G. Mostafa

ORCID: 0000-0002-2912-3173
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About
Contact & Profiles
Research Areas
  • Crystallization and Solubility Studies
  • X-ray Diffraction in Crystallography
  • Analytical Chemistry and Sensors
  • Crystallography and molecular interactions
  • Analytical Methods in Pharmaceuticals
  • Electrochemical sensors and biosensors
  • Antibiotics Pharmacokinetics and Efficacy
  • Electrochemical Analysis and Applications
  • Analytical Chemistry and Chromatography
  • Molecular Sensors and Ion Detection
  • Crystal structures of chemical compounds
  • Metal complexes synthesis and properties
  • Nonlinear Optical Materials Research
  • Synthesis and Characterization of Heterocyclic Compounds
  • Synthesis and biological activity
  • Conducting polymers and applications
  • Free Radicals and Antioxidants
  • Photochemistry and Electron Transfer Studies
  • Analytical chemistry methods development
  • Electrolyte and hormonal disorders
  • Quinazolinone synthesis and applications
  • Chronic Myeloid Leukemia Treatments
  • Structural and Chemical Analysis of Organic and Inorganic Compounds
  • Luminescence and Fluorescent Materials
  • Phenothiazines and Benzothiazines Synthesis and Activities

King Saud University
2016-2025

Nile University
2024

Cairo University
2024

National Water Research Center
2003-2023

National Research Centre
2006-2022

Riyadh Elm University
2019-2020

Agricultural Research Center
2016-2020

Assiut University
2019

Suez Canal University
1998-2012

Bioanalytica (Switzerland)
2001-2003

A literature survey revealed no suitable "reversed phase-high performance thin layer chromatography (RP-HPTLC)" method for the analysis of rivaroxaban in nanoparticle (NP) formulations. Therefore, a novel rapid, simple, economical and environment friendly RP-HPTLC has been established quantification NP formulations commercial tablets. was performed using "RP-18 silica gel 60 F254S HPTLC plates". The binary mixture green solvents ethanol : water (7 3 v/v) utilized as mobile phase. carried out...

10.1039/c9ra07825h article EN cc-by-nc RSC Advances 2020-01-01

Background: Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family Asteraceae, which used in traditional medicines. Aim of study: This work was undertaken study chemical composition, analgesic, anti-inflammatory, and wound healing properties hydroalcoholic extracts different parts (roots, seeds, leaves, capitula) A. pyrethrum. Material Methods: The phytochemical analysis studied conducted by GC-MS. analgesic activity evaluated mice using acetic acid formaldehyde...

10.3390/molecules25225469 article EN cc-by Molecules 2020-11-23

In this work, two varieties of Anacyclus pyrethrum (L.) including var. and depressus (Ball) Maire were evaluated for their mineral chemical compositions, total phenolic flavonoid contents, antimicrobial antioxidant activities using hydroalcoholic extracts from different parts (leaves, capitula, roots, seeds). The phytochemical compositions carried out standard methods. activity was determined the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis 3-ethylbenzothiazolin-6-sulfonic...

10.3390/plants10010149 article EN cc-by Plants 2021-01-13

Caralluma europaea (Guss.) N.E.Br.: (C. europaea) is a wild medicinal plant belonging to the family Apocynaceae. It commonly used in traditional medicines for treating several diseases. The present work aims evaluate anti-inflammatory, antibacterial, and antifungal potentials of C. fractions including hydro ethanol (ET CE), n-butanol (But polyphenol (Poly CE). chemical composition hydroethanol, n-butanol, polyphenol-rich from were determined using GC-MS after silylation. anti-inflammatory...

10.3390/molecules26030636 article EN cc-by Molecules 2021-01-26

This work was conducted to study the chemical composition, antioxidant, antibacterial, and antifungal activities of essential oil hydrolat from Withania frutescens. The extracted by hydrodistillation. characterization performed using gas chromatography-mass spectrometry (GC/MS). antioxidant activity studied four different assays (DPPH, TAC, FRAP, β-carotene bleaching). antibacterial test carried out on multidrug-resistant bacteria including Gram-negative Gram-positive strains. Antifungal...

10.3390/app11115168 article EN cc-by Applied Sciences 2021-06-02

A cyclobenzaprine-tetraphenylborate (CBP-TPB) complex was synthesized, achieving a 78% yield through an anion exchange reaction. The white crystals of the were formed in acetonitrile and characterized using variety spectroscopic analytical techniques, including ultraviolet, infrared, mass, elemental, nuclear magnetic resonance (NMR) spectroscopy, as well X-ray crystallography. study employed comprehensive approach to investigate structural properties, stability, behavior CBP-TPB complex. use...

10.3390/cryst13071088 article EN cc-by Crystals 2023-07-12

10.1016/bs.podrm.2015.02.001 article EN Profiles of drug substances, excipients, and related methodology 2015-01-01

In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (α-amylase α-glucosidase). The compound also tested its vivo antidiabetic using Sprague-Dawley rats as experimental animals. effects various doses STZ (Streptozotocin) induced diabetic on fasting blood glucose level, body weight, lipid parameters, hepatic enzymes, renal functions were the reported protocols. CTN exhibited highest...

