A5009816604- Natural Antidiabetic Agents Studies
- Advanced Glycation End Products research
- Legume Nitrogen Fixing Symbiosis
- Biochemical effects in animals
- Drug-Induced Hepatotoxicity and Protection
- Diatoms and Algae Research
- Effects and risks of endocrine disrupting chemicals
- Genomics and Phylogenetic Studies
- Protein Hydrolysis and Bioactive Peptides
- Plant Parasitism and Resistance
- Phytochemical and Pharmacological Studies
- Antioxidant Activity and Oxidative Stress
- Fatty Acid Research and Health
- Plant Reproductive Biology
- Heme Oxygenase-1 and Carbon Monoxide
- Toxic Organic Pollutants Impact
- Plant tissue culture and regeneration
- Phytochemicals and Antioxidant Activities
- Cardiac Ischemia and Reperfusion
- Seaweed-derived Bioactive Compounds
- Seed Germination and Physiology
- Plant-based Medicinal Research
- Computational Drug Discovery Methods
- Microbial Community Ecology and Physiology
- Hyperglycemia and glycemic control in critically ill and hospitalized patients
Taif University
2025
King Abdul Aziz University Hospital
2011-2024
King Abdulaziz University
2013-2022
University College London
2016-2022
University of Jeddah
2018-2021
King Fahd Medical City
2017-2020
Ain Shams University
2019
The antidiabetic activity of two low doses Moringa seed powder (50 and 100 mg/kg body weight, in the diet) on streptozotocin (STZ) induced diabetes male rats was investigated. Forty were divided into four groups. diabetic positive control (STZ treated) group showed increased lipid peroxide, IL-6, decreased antioxidant enzyme serum kidney tissue homogenate compared with that negative group. Immunoglobulins (IgA, IgG), fasting blood sugar, glycosylated hemoglobin<mml:math...
Abstract The Leguminosae has emerged as a model for studying angiosperm plastome evolution because of its striking diversity structural rearrangements and sequence variation. However, most what is known about legume plastomes comes from few genera representing subset lineages in subfamily Papilionoideae. We investigate Mimosoideae based on two newly sequenced ( Inga Leucaena ) recently published Acacia Prosopis discuss the results context other rosid plastid genomes. Mimosoid have typical...
SARS coronavirus (COVID-19) is a real health challenge of the 21st century for scientists, workers, politicians, and all humans that has severe cause epidemic worldwide. The virus exerts its pathogenic activity through by mechanism gains entry via spike proteins (S) Angiotensin-Converting Enzyme 2 (ACE2) receptor on host cells. present work an effort computational target to block residual binding protein (RBP) (S), probiotics namely Plantaricin BN, JLA-9, W, D along with RNA-dependent RNA...
Abstract To date, publicly available plastid genomes of legumes have for the most part been limited to subfamily Papilionoideae. Here we report 13 new spanning all three subfamilies. The representing Caesalpinioideae and Mimosoideae are highly conserved in gene content order, similar ancestral angiosperm genome organization. Genomes within Papilionoideae, however, reduced sizes due deletions nine intergenic spacers primarily large single copy region. Our study also indicates that rps16 has...
Cisplatin (CP) is known as a potent anti-cancer drug. The most therapeutic adverse effect of CP induced hepatotoxicity. In the present study, protective thymoquinone (TQ) on CP-induced hepatotoxicity was studied. Wistar rats were divided into three groups (15 each). Group 1 served control group. 2 injected ip with single dose (12 mg/kg b.w, i.p.). 3 orally pre-treated TQ (500 mg. kg−1. day−1) for one month, then animals i.p 12 mg.kg−1. beneficial effects its antioxidant/anti-inflammatory...
Human exposure to phthalates is ubiquitous and has received considerable attention due their association with adverse health outcomes, including type 2 diabetes mellitus (T2DM). Nevertheless, earlier studies that link phthalate T2DM yielded ambiguous results. Furthermore, associate oxidative stress then are scant. In this diabetic case-control study, urine samples collected from 101 individuals aged 28-68 years Jeddah, Saudi Arabia, were analyzed determine 20 metabolites (PhMs) seven...
Diabetes mellitus type 1 is an autoimmune disorder caused by lymphocytic infiltration and beta cells destruction. Curcumin has been identified as a potent inducer of heme-oxygenase-1 (HO-1), redoxsensitive inducible protein that provides protection against various forms stress. A novel water soluble curcumin derivative (NCD) developed to overcome low in vivo bioavailability curcumin. The aim the present work evaluate anti diabetic effects "NCD" its on diabetes-induced ROS generation lipid...
