A5017505923- Hemoglobinopathies and Related Disorders
- Iron Metabolism and Disorders
- COVID-19 Clinical Research Studies
- Blood groups and transfusion
- T-cell and Retrovirus Studies
- Atherosclerosis and Cardiovascular Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Effects and risks of endocrine disrupting chemicals
- Platelet Disorders and Treatments
- SARS-CoV-2 and COVID-19 Research
- Alzheimer's disease research and treatments
- Hepatitis C virus research
- Cancer Genomics and Diagnostics
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Cholinesterase and Neurodegenerative Diseases
- Erythrocyte Function and Pathophysiology
- Folate and B Vitamins Research
- Galectins and Cancer Biology
- Computational Drug Discovery Methods
- Liver Disease Diagnosis and Treatment
- Vitamin C and Antioxidants Research
- Peroxisome Proliferator-Activated Receptors
- Inflammasome and immune disorders
- Bioactive Compounds and Antitumor Agents
- Brain Metastases and Treatment
King Abdulaziz University
2015-2024
King Abdulaziz Hospital
2016
King Abdul Aziz University Hospital
2011
Adult T-cell Leukemia (ATL) is a disease with no known cure. The manifests itself as an aggressive proliferation of CD4+ cells the human Lymphotropic virus type 1 (HTLV-1). leukemogenesis mainly attributed to viral oncoprotein. Tax activates Nuclear Factor kappa B (NF-κB) which stimulates activity and expression matrix metalloproteinase-9 (MMP-9). objective this study was investigate efficacy specific nutrient synergy (SNS) on proliferation, expression, NF-κB levels well MMP-9 both at...
Phthalates are a class of high volume production chemicals used as plasticizers for household and industrial use. Several members this chemical family have endocrine disrupting activity. Owing to ubiquitous environmental distribution exposure human population at all stages life, phthalate contamination is continuous global public health problem. Clinical experimental studies indicated that several phthalates associated with adverse effects on development function animal systems especially...
Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) is a naphthoquinone derivative from the roots of plant Plumbago zeylanica and belongs to one largest diverse groups metabolites. The anticancer antiproliferative activities plumbagin have been observed in animal models as well cell cultures. exerts inhibitory effects on multiple cancer-signaling proteins, however, binding mode molecular interactions not yet elucidated for most these protein targets. present study first attempt provide...
Exposure to toxic industrial chemicals that have capacity disrupt the endocrine system, also known as disrupting (EDCs), has been increasingly associated with reproductive problems in human population. Bisphenol A (BPA; 4,4'-(propane-2,2-diyl)diphenol) and 4-tert-octylphenol (OP; 4-(1,1,3,3-tetramethylbutyl)phenol) are among most common environmental contaminants possessing disruption properties present plastics, epoxy resins, detergents other commercial products of personal use. metabolite...
The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer results led to entry into Phase I/II clinical trials. Despite such importance, the exact binding mechanism molecular interactions with human are not available. current study investigated mode isoforms...
BACKGROUND Middle East respiratory syndrome‐coronavirus (MERS‐CoV) is a novel zoonotic pathogen. Although the potential for MERS‐CoV transmission through blood transfusion not clear, was recognized as pathogen of concern safety supply especially after its detection in whole blood, serum, and plasma infected individuals. Here we investigated efficacy amotosalen ultraviolet A light (UVA) to inactivate fresh‐frozen (FFP). STUDY DESIGN AND METHODS Pooled FFP units were spiked with recent...
Health consciousness has increased the desire of people around world to consume functional foods. Omega-3 essential fatty acids are one among these beneficial and important health supplements without which a general predisposition degenerative stress related disorders can occur. Saudi Arabia shown an alarming increase in obesity (Al-Nozha et al., 2005), diabetes (Alqurashi 2011), cardiovascular disease 2004) last few decades mainly due nutritional transitions lifestyle alterations (Amuna...
SUMMARY Objective This study aimed to assess the efficacy of INTERCEPT™ Blood System [amotosalen/ultraviolet A (UVA) light] reduce risk Middle East respiratory syndrome‐Coronavirus (MERS‐CoV) transmission by human platelet concentrates. Background Since 2012, more than 2425 MERS‐CoV cases have been reported in 27 countries. The infection causes acute disease, which was responsible for 838 deaths these countries, mainly Saudi Arabia. Viral genomic RNA detected whole blood, serum and plasma...
Meningioma tumors arise in arachnoid membranes, and are the most reported central nervous system (CNS) worldwide. Up to 20% of grade I meningioma reoccur currently predictive cancer stem cells (CSCs) markers for aggressive drug resistant meningiomas scarce. tissues primary cell lines were investigated using whole transcriptome microarray analysis, immunofluorescence staining CSCs (including CD133, Sox2, Nestin, Frizzled 9), treatment with cisplatin or etoposide. Unsupervised hierarchical...
The nonstructural protein 3 (NS3) of hepatitis C virus (HCV) helicase is believed to be essential for viral replication and has become an attractive target the development antiviral drugs. study useful elucidating its involvement in positive sense single-stranded RNA serve as templates design novel In recent years, several models have been proposed on conformational change leading movement unwinding. Some compounds recently reported inhibit these include small molecules, aptamers antibodies....
Abstract Interleukin‐10 (IL‐10) is an anti inflammatory cytokine involved in the ongoing coronary inflammation and related patho‐physiological processes. The piece of work presented herein aimed at investigating possible association polymorphisms IL‐10 promoter with Saudi cardiovascular disease (CVD) patients. study included 80 confirmed CVD patients diabetes 75 healthy control individuals both men women. Concentration serum samples were measured by ELISA method. For single nucleotide...
Background The current standard care therapy for hepatitis C virus (HCV) infection consists of two regimes, namely interferon-based and interferon-free treatments. treatment through the combination ribavirin pegylated interferon is expensive, only mildly effective, associated with severe side effects. In 2011, direct-acting antiviral (DAA) drugs, boceprevir telaprevir, were licensed that have shown enhanced sustained virologic response (SVR) in phase III clinical trial, however, these...
Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol molecule from green tea and known to exhibit antioxidative as well tumor suppressing activity. In order examine EGCG invasion activity against adult T-cell leukemia (ATL), two HTLV-1 positive cells (HuT-102 C91-PL) were treated with non-cytotoxic concentrations of for 2 4 days. Proliferation was significantly inhibited by 100 <TEX>${\mu}M$</TEX> at days, low cell lysis or cytotoxicity. oncoprotein (Tax) expression in HuT-102...