Nephrotoxicity is one of the limiting factors for using doxorubicin (Dox) as an anticancer chemotherapeutic. Here, we investigated possible protective effect coenzyme-Q10 (CoQ10) on Dox-induced nephrotoxicity and mechanisms involved. Two doses (10 100 mg/kg) CoQ10 were administered orally to rats 8 days, in presence or absence induced by a single intraperitoneal injection Dox (15 at day 4 experiment. Our results showed that low dose succeeded reversing control levels (e.g., blood urea...

Abstract Hyperglycemia is one of the ischemic neuronal damage triggers that exacerbate response to oxidative stress, inflammation, and apoptosis induced by cerebral ischemia/reperfusion (I/R) injury. Empagliflozin, a sodium–glucose cotransporter 2 (SGLT 2) inhibitor, was shown effectively reduce hyperglycemia glucotoxicity besides improving glycemic control in diabetics. Therefore, present study conducted investigate neuroprotective effect empagliflozin against I/R injury hyperglycemic rats....

Methotrexate (MTX) is a commonly used chemotherapeutic agent. Oxidative stress and inflammation have been proved in the development of MTX toxicity. Paeonol natural phenolic compound with various pharmacological activities including antioxidant anti-inflammatory properties. The aim present study was to evaluate protective effect paeonol against MTX-induced cardiac toxicity rats mechanisms that underlie this effect. (100 mg/kg) administered orally for 10 days. induced at end fifth day...

Methotrexate is an effective anticancer and immunosuppressive agent. However, nephrotoxicity one of the complications its use. On other hand, curcumin, a naturally occurring polyphenolic compound, reported to have antioxidant anti-inflammatory properties. Those two properties are likely prevent methotrexate-induced nephrotoxicity. The aim this study evaluate possible protective effect curcumin against delineate various mechanism(s) underlies in rats. Nephrotoxicity was induced Wistar rats by...

Hepatoprotective potential of peroxisome proliferator activator receptor (PPAR)- α and - γ agonists, fenofibrate (FEN), pioglitazone (PIO), respectively, against cyclophosphamide (CP)-induced toxicity has been investigated in rat. FEN PIO (150 10 mg/kg/day, resp.) were given orally for 4 weeks. In separate groups, CP mg/kg, i.p.) was injected as a single dose 5 days before the end experiment, with or without either PPAR agonist. induced hepatotoxicity, it caused histopathological...

Background: Insulin dependent diabetes mellitus is a chronic metabolic disease. Many drugs used in its treatment which have number of serious adverse effects. Natural agent as quercetin (QCT) has been suggested the alternative medicine for mellitus. Aim work: To evaluate effect QCT on histological changes occur islet Langerhans streptozotocin (STZ)-induced diabetic rats and possible mechanisms through produces protective effect. Materials methods: Fourty five male albino were divided into...

Diabetic retinopathy is the most prevalent microvascular consequences of diabetes mellitus that can result in vision loss. Nanotechnology has been widely used treatment ophthalmic diseases. Selenium a naturally occurring compound antioxidant and anti-inflammatory effects. This study aimed at comparing possible ameliorating effect selenium versus Nano-selenium on streptozotocin-induced diabetic rats. Sixty adult male albino-Wister rats were divided randomly into six groups; control,...

Gentamicin, an aminoglycoside antibiotic, is used for the treatment of serious Gram-negative infections. However, its usefulness limited by nephrotoxicity. Sildenafil, a selective phosphodiesterase-5 inhibitor, was reported to prevent or decrease tissue injury. The aim this study evaluate potential protective effects sildenafil on gentamicin-induced nephrotoxicity in rats. Male Wistar rats were injected with gentamicin (100 mg/kg/day, i.p.) 6 days and without sildenafil. Sildenafil...

Introduction: Diabetes mellitus is a global problem and several restoration approaches have been developed to induce beta (β) cells regeneration. Platelet rich plasma (PRP) an autogenous economical source of growth factors which nowadays used in the tissue repair. Aim: To test hypothesis that PRP could play role improvement structural changes occurred in endocrine pancreas experimentally- induced diabetic rats possible mechanisms through PRP its effects shed light on use such...

Inflammatory bowel disease is defined as chronic noninfectious inflammation of the gastrointestinal tract, including ulcerative colitis and Crohn's disease. Its incidence predominance have increased globally, with no effective agents for preventing its recurrence or treatment until now.The current study aimed to investigate possible role canagliflozin (CANA), a sodium-glucose co-transporter-2 inhibitor (SGLT-2), prevent treat acetic acid (AA)-induced in rat model.Colitis was induced male...

