneal collagen cross-linking (CXL) with riboflavin and ultraviolet-A irradiation in 4 eyes 2 patients affected by pellucid marginal degeneration (PMD). Methods This study involved retrospective analysis PMD that underwent CXL treatment. Of eyes, three had only treatment one after an intrastromal ring segment implantation. We have pre- postoperatively evaluated uncorrected distance visual acuity (UDVA), best corrected (BCDVA), topography...
Purpose: To report the efficacy and safety of interferon (IFN) α-2a in patients with cystoid macular edema (CME) associated presumed ocular tuberculosis (TB). Methods: We reviewed clinical records 5 TB who had been treated IFN for recurrent CME during or after completion anti-tubercular therapy. was administered at an initial dose 3 million IU per day then tapered response. Treatment assessed by central thickness (CMT) measurement using spectral-domain optical coherence tomography visual...
Brucellosis may be associated with a wide range of ophthalmic manifestations including endophthalmitis, which is sight-threatening condition that needs to rapidly recognized and treated avoid permanent visual loss. A 26-year-old female 6-month history vision loss in the left eye was high dose systemic corticosteroids azathioprine an initial misdiagnosis elsewhere. dense vitreous haze opacities at posterior hyaloid area retinochoroiditis led diagnosis endogenous endophthalmitis presentation...
Bullous central serous chorioretinopathy (CSCR) is a rare variant of CSCR characterized by severe retinal detachment which especially involves the inferior quadrants. Corticosteroid therapy administered for systemic or ocular misdiagnoses may induce and exacerbate CSCR. The purpose this study was to report diagnosis treatment results an unusual case bullous induced periocular corticosteroid received at another medical center due misdiagnosis Vogt-Koyanagi-Harada disease.
Focal choroidal excavation is a pit that can be detected by optical coherence tomography. Central serous chorioretinopathy, neovascularization and polypoidal vasculopathy are pathologies associated with focal excavation. In this article, we present the follow-up treatment outcomes of three eyes two patients