Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and mechanisms involved. Two doses (10 100 mg/kg) CoQ10 were administered orally to rats 8 days, in presence or absence induced by a single intraperitoneal injection Dox (15 at day 4 experiment. Our results showed that low dose succeeded reversing control levels (e.g., blood urea...

Nephrotoxicity is one of the limiting factors for using doxorubicin (DOX). Interleukin 1 has major role in DOX-induced nephrotoxicity, so we investigated effect interleukin receptor antagonist diacerein (DIA) on nephrotoxicity. DIA (25 and 50 mg/kg/day) was administered orally to rats 15 days, presence or absence nephrotoxicity induced by a single intraperitoneal injection DOX (15 mg/kg) at 11th day. We measured levels serum urea, creatinine, renal reduced glutathione (GSH), malondialdehyde...

Doxorubicin (DOX) is a widely used antineoplastic drug whose efficacy limited by its cardiotoxicity. The aim of this study was to investigate the possible protective role antidiabetic drugs metformin (250 mg/kg dissolved in DW p.o. for seven days) and sitagliptin (10 model DOX-induced (single dose 15 i.p. at fifth day) cardiotoxicity rats. Results our revealed that pretreatment with or produced significant (P < 0.05) cardiac protection manifested decrease serum levels LDH CK-MB enzymes MDA...

Background/Aims: SGLT-2 inhibitors have been shown to be nephroprotective in diabetes.Here, we examined if one of these drugs (canagliflozin) could also ameliorate non-diabetic chronic kidney disease (CKD).Methods: CKD was induced rats by feeding them adenine (0.25% w/w for 35 days) and canagliflozin (10 or 25 mg/kg, gavage) given with without adenine.Several conventional novel plasma urine biomarkers tissues morphology were used investigate the effect on structure function.Results: Rats fed...

Sodium-glucose cotransporter 2 inhibitors (SGLT2i) are currently available for the management of type diabetes mellitus. SGLT2i acts by inhibiting renal SGLT2, thereby increasing glucosuria and lowering serum glucose. Recent trials emerging supporting a role irrespective diabetic status pointing towards that have other mechanisms actions beyond blood sugar control. In this review, we will shed light on group medications act as in non-diabetics focusing pre-clinical clinical data highlighting...

Riociguat is a soluble guanylate cyclase (sGC) activator that increases the levels of cyclic guanosine monophosphate (cGMP). cGMP known to play key role in regulating kidney function. This research sought investigate possible protective effects riociguat on kidneys context chronic disease (CKD). CKD was induced male Wistar rats through adenine administration. A total 24 were allocated into four groups and administered treatments over period 35 days. Group 1 received normal diet vehicle...

SUMMARY 1. The in vivo inhibition of angiotensin II (AII) receptor binding the rat brain, kidney and adrenal was investigated after intravenous administration AT 1 ‐selective AII antagonist losartan. 2. Male Sprague‐Dawley rats were administered intravenously either vehicle, or losartan at doses 1, 3 10 mg/kg. Plasma samples collected tissues removed 1,2, 8 24 h antagonist, effects on assessed by quantitative vitro autoradiography. 3. Losartan significantly increased plasma renin activity...

Context: The anticancer drug methotrexate (MTX) may cause multi-organ toxicities, including nephrotoxicity.Objective: To investigate effects of peroxisome proliferator activator receptor (PPAR)-α and -γ agonists; fenofibrate (FEN) pioglitazone (PIO), in MTX-induced nephrotoxicity rats.Methods: Rats were given FEN or PIO (150 5 mg/kg/day, respectively) orally for 15 days. MTX was injected as a single dose 20 mg/kg, i.p. at day 11 experiment, with without either PPAR agonists.Results: induced...

Methotrexate (MTX) is a commonly used antineoplastic and anti-rheumatoid drug whose efficacy limited by its hepatotoxicity. The aim of this study was to investigate the possible protective role captopril (100 mg/kg/day, p.o. for seven days), an angiotensin converting enzyme inhibitor, telmisartan (10 mg/kg/day II receptor blocker with peroxisome proliferative gamma (PPARγ) agonism, in model MTX (single dose 20 mg/kg i.p. at fifth day) induced hepatotoxicity rats. Results present revealed...

Cisplatin (CP) is a potent anticancer drug used to treat solid tumors. Its use, however, dose-limited by its nephrotoxicity. We aimed compare the effect of melatonin and curcumin given singly, with that combination these two agents on CP-induced nephrotoxicity in rats. CP (6 mg/kg, once intraperitoneally) induced as evidenced several significant adverse physiological, biochemical histopathological actions included reduction body weight, increased urine production, alterations some...

Abstract This work investigated the effect of N ‐acetylcysteine (NAC), on renal hemodynamics in cisplatin (CP)‐induced nephrotoxicity Wistar–Kyoto (WKY) rats. The animals were divided into four groups ( n = 5 or 6). first and second received normal saline (control) intraperitoneal (i.p.) (500 mg kg −1 per day for 9 days), respectively. third fourth given a single injection CP (5 ) an i.p. together with NAC At end experiment, rats anesthetized blood pressure flow monitored, followed by...

Sildenafil, the first drug for erectile dysfunction, has cardiopulmonary protective actions. A recent study reported that sildenafil given intraperitoneally (i.p.) attenuated cisplatin (CP)-induced nephrotoxicity. Here, we evaluated whether sildenafil, by two different routes and at doses, can attenuate CP-induced nephrotoxicity would also affect renal haemodynamics in CP-treated rats. Six groups of rats were treated with saline (controls), CP [5 mg/kg, once], (0.4 mg/kg/day, i.p. 5 days),...

We assessed the effect of treatment with dipeptidyl peptidase-4 inhibitor, sitagliptin, on adenine-induced chronic kidney disease (CKD). Six equal groups rats were given either normal food or mixed adenine (0.25% w/w for five weeks) to induce CKD. Some these also simultaneously treated sitagliptin (2.5 and 10 mg/kg/day, by gavage). Rats showed elevation blood pressure, decreased body weight increased relative weight. Adenine significantly plasma urea, creatinine, cystatin C, liver-type fatty...

We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second received normal saline (control) intraperitoneal (i.p.) (6 mg/kg) day 7, respectively. third fourth a single injection Cis 7 (1 mg/kg/day, orally) or vehicle for 10 days, At 11, animals anaesthetized blood collected kidneys removed. Another treated same as previous to measure renal flow. induced nephrotoxicity evidenced by biochemical,...

Cardiovascular diseases are responsible for a significant proportion of mortalities worldwide. Elderly patients the most affected by cardiovascular diseases, and because factors such as polypharmacy, multimorbidity, age-related changes in drug availability metabolism, they highly susceptible to occurrence drug–drug interactions. Drug–drug interactions among many drug-related problems leading negative outcomes inpatients outpatients. Thus, it is important investigate prevalence, involved...

The aim of this study was to investigate whether the hypotensive effect rat α‐calcitonin gene‐related peptide (αCGRP) in conscious rats is mediated by endothelium‐derived nitric oxide (NO) or opening adenosine 5′‐triphosphate (ATP)‐sensitive potassium (K ATP ) channels. Dose‐mean arterial pressure (MAP)‐response curves αCGRP were examined presence vehicle, phenylephrine, K channel antagonist glibenclamide NO synthase inhibitors, N G ‐nitro‐ l ‐arginine methyl ester ( ‐NAME) and d ‐NAME)....