Abstract Objective. The aim of the current study was to assess protective outcome hemin, a heme oxygenase-1 (HO-1) inducer on L-arginine-induced acute pancreatitis in rats. Acute (AP) is considered be critical inflammatory disorder with major impact patient health. Various theories have been recommended regarding pathophysiology AP and associated pulmonary complications. Methods. Twenty-four adult male albino rats were randomly divided into four groups: control group, (AP), hemin pre-treated...

Abstract Objectives Intestinal ischemia reperfusion (IIR) is a critical emergency situation that needs immediate intervention. Small intestine one of the most sensitive tissues to IR injury and it remains highly morbid condition, with reported mortality rates ranging from 30% 90%. Thus, we aimed evaluate suspected protective role sacubitril/valsartan (SAC/VAL) on IIR injury. Methods Thirty-two adult male Wistar rats were used in our model divided into four groups: sham group, SAC/VAL treated...

OBJECTIVES: This study evaluates the effects produced by H 2 S donor; sodium hydrosulfi de (NaHS), in a renal ischemia/reperfusion (IR) rat model and assesses possible mediating role of nitric oxide (NO) these S' effects.BACKGROUND: For several centuries, hydrogen sulfi (H S) had been known to be highly toxic agent.Recent studies, however, indicated that apart from NO CO, is third "gasotransmitter" involved regulation various physiological functions.Nevertheless, its impact on IR injury...

Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and priming antigen-specific adaptive immunity inflammation. The differences synovial tissue expression of TLRs between seronegative seropositive rheumatoid arthritis (RA) were examined from 9 RA, 5 RA 4 osteoarthritis (OA) patients. Synovitis status was assessed using Krenn's scoring TLR 1–9 by immunohistochemistry. Tissue citrulline content analysed HPLC method. In generally higher than...

Hepatic ischemia-reperfusion (I/R) is an important cause of liver damage in many clinical situations. Toll-like receptor 4 (TLR4)/nuclear factor-kappa B (NF-κB) inflammatory pathway activated hepatic I/R injury. Telmisartan, a selective angiotensin II type 1 antagonist and peroxisome proliferator-activated receptor-gamma (PPARγ) partial agonist, can inhibit the expression pro-inflammatory cytokines. The present work investigated possible protective effect telmisartan against injury explored...

Abstract Polycystic ovary syndrome (PCOS) is one of the most common endocrine and reproductive disorders throughout female age. Cell free therapy [conditioned media (CM) & exosomes (EXO)] a promising approach in regenerative medicine. This study aimed to compare between therapeutic effects stem cell-derived CM on induced animal model polycystic ovary. (PCO) was rats (3–4 weeks old, weighing 70–80 g) by letrozole with dose 1 mg/kg/day dissolved carboxymethylcellulose 1% orally once daily...

Abstract The present study aimed to identify the possible protective effect of diacerein (DIA) on gentamicin (GNT)‐induced parotid toxicity in rats. DIA was administered presence and absence GNT. Thirty‐two Wistar adult male rats were randomly arranged into four groups: control, (50 mg/kg/day), GNT (100 mg/kg) GNT+DIA groups for 8 days. Parotid oxidative stress parameters, besides inflammatory apoptotic biomarkers, evaluated. Salivary flow rate, transient receptor potential canonical 1...

Doxorubicin (DOX) is a widely used cytotoxic anthracycline antibiotic characterized by increased adverse effects that limit its clinical usefulness. Pregnenolone pregnane X receptor (PXR) agonist increases the expression of xenobiotic transporters with anti-inflammatory and antioxidant potential. Thus, we hypothesized pregnenolone would protect against DOX-induced hepatotoxicity.Male Wistar rats (180-200 g) were randomized into four groups (n = 7): Control, Control + (35 mg/kg/day, orally),...

Abstract Ischemic heart disease is a common cardiac health problem. Despite the significant advances in prevention and treatment of this disorder, its incidences complications are very serious. So, search for more antioxidants anti‐inflammatory agents with cardioprotective effects an urgent task. We aimed to evaluate heme oxygenase 1 (HO1) inducer, hemin (HEM), on isoprenaline (ISO)‐induced myocardial damage. Forty‐five Wistar albino rats were used. Animals treated HEM (25 mg/kg/day) i.p . 5...