A5035936368- 3D Printing in Biomedical Research
- RNA modifications and cancer
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Epigenetics and DNA Methylation
- Growth Hormone and Insulin-like Growth Factors
- Cell Image Analysis Techniques
- Microtubule and mitosis dynamics
- Thyroid Cancer Diagnosis and Treatment
- Ion channel regulation and function
- Cancer Cells and Metastasis
- Renal and related cancers
- Neuroscience and Neuropharmacology Research
- Ion Channels and Receptors
Weizmann Institute of Science
2017-2024
Meir Medical Center
2017
Brain size and cellular heterogeneity are tightly regulated by species-specific proliferation differentiation of multipotent neural progenitor cells (NPCs). Errors in this process among the mechanisms primary hereditary microcephaly (MCPH), a group disorders characterized reduced brain intellectual disability. Biallelic CIT missense variants that disrupt kinase function (CITKI/KI) frameshift loss-of-function (CITFS/FS) genetic basis for MCPH17; however, catalytic activity development NPC...
Abstract PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural cells. has been suggested to contribute 1p36 deletion syndrome, one the most prevalent subtelomeric microdeletion syndromes. We report patient with de novo nonsense mutation in coding sequence, accompanied by lissencephaly microcephaly features. Human cells were genetically modified mimic this mutation, generating cortical organoids that...
Abstract Brain organoids are an emerging technique for studying human neurodevelopment in vitro, with biomedical implications. However, three‐dimensional tissue culture poses several challenges, including lack of nutrient exchange at the organoid core and limited imaging accessibility whole organoids. Here we present a method culturing micro‐fabricated device that enables situ real‐time over weeks efficient by diffusion. Our on‐chip approach offers means dynamics development, cell...
PRDM16 is a dynamic transcriptional regulator of various stem cell niches, including adipocytic, hematopoietic, cardiac progenitors, and neural cells. has been suggested to contribute 1p36 deletion syndrome, one the most prevalent subtelomeric microdeletion syndromes. We report patient with de novo nonsense mutation in coding sequence, accompanied by lissencephaly microcephaly features. Human cells were genetically modified mimic this mutation, generating cortical organoids that exhibited...