10.3390/molecules26010137 article EN cc-by Molecules 2020-12-30

Hydrazinobenzoic acid derivatives with isothiocyanate, benzylidene, and anhydride core units (1-13) were previously synthesized fully characterized. Targets 1-13 investigated for their antioxidant activities using different in vitro assays such as 1,1-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging, 2,2'-azino-bis(3-ethylbenzothiazoline-6-sulfonate) (ABTS), ferric reducing power (FRAP), capability. All showed properties relation to the standard butylated hydroxylanisole (BHA). Superior...

10.1021/acsomega.1c04772 article EN cc-by-nc-nd ACS Omega 2021-11-17

Sapitinib (AZD8931, SPT) is a tyrosine kinase inhibitor of the epidermal growth factor receptor (EGFR) family (pan-erbB). In multiple tumor cell lines, STP has been shown to be much more potent EGF-driven cellular proliferation than gefitinib. current study, highly sensitive, rapid, and specific LC-MS/MS analytical method for estimation SPT in human liver microsomes (HLMs) was established with application metabolic stability assessment. The validated terms linearity, selectivity, precision,...

10.3390/molecules28052322 article EN cc-by Molecules 2023-03-02

Abstract The study introduces a novel ionic compound, 1‐(3‐chloropropyl)piperidin‐1‐ium tetraphenylborate (NCPP‐TPB), synthesized and characterized through an integrated approach of spectroscopic, crystallographic, computational analyses. Single‐crystal X‐ray diffraction confirmed the compound's solid‐state structure, emphasizing its intricate hydrogen bonding noncovalent interactions, which ensure structural stability. Hirshfeld surface QTAIM analyses quantitatively, evaluated these...

10.1002/slct.202404452 article EN ChemistrySelect 2025-01-01

The detection of HC(S)CN in TMC-1 suggests that HC(S)NC may also exist. To aid its possible detection, and deuterated isotopologue DC(S)NC were investigated via high-level ab initio methods, specifically CCSD(T) CCSD(T)-F12. By utilizing multidimensional potential energy surfaces derived from explicitly correlated coupled-cluster calculations, we analyzed their geometrical parameters, vibrational frequencies, rotational constants, a comprehensive set spectroscopic constants generated the...

10.1063/5.0246410 article EN The Journal of Chemical Physics 2025-01-28

Comprehensive experimental and theoretical studies were executed to get an insight into the nature of charge transfer in acebutolol tetraphenylborate complex.

10.1039/d4ra07163h article EN cc-by-nc RSC Advances 2025-01-01

Abstract The synthesis of 4,5‐bis(hydroxymethyl)‐2‐methylpyridin‐3‐ol tetraphenylborate complex in water using an anion exchange process yielded more than 76 %. resulting white was obtained and characterized various spectroscopic analytical techniques, including ultraviolet, infrared radiation (IR), mass, elemental analysis, nuclear magnetic resonance (NMR). antimicrobial activity the formed ion‐associate evaluated. structural, electrical, bonding properties a novel...

10.1002/open.202400422 article EN cc-by ChemistryOpen 2025-02-10

The fluorescent-stain photos of the treated HCT-116 cells with Pd( ii ) complex 2′,6′-di(thiazol-2-yl)-2,4′-bipyridine showed increased apoptotic bodies, indicating both early (18%) and late apoptosis (32%) as well a necrosis ratio about 10%.

10.1039/d5ra00647c article EN cc-by-nc RSC Advances 2025-01-01

Lake Manzala is the largest and most productive lake of Egypt's northern coastal lakes has socio-economic impacts. Pollution by heavy metals significant type pollution worldwide, particularly in Manzala, which receives mixed discharges from densely populated areas. Water samples were collected at twelve sites around winter summer 2015. Samples Eichhornia crassipes winter, Oreochromis niloticus two (8 10). V, Cr, Mn, Fe, Co, Ni, Cu, Zn analysed these using inductively coupled plasma-mass...

10.1016/j.heliyon.2019.e02276 article EN cc-by-nc-nd Heliyon 2019-08-01

Berberis lyceum Royle has such pronounced medicinal values that it is used as cure of many diseases and exhibited great therapeutic effects among the local communities throughout world. The present research was carried out to evaluate quantitative ethnobotanical status phytochemical analysis B. lyceum. Regular field trips were arranged study area (Shangla District) in August 2017 October 2019 interviews with 100 residents (age range: 30 50 years) conducted. approach adopted for data...

10.3390/agronomy11010130 article EN cc-by Agronomy 2021-01-11

Background: Olea europea L. subsp. europaea var. sylvestris (Mill) Lehr (Oleaster) is a wild endemic olive tree indigenous to the Mediterranean region. leaves represent natural reservoir of bioactive molecules that can be used for therapeutic purposes. Aim study: This work was conducted study antidiabetic and antihyperglycemic activities flavonoids from oleaster using alloxan-induced diabetic mice. The mode action against eight receptors have high impact on diabetes management complication...

10.3390/molecules25215073 article EN cc-by Molecules 2020-11-01
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