A5004589445- Epigenetics and DNA Methylation
- Cancer Genomics and Diagnostics
- Computational Drug Discovery Methods
- Alzheimer's disease research and treatments
- Cholinesterase and Neurodegenerative Diseases
- Genetic factors in colorectal cancer
- Blood groups and transfusion
- Reproductive Biology and Fertility
- Platelet Disorders and Treatments
- Sperm and Testicular Function
- SARS-CoV-2 and COVID-19 Research
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- MicroRNA in disease regulation
- Prenatal Screening and Diagnostics
- Cancer-related gene regulation
- Reproductive Health and Technologies
- Synthesis and biological activity
- Natural Antidiabetic Agents Studies
- Blood Coagulation and Thrombosis Mechanisms
- Kruppel-like factors research
- Hemophilia Treatment and Research
- Osteoarthritis Treatment and Mechanisms
- Genomic variations and chromosomal abnormalities
- Cancer-related molecular mechanisms research
King Abdulaziz University
2015-2024
Center for Genomic Science
2018-2020
Theodor Bilharz Research Institute
2020
King Abdulaziz City for Science and Technology
2013-2018
Prince Sattam Bin Abdulaziz University
2014
Gazi University
2000
Royal Hallamshire Hospital
1994-2000
Aarhus University Hospital
2000
University of Sheffield
2000
Leukocytes contribute directly and indirectly to reactive oxygen species (ROS) production. Although leukocytospermia is defined as the presence of ≥1 × 106 white blood cells/mL (WBC/mL) in a semen sample, less than 1×106 WBC/mL (low-level leukocytospermia) can still produce detectable amount ROS, impairing sperm function lowering chances pregnancy. Our objective was assess effect low-level on quality, ROS levels, DNA damage infertile men. Semen samples were examined from 472 patients divided...
A routine semen analysis is a first step in the laboratory evaluation of infertile male. In addition, other tests such as measurement reactive oxygen species can provide additional information regarding etiology male infertility. The objective this study was to investigate association parameters with (ROS) two groups: healthy donors unproven and proven fertility men. we sought establish an ROS cutoff value seminal plasma at which patient may be predicted infertile.Seminal ejaculates from 318...
Hepatocellular carcinoma (HCC) accounts for major cancer-related deaths despite current advanced therapies. Treatment and prognosis of HCC is better in patients with preserved liver function. Many natural products including ajwa dates (Phoenix dactylifera L.), are claimed to have hepatoprotective inhibitory effects, but most lack scientific validation. To prove our hypothesis, we attempted evaluate the other beneficial properties aqueous extract (ADE) a rat model diethylnitrosamine (DEN)...
Phoenix dactylifera L (Date palm) is a native plant of the Kingdom Saudi Arabia (KSA) and other Middle Eastern countries. Ajwa date has been described in traditional alternative medicine to provide several health benefits including anticholesteremic, antioxidant, hepatoprotective anticancer effects, but most remains be scientifically validated. Herein, we evaluated effects Methanolic Extract Date (MEAD) on human breast adenocarcinoma (MCF7) cells vitro.MCF7 were treated with various...
Density gradient is the preferred technique for sperm processing ART. However, no study has examined quality using different media simultaneously and under identical conditions. Therefore, we evaluated semen following preparation by three commonly used commercially available density in a well-designed controlled trial. We obtained samples from 20 healthy volunteers. Percent motility, total motile (TMS), % recovery DNA damage were assessed before after separation media-PureCeption, ISolate...
The effect of paternal age on semen quality is controversial. In this retrospective study, the aim was to investigate effects advancing sperm parameters including reactive oxygen species (ROS), total antioxidant capacity (TAC) and DNA damage in infertile men. We also examined whether >40 y associated with higher risk damage. A 472 men presenting for infertility were divided into 4 groups: group A: patients ≤ 30 y; B: 31- 40 y, C: D: y. following tests performed - analysis according WHO 2010...
