A5039029185- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Corneal surgery and disorders
- Corneal Surgery and Treatments
- Glaucoma and retinal disorders
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Renal Diseases and Glomerulopathies
- Complement system in diseases
- Retinal Development and Disorders
- Ocular Surface and Contact Lens
- Ocular Infections and Treatments
- Salivary Gland Disorders and Functions
- Retinal and Macular Surgery
- Systemic Lupus Erythematosus Research
- Adenosine and Purinergic Signaling
- Retinal Imaging and Analysis
- HER2/EGFR in Cancer Research
- Visual perception and processing mechanisms
- Olfactory and Sensory Function Studies
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Dental Anxiety and Anesthesia Techniques
- Cytomegalovirus and herpesvirus research
- Surface Roughness and Optical Measurements
- Ophthalmology and Visual Impairment Studies
Smith-Kettlewell Eye Research Institute
2024
Stanford University
2024
Kodiak Sciences
2018-2020
Santen (United States)
2012-2014
Adamas Pharmaceuticals (United States)
2013
QLT (Canada)
2005
University Health Network
2000-2003
Toronto Western Hospital
2000-2003
University of Toronto
2000-2001
Toronto General Hospital
2000-2001
Purpose. To review the indications and patient characteristics for penetrating keratoplasty (PKP). Methods. Retrospective of records at Pathology Service, Department Ophthalmology, University Toronto from 1964 to 1997. Results. The 6,222 were reviewed. leading PKP regraft, keratoconus (KC), pseudophakic bullous keratopathy (PBK), Fuchs' dystrophy, viral infections, trauma, in that order. During second half 1980s, PBK replaced KC as indication transplantation. average age patients increased...
<h3>Objective</h3> To compare the treatment effect and safety of photodynamic therapy with verteporfin using a standard (SF) or reduced (RF) light fluence rate that placebo in patients subfoveal minimally classic choroidal neovascularization (CNV) age-related macular degeneration. <h3>Design</h3> Phase 2, multicenter, double-masked, placebo-controlled, randomized clinical trial. <h3>Setting</h3> Nineteen ophthalmology practices North America Europe. <h3>Participants</h3> Patients initial...
The purpose of this study is to evaluate the ocular tolerability and efficacy sirolimus administered as subconjunctival or intravitreal injections in patients with non-infectious uveitis. Sirolimus a Therapeutic Approach for Uveitis (SAVE) prospective, randomized, open-label, interventional study. Thirty were enrolled randomized 1:1 ratio receive either 352 μg 1,320 at days 0, 60, 120, primary endpoint month 6.At 6, all subjects active uveitis baseline showed reduction vitreous haze one more...
Purpose. To compare repeat penetrating keratoplasty (PKP) with primary PKP respect to patient characteristics, survival rates, and risk factors for graft failure. Methods. Retrospective, consecutive, noncomparative case series of 116 patients who underwent were identified from a cohort 696 PKPs performed by one surgeon over 7.5-year period. Results. Compared PKP, regraft 5 years older, had higher rate peripheral anterior synechiae (PAS), more likely require intraocular pressure...
Purpose. To determine overall 2-and 5-year corneal graft survival rates and to identify risk factors for failure in our patient population. Methods. A retrospective chart review of 696 patients undergoing transplantation performed by a single surgeon at The Toronto Western Hospital over 7.5-year period. Results. total 468 eyes met the inclusion criteria this study. Overall, were 78.8% 64.5%, respectively. In univariate analysis, age, gender, history glaucoma, preoperative diagnosis, type...
To assess corneal endothelial toxicity of diluted povidone-iodine (PI) in vivo and vitro.Cell Biology Laboratory the for Intraocular Microsurgery Implants, Goldschleger Eye Research Institute, Sackler School Medicine, Tel-Aviv University, Chaim Sheba Medical Center, Tel-Hashomer, Israel.In an vitro study, cultured bovine cells were exposed to PI. The degree cell damage was determined by staining with trypan blue comparing results those a control group. In single dose PI injected into...
Purpose: To evaluate the pharmacokinetics (PK) and tolerability of a proprietary sirolimus depot-forming ocular formulation in rabbits humans after single intravitreal (IVT) injection. Methods: New Zealand White (NZW) were intravitreally injected both eyes with an injectable 5 (3 PK 2 tolerability) studies. The received up to approximately 220 μg per eye. At desired timing post-injection, animals euthanized; enucleated, frozen, dissected separate sclera, retina/choroid, vitreous humor (VH)....
<h3>Objective</h3> To determine whether the clinical outcome of corneal transplantation performed with tissue stored in Chen Medium (CM; Laboratories, Phoenix, Md) is superior to that Optisol-GS (Chiron Ophthalmics, Irvine, Calif). <h3>Design</h3> Randomized, double-masked trial. <h3>Participants and Setting</h3> Ninety patients undergoing at a tertiary center. <h3>Intervention</h3> Donor cornea pairs were stored, one CM other Optisol-GS, transplanted, followed up for 3 months. <h3>Main...
Purpose. There have been no reported cases of hepatitis C virus (HCV) transmission by corneal transplantation. Previous studies also shown correlation between HCV seropositivity and the presence RNA in tissues. This study aims to investigate such provide further evidence possible transmissibility via grafts. Methods. Of 1,619 potential donors Eye Bank Canada over a 1-year period, 15 tested HCV-positive second-generation Abbott enzyme immunoassay (EIA) 2.0 assay. Their sera were with...
Purpose. To compare corneal endothelial cell function by measuring thickness during temperature reversal between corneas stored in two different storage media, Optisol GS and Chen Medium (CM). Methods. Twenty paired from 10 human donors were randomly assigned for at 4°C (10 corneas) or CM corneas). The media masked, measurements done a masked fashion. After 48 hours, was measured ultrasonic pachymetry 2-hour intervals 12 which time the perfused with BSS (balanced salt solution) Plus 37°C....
Purpose The purpose of this study is to evaluate the safety and efficacy intravitreal injections DE-109 ophthalmic suspension. Results Primary Outcome Measures: Proportion subjects with vitreous haze score [Time Frame: 5 months] [Designated as issue: Yes] Conclusion Study Design: Allocation: Randomized Endpoint Classification: Safety/Efficacy Intervention Model: Parallel Assignment Masking: Double Blind (Subject, Caregiver, Investigator, Outcomes Assessor) Purpose: Treatment