A5032828510- Pharmacological Effects of Medicinal Plants
- Natural product bioactivities and synthesis
- Phytochemistry and Biological Activities
- Natural Antidiabetic Agents Studies
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- Phytochemicals and Antioxidant Activities
- Enzyme function and inhibition
- Bone Metabolism and Diseases
- Synthesis and biological activity
- Reproductive Biology and Fertility
- Phytochemistry and Bioactivity Studies
- Phytochemistry and Bioactive Compounds
- Chemical synthesis and alkaloids
- Phytochemistry and biological activity of medicinal plants
- Cholinesterase and Neurodegenerative Diseases
- Microbial Natural Products and Biosynthesis
- Sperm and Testicular Function
- Flavonoids in Medical Research
- SARS-CoV-2 and COVID-19 Research
- Viral gastroenteritis research and epidemiology
- Bioactive Compounds and Antitumor Agents
- Computational Drug Discovery Methods
- Synthesis and Characterization of Heterocyclic Compounds
- Heavy Metals in Plants
University of Nizwa
2016-2025
Aga Khan University
2015-2025
Guthrie Robert Packer Hospital
2017-2024
SUNY Upstate Medical University
2017-2024
University of Veterinary and Animal Sciences
2024
Bridge University
2023
University Research Co (United States)
2023
University of Malakand
2015-2023
Aga Khan University Hospital
2021
University of Houston
2021
This review aims to collect and discuss the synthetic applications of<italic>meta</italic>-chloroperbenzoic acid (<italic>m</italic>CPBA) over past few decades.
There is an ongoing hunt for biologically-active compounds that can combat phytopathogenic fungi and improve plant growth without causing any hazards to the environment. Consequently present study aims at deciphering promotion antifungal capability of Lysinibacilluys sphaericus ZA9. The bacterium was previously isolated identified in our laboratory from maize rhizosphere using 16S rRNA gene sequencing. test Lysinibacillus ZA9 found produce high quantity IAA (697 µg/ mL); siderophores (195.79...
Salmonella enterica serotype Typhi (S Typhi) is a major public health problem in low-income and middle-income countries. We aimed to investigate the effectiveness impact of typhoid conjugate vaccine Typbar-TCV against S among children an outbreak setting extensively drug-resistant (XDR) Pakistan.This cohort study was done from Feb 21, 2018, Dec 31, 2019. A census survey all households located Qasimabad Latifabad subdistricts Hyderabad, Pakistan, at baseline, 174 005 were registered census....
A new series of (S)-flurbiprofen derivatives 4a-4p and 5a-5n were synthesized with different aromatic or aliphatic aldehydes ketones to produce Schiff's bases their structures confirmed through HR-ESI-MS, 1H, 13C-NMR spectroscopy. The α-glucosidase inhibitory activities the newly compounds scrutinized, in which six 5k, 4h, 5h, 4d, 4b, 5i showed potent inhibition range 0.93 10.26 µM, respectively, whereas fifteen 4c, 4g, 4i, 4j, 4l, 4m, 4o, 4p, 5c, 5d, 5j, 5l, 5m, 5n 1 exhibited significant...
Polyhydroquinoline (PHQ) are the unsymmetrical Hantzsch derivatives of 1,4-dihydropyridines with several biological applications. In this work, twenty-five (3-27) new Schiff's base polyhydroquinoline hydrazide were synthesized in excellent to good yields by a multi-component reaction. The structures products (1-27) deduced help spectroscopic techniques, such as 1H-, 13C -NMR, and HR-ESI-MS. tested for their antibacterial vitro calcium -channel-blocking (CCB) potentials using agar-well...
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in excellent yields by treating 3,5-dibromo-4-hydroxybenzaldehyde, dimedone, ammonium acetate, and ethyl acetoacetate ethanol solvent. The structures of the compounds deduced different spectroscopic techniques such as 1H NMR, 13C HR-ESI-MS. products tested for their α-glucosidase inhibitory activity where 11 (IC50= 0.56 ± 0.01 μM), 10 0.94 4 1.47 2 2.20 0.03 6 12 2.22 0.07 7 2.76 0.04 9 2.78 3...
Thirteen novel hydrazone-Schiff bases (3-15) of fexofenadine were succesfully synthesized, structurally deduced and finally assessed their capability to inhibit urease enzyme (in vitro). In the series, six compounds 12 (IC
The fruits of four wild plants, namely, Capparis decidua, Ficus carica, Syzygium cumini , and Ziziphus jujuba are separately used as traditional dietary remedial agents in remote areas Khyber Pakhtunkhwa, Pakistan. results our study on these plants revealed that the examined were a valuable source nutraceuticals exhibited good level antimicrobial activity. investigated promising polyphenols, flavonoids, alkaloids, terpenoids, saponins. These plants' sources iron, zinc, copper, manganese,...
To assess the nutritional values and antioxidant analysis of 22 varieties date palm (Phoenix dactylifera) fruit collected from various regions Sultanate Oman. Nutritional parameters including moisture, fats, fiber, proteins, carbohydrates, energy value were determined using standard methods Association Official Analytical Chemists. The activity was screened for their free radical scavenging properties ascorbic acid as a antioxidant. Free evaluated 1,1-diphenyl-2-picrylhydrazyl radical....
Background: Infections caused by drug resistant bacteria are a major health concern worldwide and have prompted scientists to carry out efforts overcome this challenge. Researchers pharmaceutical companies trying develop new kinds of antimicrobial agents using different physical chemical methods these problems. Materials methods: In the present study, rifampicin conjugated silver (Rif-Ag) nanoparticles successfully been synthesized method. Characterization was performed UV-Vis...
Bioassay guided isolation of the methanolic extract marine macro brown alga
Hydrazides play a vital role in making biologically active compounds various fields of chemistry. These determine antioxidant, antidepressant, antimalarial, anti-inflammatory, antiglycating, and antimicrobial activity. In the present study, twenty-three new N' benzylidene-4-(tert-butyl)benzohydrazide derivatives (4-26) were synthesized by condensation aromatic aldehydes commercially available 4-(tert-butyl)benzoic acid. All target successfully from good to excellent yield; all characterized...
Background: Medication used to treat Type 2 diabetes by decreasing the absorption of carbohydrates in intestine consists α-glucosidase inhibitors. Polyhydroquinoline derivatives have attracted interest as excellent antidiabetic agents. Methods: (1–17) were synthesized and tested for vitro inhibitory activity. Results: All compounds exhibited good activity, having IC50 values from 1.23 ± 0.03 73.85 0.61 μM, compared with standard drug, acarbose. The binding mechanism these was deduced docking...
The distribution and biosynthesis of boswellic acids (BAs) is scarce in current literature. Present study aims to elucidate the BAs biosynthetic its diversity resins Boswellia sacra papyrifera. Results revealed isolation new (3β, 11β-dihydroxy BA) recently known (as source, β-boswellic aldehyde) precursors from B. resin along with α-amyrin. Following this, a detailed nomenclature was elucidated. quantification amyrins (3-epi-α-amyrin, β-amyrin α-amyrin) different showed highest amyrin as...