A5037262248- Hepatitis C virus research
- Liver Disease Diagnosis and Treatment
- Hepatitis B Virus Studies
- Bacteriophages and microbial interactions
- Endoplasmic Reticulum Stress and Disease
- Herpesvirus Infections and Treatments
- Computational Drug Discovery Methods
- Monoclonal and Polyclonal Antibodies Research
- Viral gastroenteritis research and epidemiology
- vaccines and immunoinformatics approaches
- SARS-CoV-2 and COVID-19 Research
- Cytomegalovirus and herpesvirus research
- Mosquito-borne diseases and control
- Diabetes and associated disorders
- Viral Infections and Vectors
- Drug Transport and Resistance Mechanisms
- RNA and protein synthesis mechanisms
- Viral Infections and Immunology Research
- Organometallic Compounds Synthesis and Characterization
- Chronic Lymphocytic Leukemia Research
- Systemic Lupus Erythematosus Research
- RNA Interference and Gene Delivery
- Toxoplasma gondii Research Studies
- RNA modifications and cancer
- Cervical Cancer and HPV Research
King Abdulaziz University
2016-2025
Bridge University
2021
Khulna University
2021
Ajman University
2021
Islamic University
2021
Zhejiang Sci-Tech University
2021
University of Science and Technology
2021
King Abdul Aziz University Hospital
2015-2019
University of Jeddah
2015-2019
University of Florida
2016-2017
Several viral transcriptional activators have been shown to interact with the basal transcription factor TATA-binding protein (TBP). These associations implicated in facilitating assembly of preinitiation complex. We report here that hepatitis B virus X (pX) specifically binds TBP vitro. While truncations highly conserved carboxyl terminus abolished this binding, amino-terminal deletions had no effect. Deletion analysis suggests a domain consisting 71 aa carboxyl-terminal region is necessary...
Nonalcoholic steatohepatitis (NASH) is characterized by steatosis, inflammation, and oxidative stress. To investigate whether the transcription factor CCAAT/Enhancer binding protein (C/EBPbeta) involved in development of NASH, C57BL/6J wild-type (WT) or C/EBPbeta knockout (C/EBPbeta-/-) mice were fed either a methionine choline deficient (MCD) diet standard chow. These WT MCD for 4 weeks showed 2- to 3-fold increase liver messenger RNA protein, along with increased expression lipogenic genes...
Minichromosome maintenance complex component 7 (MCM7) belongs to the minichromosome family that is important for initiation of eukaryotic DNA replication. Overexpression MCM7 protein relative cellular proliferation and responsible aggressive malignancy in various cancers. Mechanistically, inhibition significantly reduces associated with cancer. To date, no effective small molecular candidate has been identified can block progression cancer induced by protein. Therefore, study designed...
Middle East respiratory syndrome coronavirus (MERS-CoV) is a highly infectious zoonotic virus first reported into the human population in September 2012 on Arabian Peninsula. The causes severe and often lethal illness humans with an unusually high fatality rate. N-terminal domain (NTD) of receptor-binding S1 subunit spike (S) proteins can recognize variety host protein mediates entry cells. Blocking by targeting S1-NTD facilitate development effective antiviral drug candidates against...
The 78-kDa glucose-regulated protein (GRP78) is a major endoplasmic reticulum (ER) that can form stable associations with variety of proteins retained in the ER because underglycosylation or other conformational changes. In this study, we provide evidence at transcriptional level conformationally abnormal protein, an altered herpes simplex virus type 1 envelope mammalian cell line, transactivates grp78 promoter. contrast, normal viral glycoprotein does not elevate promoter activity. Using...
Activation of cellular kinases and transcription factors mediates the early phase response to chemically or biologically induced stress. In present study we investigated oxidant/antioxidant balance in Huh-7 cells expressing HCV (hepatitis C virus) subgenomic replicon, observed a 5-fold increase oxidative stress during replication. We used MnSOD (manganese-superoxide dismutase) as an indicator antioxidant response, found that its activity, protein levels promoter activity were significantly...
Human hepatitis B virus genome encodes a protein, termed HBx, that is widely recognized as transcriptional transactivator. While HBx does not directly bind cis-acting control elements, it has been shown to associate with cellular proteins DNA. Because transactivated large number of viral/cellular we looked for its targets within the components basal machinery. This search led identification interactions TFIIH. Here, show interacts yeast and mammalian TFIIH complexes both in vitro vivo. These...
Colorectal cancer (CRC) is the second most common cause of death worldwide, affecting approximately 1.9 million individuals in 2020. Therapeutics disease are not yet available and discovering a novel anticancer drug candidate against an urgent need. Thymidylate synthase (TS) important enzyme prime precursor for DNA biosynthesis that catalyzes methylation deoxyuridine monophosphate (dUMP) to deoxythymidine (dTMP) has emerged as target disease. Elevated expression TS proliferating cells...
Carbapenem-resistant