A5032562386- Sarcoma Diagnosis and Treatment
- Bone Tumor Diagnosis and Treatments
- Genetic factors in colorectal cancer
- Oral and Maxillofacial Pathology
- Colorectal Cancer Screening and Detection
- Surgical Sutures and Adhesives
- Gastric Cancer Management and Outcomes
- Intestinal and Peritoneal Adhesions
- Electrospun Nanofibers in Biomedical Applications
- Cancer-related Molecular Pathways
- Chemotherapy-induced organ toxicity mitigation
- Cancer Immunotherapy and Biomarkers
- Prostate Cancer Treatment and Research
- Smoking Behavior and Cessation
- Histiocytic Disorders and Treatments
- Eosinophilic Disorders and Syndromes
- Colorectal and Anal Carcinomas
- Liver Disease Diagnosis and Treatment
- MicroRNA in disease regulation
- Pharmacological Effects and Toxicity Studies
- Cancer, Lipids, and Metabolism
- Hepatitis C virus research
- Wound Healing and Treatments
- RNA modifications and cancer
- Inflammasome and immune disorders
Sultan Qaboos University
2014-2025
Mansoura University
2012-2025
Sultan Qaboos University Hospital
2016-2025
Oman Medical College
2023
Oman Dental College
2023
Al-Azhar University
2018
Nutrition Sciences (Belgium)
2015
Muscat College
2014
University College London
2009-2010
CRUK Lung Cancer Centre of Excellence
2009-2010
A variety of analyses, including fluorescence in situ hybridization (FISH), quantitative PCR (qPCR) and array CGH (aCGH), have been performed on a series chordomas from 181 patients. Twelve (7%) tumours displayed amplification the T locus an additional two cases showed focal amplification; 70/181 (39%) were polysomic for chromosome 6, 8/181 (4.5%) primary minor allelic gain as assessed by FISH. No germline alteration was identified non-neoplastic tissue 40 Copy number seen similar percentage...
Chordomas are radio- and chemo-resistant tumours metastasise in as many 40% of patients. The aim this study was to identify potential molecular targets for the treatment chordoma. In view reported association chordoma tuberous sclerosis complex syndrome, available therapeutic agents against molecules PI3K/AKT/TSC1/TSC2/mTOR pathway, a tissue microarray 50 cases analysed expression active involved signalling pathway by immunohistochemistry selected number western blot analysis. were positive...
Abstract Chordoma, the molecular hallmark of which is T (brachyury), a rare malignant bone tumour with high risk local recurrence and from metastatic disease common late event. Currently, there no effective drug therapy for treating chordomas, although evidence that some patients respond to empirical use epidermal growth factor receptor (EGFR) antagonists. The aim this study was determine role EGFR in pathogenesis chordoma. Paraffin‐embedded material 173 chordomas 160 [sacro‐coccygeal ( n =...
Several recent studies have indicated the possible association between exposure to particulate air pollution and increased rate of morbidity mortality in patients with kidney diseases. The link this observation vascular damage has not been adequately addressed. Therefore, study aims investigate that might be associated diesel exhaust particles (DP) adenine (AD)-induced chronic disease (CKD) rats, ameliorative effect gum acacia (GA). CKD was induced by feeding AD (0.75%, w/w), DP (0.5 mg/kg)...
To the Editors: Kindler syndrome (KS) is a rare genetic disorder resulting from mutations in FERMT1 gene that causes abnormalities kindlin-1 protein. This leads to skin and mucous membrane fragility, increased sensitivity light gastrointestinal symptoms such as colitis, which resembles inflammatory bowel disease (IBD).1–3 Cytomegalovirus (CMV) colitis cause of newborns, most often observed individuals with weakened immune systems, although it can also occur healthy infants without...
Particulate air pollution (PAP) exposure is associated with increased morbidity and mortality, particularly in patients renal disease. However, there are only a few studies on the interaction between PAP injury, none agents that may ameliorate it. We studied cisplatin (CP) nephrotoxicity single to diesel exhaust particle (DEP) rats 24 h before sacrifice, assessed effect of co-treatment active ingredient Nigella Sativa seed oil, thymoquinone (TQ) thereon. Rats were injected intraperitoneally...
There is a global increase in the popularity of water-pipe tobacco smoking including Europe and North America. Nevertheless, little known about male reproductive effects smoke (WPS), especially after long-term exposure. Here we assessed WPS exposure (30 min/ day) mice for 6 months. Control were exposed to air-only same period time. Twenty-four h last exposure, testicular histopathology markers inflammation oxidative stress, tyrosine - protein kinase vascular endothelial growth factor...
We investigated the effect of levosimendan on cisplatin (Cis)-induced nephrotoxicity. Rats were divided into four groups (n = 6). The first and second received normal saline (control) intraperitoneal (i.p.) (6 mg/kg) day 7, respectively. third fourth a single injection Cis 7 (1 mg/kg/day, orally) or vehicle for 10 days, At 11, animals anaesthetized blood collected kidneys removed. Another treated same as previous to measure renal flow. induced nephrotoxicity evidenced by biochemical,...
Cytogenetic analysis has detected an accumulation of genetic lesions in oral cancers. Numerical changes chromosome 17 might be associated with up-regulation p53 gene, and could contribute to critical events carcinogenesis. The aim this study was reveal possible correlations between the numerical aberrations 17, deletion or amplification P53 gene histological grading patients squamous cell carcinoma (OSCC).
Triple-negative breast cancer (TNBC) is an aggressive type of in which calpain system plays important role its cellular processes including apoptosis and proliferation. Although such roles have been assessed tumor pathogenesis, the correlation expression to proliferating/apoptotic index has not studied yet. Immunohistochemical staining calpain-1 was performed on paraffin-embedded tissues correlate with clinicopathological variables outcome. The proliferation activity determined by...
Abstract Postoperative adhesion can cause complications, such as pain and organ blockage, in the abdominal regions. To address this issue, surgical techniques antiadhesive treatments are applied. Given significant role of vascularization band formation, Avastin (Ava) that targets vascular endothelial growth factor (VEGF) be applied to prevent peritoneal bands. Moreover, Alginate (Alg), a natural polysaccharide, is promising physical barrier Incorporating Ava into Alg hydrogel form 3D‐printed...
The alterations of EGFR and HER2/neu as growth factor receptors the cytoplasmic signal transduction proteins RAS/RAF/MAP kinases including its end effector molecule (ERK) are important in carcinogenesis many tumors. activation these protooncogenes prostate cancer is still under investigation. aim this work was to study EGFR, HER2- neu, inactive (non-phosphorylated) active (phosphorylated) ERK expression prostatic adenocarcinomas correlation clinical pathological parameters.
Abstract Background Primary carcinoma of the ovary (OCs) are responsible for a significant number deaths related to cancer, and have highest rate death cancers female reproductive organs. Programmed cell 1 (PD1) protein, acts as an immune checkpoint, has important role in down-regulation system by preventing activation T-cells, which will weaken autoimmunity increases self-tolerance. This study aimed at evaluation immunohistochemical (IHC) expression PD-L1 various primary surface ovarian...
Water-pipe smoking (WPS) is popular in the Middle East and starting to gain popularity several Western countries as well. It widely erroneously perceived be less harmful than other forms of tobacco use. The reproductive adverse effects cigarette have been studied before with conflicting results, but data on possible WPS are lacking. Here, we assessed nose-only exposure mainstream generated by commercially available honey-flavored "moasel" mice.The duration session was 30 min/day for one...