A5020229477- Air Quality and Health Impacts
- Climate Change and Health Impacts
- Energy and Environment Impacts
- Nanoparticles: synthesis and applications
- Chemotherapy-induced organ toxicity mitigation
- Smoking Behavior and Cessation
- Air Quality Monitoring and Forecasting
- Heme Oxygenase-1 and Carbon Monoxide
- Inhalation and Respiratory Drug Delivery
- Pharmacological Effects and Toxicity Studies
- Acute Kidney Injury Research
- Asthma and respiratory diseases
- Genomics, phytochemicals, and oxidative stress
- Advanced Glycation End Products research
- Vehicle emissions and performance
- Pesticide Exposure and Toxicity
- Chronic Obstructive Pulmonary Disease (COPD) Research
- Pediatric health and respiratory diseases
- Diet and metabolism studies
- Chronic Kidney Disease and Diabetes
- Ginger and Zingiberaceae research
- Curcumin's Biomedical Applications
- Pharmacology and Obesity Treatment
- Heavy Metal Exposure and Toxicity
- Hydrogen's biological and therapeutic effects
United Arab Emirates University
2016-2025
Zayed University
2020-2025
Al Ain University
2013-2018
Czech Academy of Sciences, Institute of Physiology
2012-2017
KU Leuven
2001-2011
Sultan Qaboos University
2006-2010
Vrije Universiteit Amsterdam
2005
Center for Vascular Biology Research
2005
Medical Research Council
2003
MRC Toxicology Unit
2002
Short-term exposure to cigarette smoke (CS) or lipopolysaccharide (LPS) leads acute lung inflammation through oxidant-antioxidant imbalance. We studied the response in mice exposed LPS during five consecutive days, as measured by superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) activities, well lipid peroxidation nitric oxide levels bronchoalveolar lavage fluid (BALF), homogenates, plasma. Control were ambient air. Exposure CS led a similar influx of alveolar...
Background — Pollution by particulates has been consistently associated with increased cardiovascular morbidity and mortality. However, the mechanisms responsible for these effects are not well-elucidated. Methods Results To assess to what extent how rapidly inhaled pollutant particles pass into systemic circulation, we measured, in 5 healthy volunteers, distribution of radioactivity after inhalation “Technegas,” an aerosol consisting mainly ultrafine 99m Technetium-labeled carbon (<100...
The mechanisms of particulate pollution-related cardiovascular morbidity and mortality are not well understood. We studied the passage radioactively labeled ultrafine particles after their intratracheal instillation. Hamsters received a single instillation 100 μ g albumin nanocolloid (nominal diameter ⩽ 80 nm) with Ci technetium-99m were killed 5, 15, 30, 60 min. In blood, radioactivity, expressed as percentage total body radioactivity per gram amounted to 2.88 ± 0.80%, 1.30 0.17%, 1.52...
Quantum dots (QDs) have numerous possible applications for in vivo imaging. However, toxicity data are scarce.To determine the acute of QDs with carboxyl surface coating (carboxyl-QDs) and amine (amine-QDs), we investigated inflammatory properties, tissue distribution, prothrombotic effects after intravenous injection.We performed particle characterization by transmission electron microscopy dynamic light scattering. Carboxyl-QDs amine-QDs were intravenously injected mice (1.44-3,600...
Particulate air pollution is associated with cardiovascular morbidity and mortality. To investigate this association, we studied the effect of ultrafine (60 nm) polystyrene particles on thrombus formation in a hamster model after intravenous intratracheal administration unmodified, carboxylate-polystyrene, or amine-polystyrene particles. Unmodified had no thrombosis up to 5 mg/kg. Carboxylate-polystyrene significantly inhibited at 500 100 μg/kg body weight but not 50 weight. In contrast,...
Pollution by particulates has consistently been associated with increased cardiovascular morbidity and mortality, but a plausible biological basis for this association is lacking.Diesel exhaust particles (DEPs) were instilled into the trachea of hamsters, blood platelet activation, experimental thrombosis, lung inflammation studied. Doses 5 to 500 micro g DEPs per animal induced neutrophil influx bronchoalveolar lavage fluid elevation protein histamine without lactate dehydrogenase release....
