A5069027341- Natural Antidiabetic Agents Studies
- Drug-Induced Hepatotoxicity and Protection
- Vitamin D Research Studies
- Mass Spectrometry Techniques and Applications
- Bone health and osteoporosis research
- Phytochemicals and Antioxidant Activities
- Enzyme Production and Characterization
- Phosphodiesterase function and regulation
- Enzyme function and inhibition
- Biofuel production and bioconversion
- Plant Reproductive Biology
- Genetic diversity and population structure
- Curcumin's Biomedical Applications
- Cholinesterase and Neurodegenerative Diseases
- Drug Transport and Resistance Mechanisms
- Enzyme Catalysis and Immobilization
- Microbial Metabolic Engineering and Bioproduction
- Essential Oils and Antimicrobial Activity
- Pancreatic function and diabetes
- Alzheimer's disease research and treatments
- Vitamin C and Antioxidants Research
- Biochemical and Molecular Research
- Moringa oleifera research and applications
- Microbial bioremediation and biosurfactants
- Iron Metabolism and Disorders
King Abdulaziz University
2013-2022
University of Peshawar
2013
University of Veterinary and Animal Sciences
2010
King Abdul Aziz University Hospital
2007-2010
Aga Khan University Hospital
2006
Swansea University
1988-1999
University of Wales
1999
University of Nottingham
1988
Chewing stick (miswak Salvadora persica L.) is an effective tool for oral hygiene. It possessed various biological properties including significant antibacterial and anti-fungal effects. In the present study, we evaluated antioxidant compounds in miswak. Miswak root was extracted with 80% methanol. Methanol extract as by using DPPH, ABTS phosphomolybdenum complex assays analysis GC-MS. Peroxidase, catalase polyphenoloxidase were performed crude of miswak root. The methanol contained highest...
α-Amylase from Trichoderma harzianum was covalently immobilized on activated wool by cyanuric chloride. Immobilized α-amylase exhibited 75% of its initial activity after 10 runs. The soluble and α-amylases maximum at pH values 6.0 6.5, respectively. enzyme more thermally stable than the one. Various substrates were hydrolyzed with high efficiencies compared to those α-amylase. inhibition metal ions low as enzyme. On basis results obtained, could be employed in saccharification starch processing.
Garcinia mangostana L. (Fruit) has been commonly used as folklore drug in the treatment of various types diseases. The present experiment was designed to evaluate potential effect α-mangostin mediated pharmacological modulation hepatic carbohydrate metabolism streptozotocin (STZ) induced diabetic rats. Oral glucose tolerance test (OGTT) performed normoglycemic Single intraperitoneal injection STZ (60 mg/kg, body weight) for induction diabetes Swiss albino (Wistar strain) rats were divided...
Alendronate belongs to a class of drugs called bisphosphonates. Bisphosphonates (BP) therapy is vital option reduce the risk bone fracture in people who suffer from osteoporosis. Yet, bisphosphonate have displayed several side effects. Lepidium sativum (LS) seeds been used traditional folk medicine heal fractured bones. However, there dearth information on impact LS metabolism especially cases glucocorticoids induced Therefore, aim study was compare biochemical markers and histological...
Purpose: To identify the frequency, levels and predictors of potential drug-drug interactions (pDDIs) in a pediatrics ward teaching hospital Pakistan.Methods: Medication profiles 400 pediatric patients were evaluated for pDDIs using Micromedex Drug-Reax® software. Logistic regression was used to association with hospital-stay, patient’s gender, number medications.Results: In total, 86 interacting drug-combinations resulting 260 identified. Overall, 25.8 % exposed at least one pDDI regardless...
Thymoquinone (TQ), a natural anticancer agent exerts cytotoxic effects on several tumors by targeting multiple pathways, including apoptosis. Difluoromethylornithine (DFMO), an irreversible inhibitor of the ornithine decarboxylase (ODC) enzyme, has shown promising inhibitory activities in many cancers leukemia decreasing biosynthesis intracellular polyamines. The present study aimed to investigate combinatorial TQ and DFMO human acute T lymphoblastic Jurkat cells determine underlying...
(-) Epicatechin (EP) is a naturally occurring antioxidant flavonoid found in some green plants. The current study was designed to evaluate the potential role of mechanisms hepatoprotective properties EP using carbon tetrachloride (CCl4)-induced acute liver injury model.Rats (n = 7 per group) were divided into five groups including control group, epicatechin group (20 mg·kg-1 body weight), CCl4 (1 mL-1 CCl4-EP treatment and CCl4-silymarin (SILY) group. levels enzymes hepatic malondialdehyde...
We report here a new class of compounds, quinoline derivatives, as potential inhibitors in vitro bovine serum albumin-methylglyoxal glycation. Among compounds 1-19, compound 14 was found to be the most active analog with IC50 282.98 ± 8.4 µM. Compounds 12 (IC50 = 661.78 8.7 µM) and 15 629.43 7.85 7 were also identified modest inhibitors, comparison standard inhibitor, rutin 294.50 1.5 µM). When evaluated for antioxidant activity through DPPH radical scavenging assay, 3 2.19 0.27 µM), 6 7.35...
Background: There is a high prevalence of diabetes mellitus type-2 (T2DM) and osteoporosis are problems worldwide. In this study, we evaluated the correlation between T2DM bone turnover in diabetic obese postmenopausal Saudi women.Subjects Methods: The present study included total 65 T2-DM women, (36 uncontrolled, 29 controlled) .The following serum biochemical parameters were [fasting blood glucose (FBG),total calcium (Ca), phosphorus (Pi), parathyroid hormone (PTH), 1,25-(OH)2Vitamin D3...
Background: The current trend globally is the utilization of natural products as therapeutic agents given its minimum side effects.
 leaves Stevia contain several active ingredient compounds such rebaudioside. extract have been used for many
 purposes. Active oxygen radicals can induce base modifications, DNA breakage, and intracellular protein crosslink's. This study was
 done to evaluate potential stevia antibacterial antioxidants actions.
 Materials methods:...
Chitinase enzymes have a various application in the field of environmental, biotechnology and medical aspects. This study aimed to production chitinolytic from different species bacteria.Bacterial isolation habitats was carried out on agar medium containing chitin as carbon nitrogen sources. The obtained bacteria (20) were characterized screened again broth medium.Out 20 bacterial isolate, 2 new isolates, belonged Streptomyces laurentii SN5 Cellulosimicrobium funkei SN20, most active...
Autism Spectrum Disorder (ASD) is a multifaceted neurodevelopmental condition characterized by multiple psychological and physiological impairments in young children. According to the recent reports, 1 out of every 58 newly-born children suffering from autism. The aetiology disorder complex poorly understood, hindering adaptation targeted effective therapies. There are no well- established diagnostic biomarkers for Hence analysis symptoms pediatricians plays critical role early...
Multidrug resistance (MDR) is a major reason for the failure of acute myeloid leukemia (AML) therapy. Agents that reverse MDR and sensitize AML cells to chemotherapy are great clinical significance. The present study developed Adriamycin (Adr)‑resistant cell lines, namely K562/Adr200 K562/Adr500, which exhibited MDR. upregulation ATP‑binding cassette subfamily B member 1 (ABCB1) was confirmed as mechanism by transcription‑quantitative polymerase chain reaction western blot analyses....