A5113987260- Natural Compound Pharmacology Studies
- Tuberculosis Research and Epidemiology
- Natural product bioactivities and synthesis
- Mycobacterium research and diagnosis
- Nanoparticles: synthesis and applications
- Phytochemistry and Biological Activities
- Biological Activity of Diterpenoids and Biflavonoids
- Chemical Synthesis and Analysis
- Phytochemicals and Antioxidant Activities
- Natural Antidiabetic Agents Studies
- Infectious Diseases and Tuberculosis
- Acute Myeloid Leukemia Research
- Advanced Nanomaterials in Catalysis
- Medicinal Plants and Neuroprotection
- Heavy Metals in Plants
- Graphene and Nanomaterials Applications
- Single-cell and spatial transcriptomics
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Chronic Lymphocytic Leukemia Research
- Membrane Separation Technologies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Glycogen Storage Diseases and Myoclonus
- Computational Drug Discovery Methods
- Microbial Natural Products and Biosynthesis
University of Haripur
2015-2025
International Center for Chemical and Biological Sciences
2021-2024
University of Karachi
2021-2024
COMSATS University Islamabad
2024
Services Hospital
2024
Khyber Medical University
2024
Kohat University of Science and Technology
2017
Pir Mehr Ali Shah Arid Agriculture University
2013
Globally, urinary tract infection (UTI) is considered a major public health concern and the second most common bacterial affecting individuals of different ages. Bacteria are responsible for about 95% UTIs. The emergence antimicrobial resistance in uropathogens may lead to poor treatment outcomes with knowledge microorganism involves antibiograms important empirical A cross-sectional study was carried out over 7 months (January July 2019) focus on identification pathogens causing UTI...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis , ranks among the top causes of global human mortality, as reported World Health Organization’s 2022 TB report. The prevalence M. strains that are multiple and extensive-drug resistant represents a significant barrier to eradication. Fortunately, having many completely sequenced genomes available has made it possible investigate species pangenome, conduct pan-phylogenetic investigation, find potential new drug targets. 442...
Mycobacterium tuberculosis complex (MTBC) Lineage 3 (L3) strains are abundant in world regions with the highest burden. To investigate population structure and global diversity of this major lineage, we analyzed a dataset comprising 2682 L3 from 38 countries over 5 continents, by employing 24-loci mycobacterial interspersed repetitive unit-variable number tandem repeats genotyping (MIRU-VNTR) drug susceptibility testing. We further combined whole-genome sequencing (WGS) phylogeographic...
Highly variable response shown by individuals against mosquito-borne infections suggests that host genetic factors play an important role in determining disease onset. Therefore, it is necessary to determine the risk of these diseases specific populations. The current study aimed percentage general population carrying susceptibility and protection-related variants. This initially aggregated variants from all publically available data literature. Afterward, allele frequency was calculated...
Piper longum (long pepper) in dried form is used several traditional medicines and as a spice. The present study highlights nutritional toxic elements content, synthesis, characterization of silver, copper oxide, nickel nanoparticles using P. catkin extract. also determined anticancer, antioxidant, antimicrobial, redox catalytic activities the synthesized NPs. extract mediated (PLNPs) at different pH ratios were characterized by UV–Vis (ultra-violet-visible), FT-IR (Fourier-Transform...
Abstract Tuberculosis (TB), caused by Mycobacterium tuberculosis bacteria, is a leading infectious cause of mortality worldwide, including in Pakistan. Drug resistant M. an emerging threat for TB control, making it important to detect the underlying genetic mutations, and thereby inform treatment decision prevent transmission. Whole genome sequencing has emerged as new diagnostic reliably predict drug resistance within clinically relevant time frame, its deployment will have greatest impact...
The genus Garcinia is reported to possess antimicrobial, anti‐inflammatory, anticancer, hepatoprotective and anti‐HIV activities. hombroniana in Malaysia used treat itching as a protective medicine after child birth. This study was aimed isolate the chemical constituents from bark of G . explore their possible pharmacological potential. Ethyl acetate extract afforded one new (1) six (2–7) known 3 → 8 rotameric biflavonoids. Their structures were elucidated by UV, IR NMR (1D 2D) spectroscopy...