Phthalates are a class of high volume production chemicals used as plasticizers for household and industrial use. Several members this chemical family have endocrine disrupting activity. Owing to ubiquitous environmental distribution exposure human population at all stages life, phthalate contamination is continuous global public health problem. Clinical experimental studies indicated that several phthalates associated with adverse effects on development function animal systems especially...
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a naphthoquinone derivative from the roots of plant Plumbago zeylanica and belongs to one largest diverse groups metabolites. The anticancer antiproliferative activities plumbagin have been observed in animal models as well cell cultures. exerts inhibitory effects on multiple cancer-signaling proteins, however, binding mode molecular interactions not yet elucidated for most these protein targets. present study first attempt provide...
Abstract In continuation of our previous studies, we developed polymeric epigallocatechin 3-gallate (EGCG)-loaded nanoparticles (NPs) coupled with folic acid (FA), able to dually bind the human folate receptor alpha (FOLR1), and prostate-specific membrane antigen (PSMA + ) in prostate cancer (PCa) model. After a preliminary computational molecular recognition NP′ ligand binding on FOLR1 active site, synthesized biocompatible block-copolymer PLGA–PEG–FA prepare EGCG-targeted NPs (EGCG-T-NPs)....
Exposure to toxic industrial chemicals that have capacity disrupt the endocrine system, also known as disrupting (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among most common environmental contaminants possessing disruption properties present plastics, epoxy resins, detergents other commercial products of personal use. metabolite...
Reactive oxygen species (ROS) plays a major role in the pathology of male infertility. It is an independent biomarker sperm function. Seminal plasma natural reservoir antioxidants responsible for nourishment, protection, capacitation, and motility within female reproductive tract resulting successful fertilization implantation embryo. A comparative proteomic analysis seminal proteins from fertile men infertile with varying levels ROS was carried out to identify signature involved...
Biobanks and biospecimen collections are becoming a primary means of delivering personalized diagnostics tailoring individualized therapeutics. This shift towards precision medicine (PM) requires interactions among variety stakeholders, including the public, patients, healthcare providers, government, donors. Very few studies have investigated role students in biobanking donations. The main aims this study were (1) to evaluate knowledge senior about biobanks (2) assess students' willingness...
Multidrug-resistance due to "β lactamases having the expanded spectrum" (ESBLs) in members of Enterobacteriaceae is a matter continued clinical concern. CTX-M among most common ESBLs family. In present study, nanoformulation cefotaxime was prepared using gold nanoparticles combat drug-resistance ESBL producing strains. Here, two CTX-M-15 positive resistant bacterial strains (i.e., one Escherichia coli and Klebsiella pneumoniae strain) were used for testing efficacy "cefotaxime loaded...
Aim: To evaluate the expression pattern of matrix metalloproteinases (MMPs); MMP-2, MMP-7 and MMP-9 in colorectal cancer (CRC) determine its prognostic potential. Patients & methods: CRC samples 127 patients were studied. Protein expressions -7 -9 analyzed by immunohistochemistry association with clinicopathological variables was statistically analyzed. Results: Overexpressions MMP-2 correlated poor outcome as evaluated univariate Kaplan–Meier for disease-free survival (p = 0.04, p 0.0001)...
Her2/neu is an oncogene that plays important role in the pathogenesis of many cancer types. In bladder carcinoma (BC), clinical significance status remains under-investigated and poorly linked to patients' clinic-pathological features survival status. Thus, current study was conducted assess a cohort Saudi Arabia, explore its prognostic value BC. A total 160 consent patients transitional cell (TCC) were arranged on tissue microarray (TMA) stained by immunohistochemistry (IHC) bright-field...
Angiogenesis plays a critical role in tumorigenesis as it provides the necessary blood supply to newly grown solid tumor. It helps maintain tumor microenvironment, promotes development, progression, and metastasis. The vascular epithelial growth factor (VEGF), interacting with tyrosine kinase receptor VEGFR-2 on endothelial cells, exerts its proangiogenic activity. Hence, targeting signaling is considered promising strategy inhibit angiogenesis thus cancer treatment. This study aims identify...