Information regarding transcriptome and metabolome has significantly contributed to identifying potential therapeutic targets for the management of a variety cancers. Obesity profound effects on both cancer cell that can affect outcome therapy. The information obesity breast (BC) transcriptome, its integration identify novel pathways related disease progression are still elusive. We assessed whole blood serum metabolome, as circulating metabolites, obese BC patients compared them with...
Zingiber officinale Roscoe, one of the most widely used spices, has been reported to have anti-obesity and anti-diabetes effects. In present study, we investigated effects 6-shogaol, a bioactive compound in ginger, on adipogenic process 3T3-L1 preadipocytes. The anti-adipogenic 6-shogaol was significantly higher than more 6-gingerol, another major ginger constituent. We observed that inhibited expression two master regulators adipogenesis, PPARγ C/EBPα, also stimulated lipolysis mature...
Diatoms are very efficient in their use of available nutrients. Changes nutrient availability influence the metabolism and composition cell constituents. Since diatoms valuable candidates to search for oil producing algae, measurements diatom-produced compounds can be useful biotechnology. In order explore diversity lipophilic produced by diatoms, we describe results from an analysis 13 diatom strains. With help a lipidomics platform, which combines UPLC separation with high resolution/high...
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in patients with diabetes mellitus (DM). To identify most effective treatment for CVD, it paramount to understand mechanism behind cardioprotective therapies. Although metformin has been shown reduce CVD Type-2 DM clinical trials, underlying remains unexplored. CD34+ cell-based therapies offer a new approach CVD. The aim this study was investigate effect on angiogenic properties cells under conditions mimicking...
This study investigated the in vitro antioxidant, proapoptotic and anti-proliferative activity of phycocyanin extracted from Ulva lactuca (Chlorophyta) algae extract loaded on albumin nanoparticle (ULANP). The characterization ULANP profile was done by using FTIR its cytotoxicity MTT assay against HepG2 MCF7 cell lines. markers caspase 8 & 9 were measured. Analysis showed characteristic band (2100 cm-1 ~3700 cm-1) that is indicated primarily -COO, -CO conjugated double bond. These bonds...
Abstract Human umbilical vein endothelial cell (HUVEC)-based gene expression studies performed under hypoxia and/or hyperglycemia show huge potential for modeling response in cardiovascular disease and diabetes. However, such require reference genes that are stable across the whole range of experimental conditions. These have not been comprehensively defined to date. We applied human genome-wide microarrays quantitative real-time PCR (qRT-PCR) on RNA obtained from primary HUVEC cultures were...
This study was carried out to the proteome of date palm under salinity and drought stress conditions possibly identify proteins involved in tolerance. For this purpose, three-month-old seedlings cultivar “Sagie” were subjected (27.5 g/L polyethylene glycol 6000) (16 NaCl) for one month. DIGE analysis protein extracts identified 47 differentially expressed leaves salt- drought-treated seedlings. Mass spectrometric 12 proteins; three them significantly changed both salt stress, while other...
Nicotine is a major pharmacologically active and addictive component of tobacco smoke, which regarded to be primary risk factor in the development cardiovascular pulmonary diseases. Epicatechin one most potent antioxidants present human diet. Particularly high levels this compound are found tea, apples chocolate. It has been reported that tea extracts and/or its constituents have antibacterial, antiviral, antioxidative, antitumor antimutagenic activities. Vitamin E lipid-soluble antioxidant...
Abstract Alkaloid accumulation in plants is activated response to stress, limited distribution and specific alkaloid repertoires are variable across taxa. Rauvolfioideae (Apocynaceae, Gentianales) represents a major center of structural expansion the monoterpenoid indole alkaloids (MIAs) yielding thousands unique molecules including highly valuable chemotherapeutics. The paucity genome-level data for Apocynaceae precludes deeper understanding MIA pathway evolution hindering elucidation...
Date palm cultivars differently tolerate salinity and drought stress. This study was carried out to the response of date severe based on leaf proteome analysis. Eighteen-month-old plants were subjected salt (48 g/L NaCl) (82.5 PEG or no irrigation) conditions for one month. Using a protein 2D electrophoresis method, 55 spots analyzed using mass spectrometry. ATP synthase CF1 alpha chains significantly upregulated under all three stress conditions. Changes in abundance RubisCO activase...