A5037795851- Analytical Methods in Pharmaceuticals
- Antibiotics Pharmacokinetics and Efficacy
- Analytical Chemistry and Chromatography
- Drug Solubulity and Delivery Systems
- Advanced Drug Delivery Systems
- Chronic Lymphocytic Leukemia Research
- Quinazolinone synthesis and applications
- Drug-Induced Hepatotoxicity and Protection
- Chronic Myeloid Leukemia Treatments
- Synthesis and biological activity
- Analytical Chemistry and Sensors
- Neuroscience and Neuropharmacology Research
- PI3K/AKT/mTOR signaling in cancer
- Pharmacological Effects of Natural Compounds
- Antimicrobial Resistance in Staphylococcus
- Hormonal and reproductive studies
- HIV/AIDS drug development and treatment
- Natural Antidiabetic Agents Studies
- Forensic Toxicology and Drug Analysis
- Lipid Membrane Structure and Behavior
- Phenothiazines and Benzothiazines Synthesis and Activities
- Ethnobotanical and Medicinal Plants Studies
- Pharmacological Effects and Toxicity Studies
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
King Saud University
2014-2023
National Organization for Drug Control and Research
1994-2021
Riyadh Elm University
2020
Al-Azhar University
2017
Apremilast (APM) is a novel, orally administered small molecule drug approved for treatment of psoriasis or psoriatic arthritis. Due to its low solubility and permeability, it classified as class IV according BCS classification. Dose titration recommended during APM due tolerability twice-daily dosing regimen issues.In this study, three different APM-loaded PLGA nanoparticles (F1-F3) were prepared by single emulsion evaporation method. Based on particle size, PDI, zeta potential (ZP),...
Abstract Objective The current studies were undertaken to enhance dissolution and bioavailability/pharmacokinetic profile of a newly approved anticancer drug ibrutinib (IBR) via encapsulation into self-nanoemulsifying delivery system (SNEDDS). Methods Various SNEDDS formulations IBR developed by aqueous phase titration method using Capryol-PGMC (oil phase), Tween-20 (surfactant), Carbitol (cosurfactant) water (aqueous phase). Developed was evaluated in vitro for various physicochemical...
A literature survey revealed no suitable "reversed phase-high performance thin layer chromatography (RP-HPTLC)" method for the analysis of rivaroxaban in nanoparticle (NP) formulations. Therefore, a novel rapid, simple, economical and environment friendly RP-HPTLC has been established quantification NP formulations commercial tablets. was performed using "RP-18 silica gel 60 F254S HPTLC plates". The binary mixture green solvents ethanol : water (7 3 v/v) utilized as mobile phase. carried out...
Background: Anacyclus pyrethrum (A. pyrethrum) is a wild species belonging to the family Asteraceae, which used in traditional medicines. Aim of study: This work was undertaken study chemical composition, analgesic, anti-inflammatory, and wound healing properties hydroalcoholic extracts different parts (roots, seeds, leaves, capitula) A. pyrethrum. Material Methods: The phytochemical analysis studied conducted by GC-MS. analgesic activity evaluated mice using acetic acid formaldehyde...
In this work, two varieties of Anacyclus pyrethrum (L.) including var. and depressus (Ball) Maire were evaluated for their mineral chemical compositions, total phenolic flavonoid contents, antimicrobial antioxidant activities using hydroalcoholic extracts from different parts (leaves, capitula, roots, seeds). The phytochemical compositions carried out standard methods. activity was determined the DPPH (2,2-diphenyl-1-picrylhydrazyl), ABTS (2,2-azino-bis 3-ethylbenzothiazolin-6-sulfonic...
Caralluma europaea (Guss.) N.E.Br.: (C. europaea) is a wild medicinal plant belonging to the family Apocynaceae. It commonly used in traditional medicines for treating several diseases. The present work aims evaluate anti-inflammatory, antibacterial, and antifungal potentials of C. fractions including hydro ethanol (ET CE), n-butanol (But polyphenol (Poly CE). chemical composition hydroethanol, n-butanol, polyphenol-rich from were determined using GC-MS after silylation. anti-inflammatory...
This work was conducted to study the chemical composition, antioxidant, antibacterial, and antifungal activities of essential oil hydrolat from Withania frutescens. The extracted by hydrodistillation. characterization performed using gas chromatography-mass spectrometry (GC/MS). antioxidant activity studied four different assays (DPPH, TAC, FRAP, β-carotene bleaching). antibacterial test carried out on multidrug-resistant bacteria including Gram-negative Gram-positive strains. Antifungal...
