A5091778180- Synthesis and biological activity
- Enzyme function and inhibition
- Natural Antidiabetic Agents Studies
- Computational Drug Discovery Methods
- Cholinesterase and Neurodegenerative Diseases
- Microbial Applications in Construction Materials
- Pharmacological Effects of Medicinal Plants
- Synthesis and Characterization of Heterocyclic Compounds
- Metal complexes synthesis and properties
- Phenothiazines and Benzothiazines Synthesis and Activities
- Click Chemistry and Applications
- Crystallization and Solubility Studies
- Natural product bioactivities and synthesis
- Carbohydrate Chemistry and Synthesis
- X-ray Diffraction in Crystallography
- Nanoparticles: synthesis and applications
- Synthesis and Catalytic Reactions
- Phytochemicals and Antioxidant Activities
- Pharmacological Effects of Natural Compounds
- Medicinal Plants and Neuroprotection
- Ethnobotanical and Medicinal Plants Studies
- Essential Oils and Antimicrobial Activity
- vaccines and immunoinformatics approaches
- Advanced Photocatalysis Techniques
- Enzyme Catalysis and Immobilization
University of Nizwa
2017-2025
Korea University
2024-2025
University of Washington
2023-2024
Institute for Health Metrics and Evaluation
2023-2024
Sanjay Gandhi Post Graduate Institute of Medical Sciences
2021-2024
University of Balochistan
2023
All-Russian Scientific Research Institute of the Dairy Industry
2023
Saidu Teaching Hospital
2022
National University of Medical Sciences
2022
Khyber Medical College
2022
Abstract A library of novel bis -Schiff base derivatives based on thiobarbituric acid has been effectively synthesized by multi-step reactions as part our ongoing pursuit anti-diabetic agents. All these were subjected to in vitro α-glucosidase inhibitory potential testing after structural confirmation modern spectroscopic techniques. Among them, compound 8 (IC 50 = 0.10 ± 0.05 µM), and 9 0.13 0.03 µM) exhibited promising activity better than the standard drug acarbose 0.27 0.04 µM)....
Triterpenes possess anti-inflammatory and anti-nociceptive effects. In this study activities of Asparacosin A were evaluated` using in-vitro cyclooxygenases 1 2 (COX-1/2) inhibition assays. Moreover assessed in-vivo by carrageenan-induced paw edema test, xylene-induced ear tests, acetic acid-induced writhing formalin tests. Additionally molecular docking was conducted to elucidate the binding mechanism compound correlate findings with in-silico data. Oral administration at doses 10, 20...
A new series of (S)-flurbiprofen derivatives 4a-4p and 5a-5n were synthesized with different aromatic or aliphatic aldehydes ketones to produce Schiff's bases their structures confirmed through HR-ESI-MS, 1H, 13C-NMR spectroscopy. The α-glucosidase inhibitory activities the newly compounds scrutinized, in which six 5k, 4h, 5h, 4d, 4b, 5i showed potent inhibition range 0.93 10.26 µM, respectively, whereas fifteen 4c, 4g, 4i, 4j, 4l, 4m, 4o, 4p, 5c, 5d, 5j, 5l, 5m, 5n 1 exhibited significant...
This study deals with facile and rapid synthesis of silver nanoparticles (AgNPs) Gold (AuNPs) using Mentha longifolia leaves extracts (MLE). The synthesized AgNPs AuNPs were characterized by UV-visible spectroscopy (UV-Vis), Fourier transformed infra-red (FT-IR), atomic force microscopy (AFM) transmission electron (TEM) techniques. phytochemical analysis showed the presence bioactive secondary metabolites, which are involved in (NPs). surface plasmon resonance (SPR) observed at 435 550 nm,...
Polyhydroquinoline derivatives (1-15) were synthesized through an unsymmetrical Hantzsch reaction in excellent yields by treating 3,5-dibromo-4-hydroxybenzaldehyde, dimedone, ammonium acetate, and ethyl acetoacetate ethanol solvent. The structures of the compounds deduced different spectroscopic techniques such as 1H NMR, 13C HR-ESI-MS. products tested for their α-glucosidase inhibitory activity where 11 (IC50= 0.56 ± 0.01 μM), 10 0.94 4 1.47 2 2.20 0.03 6 12 2.22 0.07 7 2.76 0.04 9 2.78 3...
Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. Bis(dimethylamino)benzophenone derivatives 1–27 were synthesized from bis(dimethylamino)benzophenone via two-step reaction. Different spectroscopic techniques, including EI-MS and 1H NMR, employed to characterize all synthetic derivatives. The elemental composition of compounds was confirmed by analysis results found agreement with the calculated values. evaluated inhibitory activity,...
Cloud computing has emerged as a transformative force in healthcare and biomedical sciences, offering scalable, on-demand resources for managing vast amounts of data. This review explores the integration cloud within these fields, highlighting its pivotal role enhancing data management, security, accessibility. We examine application various domains, including electronic medical records, telemedicine, personalized patient care, well impact on bioinformatics research, particularly genomics,...
This research work reports the synthesis of new derivatives hydrazone Schiff bases (1–17) based on polyhydroquinoline nucleus through multistep reactions. HR-ESIMS,1H- and 13C-NMR spectroscopy were used to structurally infer all synthesized compounds lastly evaluated for prolyl oligopeptidase inhibitory activity. All prepared products displayed good excellent activity when compared with standard z-prolyl-prolinal. Three 3, 15 14 showed inhibition IC50 values 3.21 ± 0.15 5.67 0.18 µM, while...
Fluoride (F−) contamination in groundwater is a global concern arising from natural processes and human activities. This study investigates the adsorption of F− using surface-activated magnetic calcite nanocomposites (NCs) synthesized via co-precipitation assisted wet-impregnation (CP-WI). Various Fe3O4 loadings calcination temperatures (300 °C 500 °C) were explored to optimize synthesis parameters. Batch experiments conducted assess performance nanoparticles (NPs) (NCs). BET, FTIR...
Crataegus oxyacantha is an important herbal supplement and famous for its antioxidant potential. The in combination with anticholinesterase activity can be considered as target the management of Alzheimer's disease. compounds isolated from C. were evaluated cholinesterases inhibitory using Ellman's assay Galantamine standard drug. Total nine (1-9) isolated. Compounds 1 2 first time natural source. Important products like β-Sitosterol-3-O-β-D-Glucopyranoside (3), lupeol (4), β-sitosterol (5),...
Bioassay guided isolation of the methanolic extract marine macro brown alga
Monkeypox virus is an enveloped DNA that belongs to Poxviridae family. The transmitted from rodents primates via infected body fluids, skin lesions, and respiratory droplets. After being with virus, the patients experience fever, myalgia, maculopapular rash, fluid-filled blisters. It necessary differentiate monkeypox other poxviruses during diagnosis which can be appropriately envisioned analysis swab samples. During small outbreaks, treated therapies administered in orthopoxviruses...
Voriconazole (VRC) is a broad-spectrum antifungal agent belonging to BCS class II (biopharmaceutical classification system). Despite many efforts enhance its solubility, this primary issue still remains challenging for formulation scientists. Transethosomes (TELs) are one of the potential innovative nano-carriers improving solubility and permeation poorly soluble permeable drugs. We herein report voriconazole-loaded transethosomes (VRCT) fabricated by cold method followed their incorporation...
Silver nanoparticles (AgNPs) are commonly used in numerous consumer products, including textiles, cosmetics, and health care items. The widespread usage of AgNPs results their unavoidable discharge into the ecosystem, which pollutes aquatic, groundwater, sediments, marine environments. These (NPs) activate production free radicals reactive species aquatic organisms that interrupt functions DNA, cause mitochondrial dysfunction, increase lipid peroxidation, terminates development reproduction...
Kirsten rat sarcoma viral oncogene homolog (KRas) activating mutations are common in solid tumors, accounting for 90%, 45%, and 35% of pancreatic, colorectal, lung cancers (LC), respectively. Each year, nearly 150k new cases (both men women) KRas-mutated malignancies reported the United States. NSCLC (non-small cell cancer) accounts 80% all LC cases. KRas found 15% to 25% patients. The main cause is KRas-G12C mutation. drugs Sotorasib Adagrasib were recently developed treat advanced caused...