Inhibiting α-glucosidase is a reliable method for reducing blood sugar levels in diabetic individuals. Bis(dimethylamino)benzophenone derivatives 1–27 were synthesized from bis(dimethylamino)benzophenone via two-step reaction. Different spectroscopic techniques, including EI-MS and 1H NMR, employed to characterize all synthetic derivatives. The elemental composition of compounds was confirmed by analysis results found agreement with the calculated values. evaluated inhibitory activity,...

Abstract A series of novel Schiff base derivatives (1–28) 3,4-dihydroxyphenylacetic acid were synthesized in a multi-step reaction. All the bases obtained high yields and their structures determined by 1 HNMR, 13 CNMR, HR-ESI–MS spectroscopy. Except for compounds 22 , 26 27, 28, all show excellent to moderate α-glucosidase inhibition. Compounds 5 (IC 50 = 12.84 ± 0.52 µM), 4 13.64 0.58 12 15.73 0.71 16.62 0.47 15 17.40 0.74 3 18.45 1.21 7 19.68 0.82 2 20.35 1.27 µM) shows outstanding...

The current study describes the chemical profiles and biological activities of essential oils (EOs) from Ziziphus leucodermis stem leaves for first time. Higher quantity β‐eudesmol was found in (43.4 ± 0.68%) compared to leave’s oil, while contained higher amount α‐bergamotene (13.5 0.65%), β‐eudesmene (7.4 0.51%) stem. Significant potential shown by oil having IC50 133.5 0.80 µg/mL than (IC50 = 210.4 0.20 µg/mL) against breast cancer (MDA‐MB‐231) cells. Similarly, inhibition observed (IC50,...

Berberis lyceum Royle has such pronounced medicinal values that it is used as cure of many diseases and exhibited great therapeutic effects among the local communities throughout world. The present research was carried out to evaluate quantitative ethnobotanical status phytochemical analysis B. lyceum. Regular field trips were arranged study area (Shangla District) in August 2017 October 2019 interviews with 100 residents (age range: 30 50 years) conducted. approach adopted for data...

Morpholine based thiazoles have been reported as bovine carbonic anhydrase CA-II inhibitors.

Background: Results of our previous studies on antiglycation activity, and the noncytotoxicity 2-mercapto benzothiazoles, encouraged us to further widen investigation towards identification leads against diabetes mellitus. Methods: 33 derivatives benzothiazoles 1-33 were evaluated for in vitro α- glucosidase inhibitory activity. Mode inhibition was deduced by kinetic studies. To predict interactions benzothiazole with binding pocket α-glucosidase enzyme, molecular docking performed selected...

Background: Ferula ammoniacum (D. Don) is one of the endemic medicinal plants that traditionally used to treat a number diseases. Although plant has been enhance memory, investigational evidence supporting nootropic effect was unsubstantial. Hence, rationale for this study assess potential beneficial F. seed extracts on learning and memory in mice. Methods: The powdered samples (aerial parts) were subjected extraction ad fractionation. Among extracts, crude ethyl acetate screened major...

18β-Glycyrrhetinic acid (18β-GA) is known for several biological activities, and has been the focus of extensive research development therapeutic agents. In current study, 18β-GA-peptide conjugates 2-11 were evaluated their in vitro α-glucosidase inhibitory antiglycation activities. Structure-activity relationship (SAR) established molecular interactions active bioconjugates with enzyme's binding sites predicted through modeling approach. tripeptide moiety 2-11, peptide residue at position 1...

The present analysis explores the chemical constituents and determines in vitro antimicrobial, antidiabetic, antioxidant significance of essential oils (EOs) stem, leaves, flowers Ochradenus arabicus for first time. EOs presented seventy-four contributing to 81.46% total EOs, with major compounds being 24-norursa-3,12-diene (13.06%), 24-norursa-3,12-dien-11-one (6.61%), 24-noroleana-3,12-diene (6.25%). stem sixty-one contributed 95.95% oil, whose main bioactive were (+)-camphene (21.50%),...

The essential oils (EOs) of the stem (SEO) and leaves (LEO) Zygophyllum qatarense were analysed by GC/MS. Seventeen compounds comprising 94.0% total oil composition identified in (LEO), while eleven accounting 100% detected (SEO). main constituents LEO methyl-8-pimaren-18-oate (33.09%), methyl palmitate (10.55%), linolenate (7.67%), 6,6-dimethylhept-1-en-4-yne (7.45%) caryophyllene (6.14%). SEO was found rich urs-12-en-28-ol (21.81%), followed 15-bromopentadecan-1-ol (13.67%),...

Developing a medication to cure and manage diabetes mellitus complications is of interest in medicinal chemistry. Toward this end, six bis-biphenyl-salicylaldehyde Schiff base derivatives have been evaluated for their α-glucosidase inhibition, antiglycation anti-inflammation potentials. Four compounds (compounds 2-5) showed an excellent inhibitory effect superior that produced by acarbose. Additionally, the docking study revealed these are anchored within binding pocket via hydrogen bonding,...

The current research was designed to explore the Blepharispermum hirtum Oliver (Asteraceae) stem and leaves essential oil (EO) composition extracted through hydro-distillation using gas chromatography-mass spectrometry (GC-MS) analysis for first time. EOs of B. were comparatively studied in vitro antidiabetic anticancer potential α-glucosidase an MTT inhibition assay, respectively. In both tested samples, same number fifty-eight compounds identified contributed 93.88% 89.07% total...

Abstract We aimed to characterize the relationship of oral microbiome with diabetes in Pakistan. Saliva samples were collected from diabetic patients (n = 49) and healthy individuals 55). 16S metagenomics saliva was carried out by NGS technology. observed that phylum Firmicutes (p-value 0.024 at 95% confidence interval) significantly more abundant among than controls. found abundance Actinobacteria did not vary both groups contrast a similar report USA (Long et al., 2017). On genus level,...

AbstractCommiphora foliacea Sprague and related species are renowned for the expensive perfumes, cosmetics, aromatherapy due to its pleasant smell of essential oils used promote relaxation, reduce stress, improve memory loss. The chemical ingredients from stem C. oil (EO) were evaluated GC-MS analysis, in vitro (antioxidant, antimicrobial, antidiabetic, carbonic anhydrase-II (CA-II)) vivo (anti-analgesic anti-inflammatory) studies. EO encompasses 56 compounds contributed 93.58% total with...

Hepatitis C virus (HCV), which infected 71 million worldwide and about 5%–6% are from Pakistan, is an ssRNA virus, responsible for end‐stage liver disease. To date, no effective therapy available to cure this Hence, it important study the most prevalent genotypes infecting human population design novel vaccine or small molecule inhibitors control infections associated with HCV. Therefore, in clinical samples (n = 35; HCV-3a) HCV patients were subjected Sanger sequencing method. The of core...

All living things contain liquid inside their bodies which serves many functions like blood act as important connective tissue in transport of oxygen to all the cells similarly excrete waste material from cell outside body. Blood a red colored pigment is called hemoglobin and its central portion iron, when level haemoglobin falls body this condition anemia. To find actual type anemia different types tests are conducted person suffers. Most pregnant women suffer with deficiency iron. A study...

<title>Abstract</title> Despite of having rich reptilian fauna, the wild Pakistani lizards remained unexplored for blood borne parasites. Hence, this study was designed to report molecular prevalence and phylogenetic evaluation <italic>Hepatozoon ophisauri</italic>and <italic>Toxoplasma gondii</italic> in samples (N = 101) that were trapped from various areas different altitudes (ranging between 1200 2250 m above sea level) Khyber Pakhtunkhwa province Pakistan during March 2022 till June...