This study reports a facile synthesis of silver nanoparticles (C3-AgNPs) by chemical route, using C3; 2,2′-((1E,1′E)-(propane-1,3-diylbis(azanylylidene))bis(methanylylidene))diphenol (3) and nitrate. The formation was monitored UV–Vis spectroscopy the appearance typical surface plasmon absorption maxima. synthesized C3-AgNPs were characterized Fourier-Transform-infrared (FTIR) atomic force microscopy (AFM) techniques. In addition, effect concentration, temperature, time, pH, stability in...
Abstract Tuberculosis is a communicable disease with high morbidity and mortality rates in developing countries. The study's primary objective to compare conventional methods such as acid-fast bacillus (AFB) culture microscopy rapid diagnostic methods. secondary histopathological microbiological findings suspected patients tubercular lymphadenitis. A total of 111 samples (August 2018 September 2019) lymph nodes were processed for AFB microscopy, cultures, drug-susceptibility testing (DST),...
The study describes the content of macro, micro, and trace essential toxic elements in thirteen medicinal herbs their products including Acorus calamus, Blepharis edulis, Caesalpinia bonducella, Curculigo orchioides, Helicteres isora, Holarrhena pubescens, Pastinaca sativa, Pistacia integerrima, Quercus infectoria, Rauwolfia serpentina, Saussurea lappa, Teucrium stocksianum, Xanthium strumarium available local markets Pakistan. elemental were analyzed with techniques inductively coupled...
Non-coding RNAs (ncRNAs) can control the flux of genetic information; affect RNA stability and play crucial roles in mediating epigenetic modifications. A number studies have highlighted potential both virus-encoded host-encoded ncRNAs viral infections, transmission therapeutics. However, role an emerging type non-coding transcript, circular (circRNA) severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been fully elucidated so far. Moreover, pathogenic...
The dichloromethane bark extract of Garcinia hombroniana yielded one new cycloartane triterpene; (22Z,24E)-3β-hydroxycycloart-14,22,24-trien-26-oic acid (1) together with five known compounds: garcihombronane G (2), J (3), 3β acetoxy-9α-hydroxy-17,14-friedolanostan-14,24-dien-26-oic (4), (22Z, 24E)-3β, 9α-dihydroxy-17,14-friedolanostan-14,22,24-trien-26-oic (5) and 3β, 23α-dihydroxy-17,14-friedolanostan-8,14,24-trien-26-oic (6). Their structures were established by the spectral techniques...
18β-Glycyrrhetinic acid (18β-GA) is known for several biological activities, and has been the focus of extensive research development therapeutic agents. In current study, 18β-GA-peptide conjugates 2-11 were evaluated their in vitro α-glucosidase inhibitory antiglycation activities. Structure-activity relationship (SAR) established molecular interactions active bioconjugates with enzyme's binding sites predicted through modeling approach. tripeptide moiety 2-11, peptide residue at position 1...
AbstractGarcinia species are reported to possess antimicrobial, anti-inflammatory, anticancer, anti-HIV and anti-Alzheimer's activities. This study aimed investigate the in vitro cholinesterase enzyme inhibitory activities of garcihombronane C (1), F (2), I (3), N (4), friedelin (5), clerosterol (6), spinasterol glucoside (7) 3β-hydroxy lup-12,20(29)-diene (8) isolated from Garcinia hombroniana, perform molecular docking simulation get insight into binding interactions ligands enzymes. The...
In the face of rising threat resistant pathogens, antimicrobial peptides (AMPs) offer a viable alternative to current challenge due their broad-spectrum activity. This study focuses on enhancing efficacy temporin-SHa derived NST-2 peptide (1), which is known for its and anticancer activities. We synthesized new analogs 1 using three strategies, i.e. retro analog preparation, lysine addition/substitution, levofloxacin conjugation. Analogs were tested in term antibacterial, antifungal, Analog...