The incidence of diabetes is increasing worldwide. Chronic neuropathic pain occurs in approximately 25% diabetic patients. Tramadol, an atypical analgesic with a unique dual mechanism action, used the management painful neuropathy. It acts on monoamine transporters to inhibit reuptake norepinephrine (NE), serotonin (5-HT), and dopamine (DA). purpose this study was evaluate effects brain neurotransmitter alterations induced by tramadol rats, hepatic renal toxicities drug. Eighty...
Eluxadoline is a newly approved orally administered drug used for the treatment of Irritable Bowel Syndrome with Diarrhea. It reported as poorly water-soluble due to which its dissolution rate and oral bioavailability are very poor. In this work, various plain PLGA nanoparticles (NPs) (F1-F4) were prepared optimized based on particle size, PDI, zeta potential percent entrapment efficiency (EE). The developed NPs showed average size ranging from 260.19 279.76 nm smooth surface EE...
In this study, catechin (CTN) isolated from Elaeagnus umbellata was evaluated for in vitro antioxidant potential and inhibition of carbohydrate digestive enzymes (α-amylase α-glucosidase). The compound also tested its vivo antidiabetic using Sprague-Dawley rats as experimental animals. effects various doses STZ (Streptozotocin) induced diabetic on fasting blood glucose level, body weight, lipid parameters, hepatic enzymes, renal functions were the reported protocols. CTN exhibited highest...
Berberis lyceum Royle has such pronounced medicinal values that it is used as cure of many diseases and exhibited great therapeutic effects among the local communities throughout world. The present research was carried out to evaluate quantitative ethnobotanical status phytochemical analysis B. lyceum. Regular field trips were arranged study area (Shangla District) in August 2017 October 2019 interviews with 100 residents (age range: 30 50 years) conducted. approach adopted for data...
As part of our search for new compounds having antiviral effects, the prepared 2-aminonaphthalimide series was examined its activity against herpes simplex viruses HSV-1 and HSV-2. This represents first study effects this class compounds. The 2-amino-1H-benzo[de]isoquinoline-1,3-diones HSV-2 using a cytopathic effect inhibition assay. In terms effective concentration (EC50), furaldehyde, thiophene aldehyde allyl isothiocyanide derivatives 14‒16 showed potent (EC50 = 19.6, 16.2 17.8 μg/mL),...
Montelukast is a leukotriene receptor antagonist for treatment of asthma, gliclazide an oral hypoglycemic antidiabetic agent, and nifedipine calcium channel blocker used angina pectoris hypertension. These drugs may be prescribed to patients suffering from these chronic diseases. A survey the literature reveals that there no reported method simultaneous determination montelukast, gliclazide, in pharmaceutical preparations or biological fluids.A simple, sensitive, rapid quantification human...
Delafloxacin (DFL) is a novel potent and broad-spectrum fluoroquinolone group of antibiotics effective against both Gram-positive negative aerobic anaerobic bacteria. In this study, DFL-loaded stearic acid (lipid) chitosan (polymer) hybrid nanoparticles (L-P-NPs) have been developed by single-emulsion-solvent evaporation technique. The mean particle size polydispersity index (PDI) optimized L-P-NPs (F1-F3) were measured in the range 299-368 nm 0.215-0.269, respectively. drug encapsulation...
Delafloxacin (DLX) is a recently-approved fluoroquinolone antibiotic, which recommended for the treatment of “acute bacterial skin and structure infections”. A thorough literature survey revealed only single published method estimation DLX using UPLC-MS/MS technique in biological samples. There no high-performance thin-layer chromatography (HPTLC) has been reported dosage forms and/or Therefore, selective, sensitive, rapid validated HPTLC-densitometry used human plasma first time. HPTLC...
Background: Olea europea L. subsp. europaea var. sylvestris (Mill) Lehr (Oleaster) is a wild endemic olive tree indigenous to the Mediterranean region. leaves represent natural reservoir of bioactive molecules that can be used for therapeutic purposes. Aim study: This work was conducted study antidiabetic and antihyperglycemic activities flavonoids from oleaster using alloxan-induced diabetic mice. The mode action against eight receptors have high impact on diabetes management complication...
In this work; delafloxacin (DLFX) was determined using a validated green RP-HPTLC and NP-HPTLC methods in commercial tablets in-house developed solid lipid nanoparticles (SLNs). determination of DLFX performed "RP-18 silica gel 60 F254S HPTLC plates". However; estimation "silica For method; the ternary combination ethanol:water:ammonia solution (5:4:2
Purpose: To develop new sensitive, accurate, rapid and reproducible high performance liquid chromatography (HPLC) method to determine metronidazole levels in human plasma apply the a bioequivalence study.Methods: Metronidazole was extracted from through one step of protein precipitation by methanol using carbamazepine as internal standard (IS). After centrifugation sample, supernatant layer separated injected into HPLC system Eclipse XDB-phenyl column. The mobile phase consisted phosphate...