A5075296153- Tea Polyphenols and Effects
- Tannin, Tannase and Anticancer Activities
- Protease and Inhibitor Mechanisms
- Antioxidant Activity and Oxidative Stress
- Vitamin C and Antioxidants Research
- Cancer, Lipids, and Metabolism
- Cancer Research and Treatments
- Cancer-related Molecular Pathways
- Genetics, Aging, and Longevity in Model Organisms
- COVID-19 Clinical Research Studies
- Phytochemicals and Antioxidant Activities
- Curcumin's Biomedical Applications
- Cancer, Stress, Anesthesia, and Immune Response
- Vitamin D Research Studies
- Peptidase Inhibition and Analysis
- SARS-CoV-2 and COVID-19 Research
- Heat shock proteins research
- Antimicrobial Peptides and Activities
- Nanoplatforms for cancer theranostics
- Retinoids in leukemia and cellular processes
- T-cell and Retrovirus Studies
- Protein Hydrolysis and Bioactive Peptides
- Vector-borne infectious diseases
- Atherosclerosis and Cardiovascular Diseases
- Drug-Induced Hepatotoxicity and Protection
Rath Research Institute
2015-2024
Optica
2022
Cellular Research (United States)
2010
Palo Alto Institute
1992-1998
Stanford University
1991
Abstract The strain SARS-CoV-2, newly emerged in late 2019, has been identified as the cause of COVID-19 and pandemic declared by WHO early 2020. Although lipids have shown to possess antiviral efficacy, little is currently known about lipid compounds with anti-SARS-CoV-2 binding entry properties. To address this issue, we screened, overall, 17 polyunsaturated fatty acids, monounsaturated acids saturated wells lipid-soluble vitamins. In performing target-based ligand screening utilizing...
Adult T-cell Leukemia (ATL) is a disease with no known cure. The manifests itself as an aggressive proliferation of CD4+ cells the human Lymphotropic virus type 1 (HTLV-1). leukemogenesis mainly attributed to viral oncoprotein. Tax activates Nuclear Factor kappa B (NF-κB) which stimulates activity and expression matrix metalloproteinase-9 (MMP-9). objective this study was investigate efficacy specific nutrient synergy (SNS) on proliferation, expression, NF-κB levels well MMP-9 both at...
In the pursuit of suitable and effective solutions to SARS-CoV-2 infection, we investigated efficacy several phenolic compounds in controlling key cellular mechanisms involved its infectivity. The way virus infects cell is a complex process comprises four main stages: attachment cognate receptor, entry, replication egress. Since, this multi-part process, it creates many opportunities develop interventions. Targeting binding host receptor order prevent entry has been particular interest....
Superoxide dismutases (SOD) play a major role in the intracellular defense against oxygen radical damage to aerobic cells. In eucaryotes, cytoplasmic form of enzyme is 32-kDa dimer containing two copper and zinc atoms (CuZn SOD) that catalyzes dismutation superoxide anion (O2-) H2O2 O2. Superoxide-mediated has been implicated number biological processes, including aging cancer; however, it not certain whether endogenously elevated levels SOD will reduce pathological events resulting from...
Superoxide dismutases (SOD) play a major role in the intracellular defense against oxygen radical damage to aerobic cells. In eucaryotes, cytoplasmic form of enzyme is 32-kDa dimer containing two copper and zinc atoms (CuZn SOD) that catalyzes dismutation superoxide anion (O2-) H2O2 O2. Superoxide-mediated has been implicated number biological processes, including aging cancer; however, it not certain whether endogenously elevated levels SOD will reduce pathological events resulting from...
Abstract Epigallocatechin gallate (EGCG), a main anticancer component in green tea, has poor bioavailability rats and humans due to oxidation, metabolism its efflux. It was hypothesized that nutrients address these problems might result increased bioavailability. Plasma concentrations of EGCG at various time intervals were determined calculate compare the pharmacokinetic parameters after oral administration tea extract (GTE) or GTE as nutrient mixture (E) E + quercetin (Q)/red onions. In rat...
