A5079550958- Retinal and Optic Conditions
- Retinal Diseases and Treatments
- Ocular Diseases and Behçet’s Syndrome
- Retinal Imaging and Analysis
- Retinal Development and Disorders
- Liver Disease Diagnosis and Treatment
- Glaucoma and retinal disorders
- Systemic Lupus Erythematosus Research
- Diet, Metabolism, and Disease
- Liver Disease and Transplantation
- Cytomegalovirus and herpesvirus research
- Optical Coherence Tomography Applications
- Ophthalmology and Visual Impairment Studies
- Hepatitis C virus research
- Multiple Sclerosis Research Studies
- Nitric Oxide and Endothelin Effects
- Renal Diseases and Glomerulopathies
- Eicosanoids and Hypertension Pharmacology
- Photoacoustic and Ultrasonic Imaging
- Organ Transplantation Techniques and Outcomes
- Herpesvirus Infections and Treatments
- Neonatal and fetal brain pathology
- Chronic Myeloid Leukemia Treatments
- Chemotherapy-induced organ toxicity mitigation
- Optical Imaging and Spectroscopy Techniques
Minia University
2014-2024
University of Pecs
2023
The University of Texas Medical Branch at Galveston
2023
Imam Abdulrahman Bin Faisal University
2023
Mansoura University
2021-2023
University of Bonn
2022
Beni-Suef University
2022
Agricultural Genetic Engineering Research Institute
2021
Johns Hopkins Medicine
2010-2020
Johns Hopkins University
2010-2020
Optical coherence tomography studies in multiple sclerosis have primarily focused on evaluation of the retinal nerve fibre layer. The aetiology changes is thought to be secondary optic demyelination. objective this study was use optical determine if a subset patients with exhibit primary neuronopathy, absence retrograde degeneration layer and ascertain such may any distinguishing clinical characteristics. We identified 50 predominantly macular thinning (normal fibre-layer thickness average...
To assess eyes with neuromyelitis optica (NMO) for morphologic retinal abnormalities utilizing high-definition optical coherence tomography (OCT) imaging.In this cross-sectional study, 39 patients NMO spectrum disorders and age- sex-matched healthy controls underwent spectral-domain OCT visual function testing.Microcystic macular edema (MME) of the inner nuclear layer (INL) was identified in 10 (26%) exclusively found a history optic neuritis (ON). MME had lower high- low-contrast...
Abstract Background The purpose of this study is to describe and quantify the benefit ultra-wide-field imaging fluorescein angiography (FA) in management non-infectious retinal vasculitis. In prospective observational cohort series, patients with vasculitis were evaluated enrolled by four investigators from Divisions Retina Ocular Immunology at Wilmer Eye Institute. each patient, disease activity need for changes assessed, based on clinical examination or without standard (60°) then addition...
The purpose of this study is to evaluate the ocular tolerability and efficacy sirolimus administered as subconjunctival or intravitreal injections in patients with non-infectious uveitis. Sirolimus a Therapeutic Approach for Uveitis (SAVE) prospective, randomized, open-label, interventional study. Thirty were enrolled randomized 1:1 ratio receive either 352 μg 1,320 at days 0, 60, 120, primary endpoint month 6.At 6, all subjects active uveitis baseline showed reduction vitreous haze one more...
Punctate inner choroidopathy (PIC) is an ocular inflammatory disease. Spectral domain optical coherence tomography (SD-OCT) allows detailed visualization of retinal and choroidal structures. We aimed to describe the changes on SD-OCT associated with PIC lesions localized in macula.Retrospective case series: not neovascularization (CNV) captured by macular scans were identified characterized.Twenty-seven from seven patients (eight eyes) classified into four categories according disease...
Purpose: : To determine the efficacy and safety of repeated intravitreal subconjunctival administrations sirolimus in patients with noninfectious uveitis at 1 year Sirolimus as a Therapeutic Approach UVEitis (SAVE) Study. Methods: Open-label, prospective, randomized interventional clinical trial which 30 intermediate, posterior, or panuveitis were 1:1 to receive 352-μg 1320-μg subconjunctival. was administered days 0, 60, 120. At month 6, all subjects allowed intervals greater than equal 2...
We explored whether greater amounts of short-term variability in visual acuity (VA), contrast sensitivity (CS), or field (VF) retinitis pigmentosa (RP) was related to disease severity psychosocial factors.We obtained spectral domain-optical coherence tomography 27 RP subjects and determined (SD) VA, CS, VF during a mean 16 tests self-administered at home on personal computer twice week. Subjects completed the Positive Negative Affect Schedules each computer-test session, SF-36 general health...
Context: The anticancer drug methotrexate (MTX) may cause multi-organ toxicities, including nephrotoxicity.Objective: To investigate effects of peroxisome proliferator activator receptor (PPAR)-α and -γ agonists; fenofibrate (FEN) pioglitazone (PIO), in MTX-induced nephrotoxicity rats.Methods: Rats were given FEN or PIO (150 5 mg/kg/day, respectively) orally for 15 days. MTX was injected as a single dose 20 mg/kg, i.p. at day 11 experiment, with without either PPAR agonists.Results: induced...
Cilostazol and verapamil are widely used cardiovascular drugs, explored a beneficial effect on different organs-induced toxicities. We investigated whether the Nrf2 (nuclear erythroid factor 2) its downstream pathway involved in protective role of these drugs against TAA-induced renal damage. Renal biomarkers (creatinine urea) histopathology were observed. Antioxidant oxidant indicators; superoxide dismutase (SOD), reduced glutathione (GSH), malondialdehyde (MDA) total nitrite (NO) also...
To compare the frequencies of attacks before and after immunomodulatory therapy (IMT) with mycophenolate mofetil (MMF) in recurrent punctate inner choroidopathy (PIC) to report fundus autofluorescence (FAF) findings.Eight patients who had at least two episodes increased activity MMF 12 months documented clinical course were included. The compared. FAF images evaluated.Before MMF, 8 experienced 19 disease activity; during therapy, 3 (38%) 6 episodes. attack 1.09 ± 0.75 0.23 0.32 treatment (p...