A5017659217- COVID-19 and healthcare impacts
- Gallbladder and Bile Duct Disorders
- Cardiac, Anesthesia and Surgical Outcomes
- Hepatocellular Carcinoma Treatment and Prognosis
- Organ Transplantation Techniques and Outcomes
- Oral and gingival health research
- Appendicitis Diagnosis and Management
- Minimally Invasive Surgical Techniques
- Trauma and Emergency Care Studies
- Chromosomal and Genetic Variations
- Surgical site infection prevention
- Hedgehog Signaling Pathway Studies
- Bariatric Surgery and Outcomes
- Salivary Gland Tumors Diagnosis and Treatment
- Hepatitis C virus research
- Genomic variations and chromosomal abnormalities
- Liver Disease Diagnosis and Treatment
- Oral and Maxillofacial Pathology
- Abdominal Surgery and Complications
- Head and Neck Cancer Studies
- Vascular Tumors and Angiosarcomas
- Pancreatitis Pathology and Treatment
- Cancer-related Molecular Pathways
- Gastrointestinal disorders and treatments
- Liver Disease and Transplantation
Alexandria University
1993-2025
Sir Charles Gairdner Hospital
2024
American University of Beirut Medical Center
2024
University of Cagliari
2023
University of Birmingham
2020-2022
Mansoura University
2013-2022
University of Michigan
2017-2022
Sinai University
2022
Institut de Virologie
2020-2021
Hospices Civils de Lyon
2019-2021
Abstract Objectives The objective of this web-based study is to analyze the attributes bariatric surgery cases ensuing health implications. Additionally, seeks delve into factors influencing post-bariatric psychological evaluations and impact various surgeries on weight loss psycho-social assessment scores for patients who had undergone within a specific center in Egypt between January 2017 2024. Methods An analytical cross-sectional recruited 411 adults different procedures by same surgical...
Recent studies have suggested the potential of mesenchymal stem cells (MSCs) to differentiate into a hepatocyte-like lineage. Here, we evaluate efficacy hepatocyte differentiation MSCs by studying acquisition features together with alteration native phenotype.In vitro, investigated protein and mRNA level expression markers mesenchymal-derived (MDHLCs) evaluated their functionality using metabolic assays. In vivo, co-expression (albumin, alpha-foetoprotein, cytokeratin 18) (fibronectin,...
Abstract Centromere defects in Systemic Sclerosis (SSc) have remained unexplored despite the fact that many centromere proteins were discovered patients with SSc. Here we report lesion skin fibroblasts from SSc show marked alterations centromeric DNA. also DNA damage, abnormal chromosome segregation, aneuploidy (only diffuse cutaneous (dcSSc)) and micronuclei (in all types of SSc), some which lose identity while retaining sequences. Strikingly, find cytoplasmic “leaking” limited (lcSSc)...
Laparoscopic adjustable gastric banding (LAGB) has high reported rates of revision due to poor weight loss (WL) and complication rates. Yet, there is yet be a consensus on the best revisional procedure after unsuccessful LAGB, studies comparing different procedures LAGB are still needed.
The centromere is the structural unit responsible for faithful segregation of chromosomes. Although regulation centromeric function by epigenetic factors has been well-studied, contributions underlying DNA sequences have much less well defined, and existing methodologies studying genomics in biology are laborious. We identified specific markers 23 24 human chromosomes that allow rapid PCR assays capable capturing genomic landscape centromeres at a given time. Use this genetic strategy can...
Abstract Centromere genomics remain poorly characterized in cancer, due to technologic limitations sequencing and bioinformatics methodologies that make high-resolution delineation of centromeric loci difficult achieve. We here leverage a highly specific targeted rapid PCR methodology quantitatively assess the genomic landscape centromeres cancer cell lines primary tissue. PCR-based profiling revealed widespread heterogeneity pericentromeric sequences cells tissues as compared healthy...
Cytogenetic analysis has detected an accumulation of genetic lesions in oral cancers. Numerical changes chromosome 17 might be associated with up-regulation p53 gene, and could contribute to critical events carcinogenesis. The aim this study was reveal possible correlations between the numerical aberrations 17, deletion or amplification P53 gene histological grading patients squamous cell carcinoma (OSCC).