Inflammation and oxidative stress are known to be involved in the pathogenesis of chronic kidney disease humans, renal failure (CRF) rats. The aim this work was study role inflammation adenine-induced CRF effect thereon purported nephroprotective agent gum arabic (GA). Rats were divided into four groups treated for 4 weeks as follows: control, adenine feed (0.75%, w/w), GA drinking water (15%, w/v) adenine+GA, before. Urine, blood kidneys collected from rats at end treatment analysis...
Chronic kidney disease (CKD) is known to involve inflammation, oxidative stress and apoptosis. Here, we investigated the impact of curcumin (diferuloyl methane, a phenolic turmeric pigment), which has strong antioxidant, anti-inflammatory anti-apoptotic activities on structure function in rats with adenine-induced CKD. Rats were treated for 5 weeks adenine induce CKD-like renal damage combined three doses curcumin. Markers quantified plasma, urine, homogenates tissue. Curcumin was found...
Abstract: The use of amorphous silica (SiO 2 ) in biopharmaceutical and industrial fields can lead to human exposure by injection, skin penetration, ingestion, or inhalation. However, the vivo acute toxicity SiO nanoparticles (SiNPs) on multiple organs mechanisms underlying these effects are not well understood. Presently, we investigated (24 hours) intraperitoneally administered 50 nm SiNPs (0.25 mg/kg) systemic toxicity, oxidative stress, inflammation, DNA damage lung, heart, liver,...
BACKGROUND AND PURPOSE Acute exposure to particulate air pollution has been linked acute cardiopulmonary events, but the underlying mechanisms are uncertain. EXPERIMENTAL APPROACH We investigated (at 4 and 18 h) effects of diesel exhaust particles (DEP) on parameters in mice protective effect thymoquinone, a constituent Nigella sativa . Mice were given, intratracheally, either saline (control) or DEP (30 µg·per mouse). KEY RESULTS At h (but not after giving DEP, there was lung inflammation...
Epidemiological evidence indicates that patients with chronic kidney diseases have increased susceptibility to adverse outcomes related long-term exposure particulate air pollution. However, mechanisms underlying these effects are not fully understood.Presently, we assessed the effect of prolonged diesel exhaust particles (DEP) on renal failure induced by adenine (0.25% w/w in feed for 4 weeks), which is known involve inflammation and oxidative stress. DEP (0.5m/kg) was intratracheally...
Ultrasmall superparamagnetic iron oxide nanoparticles (USPIO) are being developed for several biomedical applications including drug delivery and imaging. However, little is known about their possible adverse effects on thrombosis cardiac oxidative DNA damage.Presently, we investigated the acute (1 h) effect of intravenously (i.v.) administered USPIO in mice (0.4, 2 10 μg/kg). Diesel exhaust particles (DEP; 400 μg/kg) were used as positive control.USPIO induced a prothrombotic pial...
Exposure to particulate matter ≤2.5 μm in diameter (PM2.5) is associated with adverse respiratory outcomes, including alterations lung morphology and function. These associations were reported even at concentrations lower than the current annual limit of PM2.5. Inhalation PM2.5, which diesel exhaust particles (DEPs) a major component, induces inflammation oxidative stress. α-Bisabolol (BIS) bioactive dietary phytochemical various pharmacological properties, anti-inflammatory antioxidant...
Background— Particulate air pollution is associated with cardiovascular diseases and myocardial infarction (MI). Methods Results— We investigated the relationship between airway inflammation thrombosis 24 hours after intratracheal (IT) instillation of diesel exhaust particles (DEP; 50 μg/hamster). Mild was induced in femoral vein by endothelial injury, consequences on thrombogenicity were studied via online video microscopy. Lung histamine analysis bronchoalveolar lavage (BAL) plasma...
Short-term increases in particulate air pollution are associated with increased incidence of cardiovascular events. Previously, we showed that intratracheally instilled diesel exhaust particles (DEPs) prothrombotic. Here, investigated the time course and mechanisms. At 1, 6, 24 hours after instillation 50 μg DEPs per hamster, mean size vivo-induced quantified venous thrombosis was by 480%, 770%, 460%, respectively. Platelets activation blood confirmed a shortened closure platelet function...