Background: Angiotensin-converting enzyme II or ACE2 is an integral membrane protein present on many types of cells, including vascular endothelial cells and lung alveolar epithelial cells. This receptor serves as the entry point for SARS-coronaviruses (SARS-CoVs), a novel coronavirus 2019-nCoV. Limited availability these receptors can thwart cellular this virus. Methods: We tested effects ascorbic acid (vitamin C) expression at RNA levels in human small microvascular In addition, we...
The limited ability of current treatments to control metastasis and the proposed antitumor properties specific nutrients prompted us examine effect a formulation (nutrient supplement [NS]) lysine, proline, arginine, ascorbic acid, green tea extract in vivo on development N-methyl-N-nitrosourea (MNU)-induced mammary tumors rats. A single intraperitoneal dose MNU was injected into each 20 female Sprague–Dawley rats (aged 50 days) induce tumors. Two weeks after treatment, time by which animals...
We examined the effect of cellular aging on adult mortality and hsp70 gene expression in Drosophila melanogaster under thermal stress. The results showed that flies exposed to 37 degrees C for various time intervals had reduced survival rate with age. level mRNA increases up 23-28 days age, but then declines as they get older. When are shifted 25 after 30 min heat stress, time-dependent decrease levels occurs more rapidly young than old ones. present during this recovery period is translated...
Despite vaccine availability, the global spread of COVID-19 continues, largely facilitated by emerging SARS-CoV-2 mutations. Our earlier research documented that a specific combination plant-derived compounds can inhibit binding to its ACE2 receptor and controlling key cellular mechanisms viral infectivity. In this study, we evaluated efficacy defined mixture plant extracts micronutrients against original Alpha, Beta, Gamma, Delta, Kappa, Mu variants. The composition containing vitamin C,...
The authors investigated the effect of a nutrient mixture (NM) on lung metastasis by B16F0 melanoma cells in C57BL/6 female mice. Mice were divided into equal groups (1 to 6) and injected via tail vein with (groups 1 4), B16FO pretreated NM (group 5), or saline 6). Groups 1, 3, 4, 5, 6 fed control diet group 2 0.5% supplemented diet. 3 4 received intraperitoneally (IP) intravenously (IV), respectively. Two weeks later, pulmonary metastatic colonies counted. Pulmonary colonization was reduced...
Aims: Little is known about the effects of phytochemicals against Borrelia sp.causing Lyme disease.Current therapeutic approach to this disease limited antibiotics.This study examined anti-borreliae efficacy several plantderived compounds and micronutrients.Methods Results: We tested 15 micronutrients three morphological forms burgdoferi garinii: spirochetes, latent rounded biofilm.The results showed that most potent substances spirochete B. burgdorferi garinii were cis-2-decenoic acid,...
Epigallocatechin-3-gallate (EGCG) is the most abundant polyphenol molecule from green tea and known to exhibit antioxidative as well tumor suppressing activity. In order examine EGCG invasion activity against adult T-cell leukemia (ATL), two HTLV-1 positive cells (HuT-102 C91-PL) were treated with non-cytotoxic concentrations of for 2 4 days. Proliferation was significantly inhibited by 100 <TEX>${\mu}M$</TEX> at days, low cell lysis or cytotoxicity. oncoprotein (Tax) expression in HuT-102...
Influenza, one of the oldest and most common infections, poses a serious health problem causing significant morbidity mortality, imposing substantial economic costs. The efficacy current drugs is limited improved therapies are needed. A unique nutrient mixture (NM), containing ascorbic acid, green tea extract, lysine, proline, N-acetyl cysteine, selenium among other micronutrients, has been shown to exert anti-carcinogenic anti-atherogenic activity both in vitro vivo. Many constituents NM...