This study aimed to investigate the effects of aqueous cinnamon extract (ACE) on 7, 12-Dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamster cheek pouch (HCP) mucosa. Sixty male Syrian hamsters were randomly divided into six equal groups. The groups I, II and III received no treatment, DMBA ACE respectively, for 16 weeks. Groups IV V handled as group concomitantly treated with same period additionally other weeks after stoppage application. Group VI supplementation....
OBJECTIVE The aim of the present study was to evaluate use intraoperative otoendoscopy as a factor that could influence surgical decisionmaking in cholesteatoma surgery. MATERIALS AND METHODS material this included 82 ears with acquired were operated on. They divided into 4 groups according technique chosen and endoscope. Group I 22 underwent canal wall‐down (CWD) tympanomastoid surgery, group II 20 CWD surgery endoscopy, III wall‐up (CWU) IV CWU endoscopy. Endoscopy used complementary tool...
Although rare, Complicated Meckel's diverticulum (MD) is responsible for a variety of uncommon abdominal surgical emergency presentations. Because these unique presentations, distinctive, peculiar astoundment in practice. In this article, We reviewed previously published cases with both Gastrointestinal Stromal Tumors (GISTs) and MD to define the nature pathologies their relation, character, presentation, timing diagnosis rare coincidence. illustrated relation case perforated associated...
It remains difficult to distinguish adenoid cystic carcinoma (ACC) from polymorphous low-grade adenocarcinoma (PLGA). Although these neoplasms exhibit nearly similar histologic patterns, their biologic behavior is significantly different. This study was carried out in an attempt overcome the histological overlap between tumors using immunohistochemical method for c-kit and galectin-3 proteins on twenty cases of salivary gland including twelve ACC eight PLGA. Results revealed positive...
<b>Objective:</b> Mucoepidermoid carcinoma (MEC) is the most common primary malignancy of salivary glands. Insulin-like growth factor-II mRNA-binding protein-3 (IMP3) an important prognostic factor in some cancers and a tool that differentiates between benign malignant pancreatic lesions. This study aimed to identify relationship expression IMP3 outcome gland MEC, as well differentiate MEC from pleomorphic adenoma (PA). <b>Methods:</b> Tissue specimens 70 cases 40 PA, 10 with normal were...
Long-term weight regain (WR) after sleeve gastrectomy (SG) is a major challenge. Laparoscopic banded SG (BSG) was introduced to overcome pouch dilation and, consequently, WR; however, its mid-and long-term outcomes have not been sufficiently demonstrated.This study retrospectively evaluated the mid-term loss efficacy and morbidity over at least 4-year follow-up laparoscopic using MiniMizer Gastric Ring® non-banded SG.The data of 1586 bariatric surgeries were evaluated. To ensure homogeneity...
Aim: To assess neoadjuvant conformal radiotherapy (CRT) before orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC) not suitable standard locoregional treatments. Methods: Patients undergoing OLT HCC with or without prior CRT were compared using 1:3 propensity score matching. Results: After matching, 23 patients 66 control subjects. Severe morbidity rate was 34.8 versus 24.2% in the and non-CRT groups (p = 0.289). Complete pathological response observed 47.8% of...
Abstract Background Cholangitis lenta (CL) represents a specific histological lesion associated with severe cholestasis and related to sepsis. Despite being well known by pathologists, CL has been poorly studied in liver transplantation (LT). Methods We performed retrospective 12‐year analysis of the incidence, risk factors, outcome LT recipients. Biopsy samples within 3 months after underwent blinded rereading identify recipients CL. Results Among 587 performed, 45 (7.7%) developed Of...
The advancement in medical care has led to an increase patients with acute cholecystitis (AC) and cardiopulmonary comorbidities referred for surgery. Grade II AC, according Tokyo Guidelines 2018 (TG18), is characterized by severe local inflammation no systemic affection. optimal treatment high-risk grade AC not yet been clearly established, which still a dilemma. For these patients, laparoscopic cholecystectomy (LC), despite being the only definitive treatment, challenge. introduction of...