A5000683013- Glaucoma and retinal disorders
- Retinal Imaging and Analysis
- Retinal Diseases and Treatments
- Corneal surgery and disorders
- Intraocular Surgery and Lenses
- Intensive Care Unit Cognitive Disorders
- Biomedical Text Mining and Ontologies
- Ophthalmology and Visual Impairment Studies
- Machine Learning in Healthcare
- Electronic Health Records Systems
- Ophthalmology and Visual Health Research
- Acute Ischemic Stroke Management
- Retinal and Optic Conditions
- Ocular Diseases and Behçet’s Syndrome
- Artificial Intelligence in Healthcare and Education
- Diversity and Career in Medicine
- Retinopathy of Prematurity Studies
- Dementia and Cognitive Impairment Research
- Anesthesia and Sedative Agents
- Cerebral Venous Sinus Thrombosis
- Neurological Disorders and Treatments
- Ocular Infections and Treatments
- Digital Imaging in Medicine
- Nerve injury and regeneration
- Ophthalmology and Eye Disorders
Stanford University
2005-2025
Indiana University School of Medicine
2017-2025
Smith-Kettlewell Eye Research Institute
2018-2025
Indiana University
2025
University School
2025
University of Michigan
2014-2024
Outcomes Research Consortium
2024
Indiana University – Purdue University Indianapolis
2015-2024
Palo Alto Institute
2024
Oregon Health & Science University
2024
Large language models (LLMs) like ChatGPT appear capable of performing a variety tasks, including answering patient eye care questions, but have not yet been evaluated in direct comparison with ophthalmologists. It remains unclear whether LLM-generated advice is accurate, appropriate, and safe for patients.To evaluate the quality ophthalmology generated by an LLM chatbot ophthalmologist-written advice.This cross-sectional study used deidentified data from online medical forum, which...
ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXT[123I]-2.beta.-carbomethoxy-3.beta.-(4-iodophenyl)tropane: high-affinity SPECT (single photon emission computed tomography) radiotracer of monoamine reuptake sites in brainJohn L. Neumeyer, Shaoyin Wang, Richard A. Milius, Ronald M. Baldwin, Yolanda Zea-Ponce, Paul B. Hoffer, Elzbieta Sybirska, Mohammed Al-Tikriti, Dennis S. Charney, and Cite this: J. Med. Chem. 1991, 34, 10, 3144–3146Publication Date (Print):October 1, 1991Publication History...
Background and Purpose— The concept of the neurovascular unit suggests that effects on brain vasculature must be considered if neuroprotection is to achieved in stroke. We previously reported 12/15-lipoxygenase (12/15-LOX) upregulated peri-infarct area after middle cerebral artery occlusion mice, 12/15-LOX contributes damage ischemia–reperfusion. current study was designed investigate involvement vascular injury ischemic brain. Methods— In cell culture, a human microvascular endothelial line...
To investigate the association between myopia and prevalence of glaucoma.
Advances in artificial intelligence have produced a few predictive models glaucoma, including logistic regression model predicting glaucoma progression to surgery. However, uncertainty exists regarding how integrate the wealth of information free-text clinical notes. The purpose this study was predict requiring surgery using deep learning (DL) approaches on data from electronic health records (EHRs), features structured and natural language processing notes.Development DL an observational...
Purpose.: To identify risk factors for inadequately corrected refractive error in the United States. Methods.: This cross-sectional study included 12,758 participants 12 years of age and older from 2005 to 2008 National Health Nutrition Examination Survey. The primary outcome was proportion individuals with inadequate correction whom would result a visual acuity 20/40 or better. predictor race/ethnicity. Secondary predictors age, sex, annual household income, education, insurance, type...
Delirium in the intensive care units (ICUs) is prevalent, with both delirium duration and severity associated adverse outcomes. We designed a pragmatic trial to test efficacy of pharmacological management (PMD) bundle improving delirium/coma-free days reducing among ICU patients.A randomized clinical trial.Medical, surgical, progressive ICUs three tertiary hospitals.A total 351 critically ill multicomponent PMD consisting exposure 20 definite anticholinergic medications benzodiazepines...
Purpose: We evaluated the use of massive transformer-based language models to predict glaucoma progression requiring surgery using ophthalmology clinical notes from electronic health records (EHRs). Methods: Ophthalmology for 4512 patients at a single center 2008 2020 were identified EHRs. Four different pre-trained Bidirectional Encoder Representations Transformers (BERT)-based fine-tuned on patients' first 120 days follow-up task predicting which would require surgery. Models with standard...
Regular screening for diabetic retinopathy often is crucial the health of patients with diabetes. However, many factors may be barriers to regular and associated disparities in rates.
To investigate the relationship between central corneal thickness (CCT) and demographics, determine whether CCT may be a substantial mediator of relationships glaucoma its demographic risk factors.This cross-sectional study included patients in Kaiser Permanente Northern California health plan from January 1, 2007 to December 31, 2011 who were 40 years older had documented measurement (N=81,082). Those with any cornea-related diagnoses or history refractive surgery excluded. Demographic...
Introduction:Diabetic retinopathy (DR) is the leading cause of new-onset blindness in adults. Telemedicine a validated, cost-effective method to improve monitoring. However, little known patients' attitudes toward telemedicine for DR. Our study explores factors that influence participating telemedicine.Materials and Methods:Ninety seven participants university Veterans Administration setting completed survey. Only people with diabetes mellitus (DM) were included. The main outcome was...
<h3>Importance</h3> Ophthalmic screening to check for diabetic retinopathy (DR) is important prevent vision loss in persons with diabetes. The American Academy of Ophthalmology recommends that ophthalmic DR occur beginning at 5 years after initial diabetes diagnosis youths type 1 diabetes; the Diabetes Association 2 time diagnosis. To our knowledge, it unknown what extent obtain eye examinations accordance these guidelines. <h3>Objective</h3> assess rate obtaining and factors associated...
The purpose of this study was to develop a model predict whether or not glaucoma will progress the point requiring surgery within following year, using data from electronic health records (EHRs), including both structured and free-text notes.A cohort adult patients identified EHR at Stanford University between 2008 2020, with clinical notes, demographics, diagnosis codes, prior surgeries, information, intraocular pressure, visual acuity, central corneal thickness. Words patients' notes were...
Flow cytometry is a vital diagnostic tool for hematologic and immunologic disorders, but manual analysis prone to variation time-consuming. Over the last decade, artificial intelligence (AI) has advanced significantly. In this study, we developed validated an AI-assisted flow workflow using 379 clinical cases from 2021, employing 3-tube, 10-color panel with 21 antibodies primary immunodeficiency diseases related immunological disorders. The AI software (DeepFlow™, version 2.1.1) fully...
Brain size and cellular heterogeneity are tightly regulated by species-specific proliferation differentiation of multipotent neural progenitor cells (NPCs). Errors in this process among the mechanisms primary hereditary microcephaly (MCPH), a group disorders characterized reduced brain intellectual disability. Biallelic CIT missense variants that disrupt kinase function (CITKI/KI) frameshift loss-of-function (CITFS/FS) genetic basis for MCPH17; however, catalytic activity development NPC...
Hemorrhagic conversion after tissue plasminogen activator (tPA) stroke therapy has been linked with elevations in matrix metalloproteinase-9 (MMP-9) at the neurovascular interface. Here, we test idea that statins may directly ameliorate tPA-induced MMP-9 dysregulation.Recombinant human tPA (5 microg/mL) was added to primary rat cortical astrocytes. Zymography used quantify levels conditioned media. Effects of simvastatin or Rho kinase inhibitor Y-27632 were assessed by pretreating cells...