The aim of this study was to explore different psychosocial impacts on Omani women diagnosed with breast cancer.Semi-structured individual interviews were conducted 19 cancer describe the impact disease their personal and social life. Women recruited from wards out-patient clinics at Sultan Qaboos University Hospital, Muscat.Four main themes emerged. These were: a) factors related psychological distress uncertainty (worry death, interference work family responsibilities, searching for...

PURPOSE Previous studies have reported that cancer incidence trends in Oman varied by tumor site and sex. No comprehensive analysis of all sites had been reported. The objective this study is to analyze calculate the annual percent change (APC) age-standardized rates (ASRs) for all-cancer 61 individual Omani men women from 1996 2019. METHODS We gathered data National Cancer Registry cancers combined sites. estimated APC using Poisson regression. RESULTS ASR population increased 23% (from...

Introduction MicroRNAs (miRNAs) are small non-coding RNA that plays a vital role in cancer progression. Neo-adjuvant chemotherapy (NAC) has become the standard of care for locally advanced breast cancer. The aim this study was to evaluate miRNA alterations during NAC using multiple samples tissue and serum correlate expression with clinico-pathological features patient outcomes. Methods Tissue were collected from patients undergoing at four time points: diagnosis, after first fourth cycle...

Background: Colorectal cancer is the most common gastrointestinal in Oman with an increasing incidence. We here report presenting features, treatment outcomes and survival a University hospital compare our data regional international studies. Materials Methods: Medical records of patients colorectal were reviewed retrospectively between June 2000 December 2013 followed until 2014. Results: A total 162 diagnosed cancer. The majority males (58.6%), median age 56 years. Rectum was involved...

The aim of the present study was to evaluate outcome treatment breast cancer in Oman with an analysis clinico-pathological features, modalities utilized, and prognostic factors. One hundred fifty-two patients diagnosed between January 1996 June 2002 were evaluated retrospectively. Their mean age 48.5 (S.D. +/- 10.8) years, 48% female premenopausal. tumor size according pathology 4.6 3.29)cm, 34.9% 15.8% had stage III or IV disease, respectively. Only 26.3% breast-conserving surgery,...

Breast cancer is the leading cause of cancer-associated mortality in women, with elevated incidence developing countries. This retrospective study included all 122 patients diagnosed breast from January 2003 to December 2008 Sultanate Oman. Age at presentation was 47.41 years (SD±12.88), one-third younger than 40 years. The majority presented stage III (41.2%) and IV (18.2%) cancer. T size (P = .023), skin involvement .003), .004) were significantly associated overall survival. Skin .09),...

The aim of this study was to identify coping strategies experienced by Omani women after breast cancer diagnosis. Individual semistructured interviews were conducted with 19 diagnosed cancer. Several identified including denial, optimism, withdrawal, Islamic beliefs and practices, the support family members health-care providers, but practices commonest. Health-care professionals should be aware respect women's encourage them use reduce psychological symptoms. They also make friends their...

Abstract Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role Neuropilin-1 (NRP-1) its interacting molecules tumor tissue was correlated with cancer progression; however, clinical impact their levels not extensively evaluated. In this cross-sectional study, we found that...

Abstract Background The variability of prognosis within a pathological stage gastric cancer (GC) at presentation, underscores the need for specific biological markers to identify subgroups patients with aggressive course intensive treatment. To our knowledge, this is first study from an Arab population reporting on relationship p53, p27 kip1 , p21 waf1 HER‐2/ neu and Ki67 expression, clinicopathological features their prognostic significance. Methods Formalin‐fixed paraffin‐embedded tumors...

Generation of reactive oxygen species (ROS) is involved in the nephrotoxicity platinum anticancer drugs. This study incubation human embryonic kidney (HEK) 293 cells cell culture media supplemented with cisplatin or oxaliplatin presence absence curcumin, a well-studied antioxidant. Thereafter several indices oxidative stress have been measured, which included glutathione (GSH), total antioxidant capacity (TAC), and enzymes [(superoxide dismutase (SOD), catalase (CAT), peroxidases (GPX)]. The...

Abstract Pathogenesis of nephrotoxicity the synthetic anticancer drug cisplatin (CP) involves generation reactive oxygen species and free radicals in kidney cortex, cysteine prodrug l ‐2‐oxothiazolidine‐4‐carboxylic acid (OTC) has been confirmed to have a strong antioxidant action. Therefore, present work, we aimed at testing possible protective or palliative effect OTC on CP rats. was given an oral dose 150 mg/kg/day for 7 days. On day 7, some these rats were single intraperitoneal...

Nephrotoxicity of the anticancer drug, cisplatin (CP) involves enhanced renal generation reactive oxygen metabolites and lipid peroxidation caused by decreased levels antioxidants antioxidant enzymes. Tetramethylpyrazine (TMP) is known to act as a strong antioxidant. Therefore, in present work, we aimed at testing possible protective or palliative effect TMP on CP nephrotoxicity rats. was given orally dose 80 mg . kg(- 1) day(- for 7 days. Some these rats were single intraperitoneal...

Sildenafil, the first drug for erectile dysfunction, has cardiopulmonary protective actions. A recent study reported that sildenafil given intraperitoneally (i.p.) attenuated cisplatin (CP)-induced nephrotoxicity. Here, we evaluated whether sildenafil, by two different routes and at doses, can attenuate CP-induced nephrotoxicity would also affect renal haemodynamics in CP-treated rats. Six groups of rats were treated with saline (controls), CP [5 mg/kg, once], (0.4 mg/kg/day, i.p. 5 days),...

Background: Colorectal cancer (CRC) represents a heterogeneous group of diseases characterized by uncontrolled growth and spread abnormal cells in the body. CRC vary on basis both biologic features disease its associated lifestyle characteristics. The risk increases with several modifiable factors including obesity, physical inactivity, diet high red or processed meat, heavy alcohol consumption, possibly inadequate intake fruits vegetables. We aimed to establish baseline data for dietary...

Background/Objectives: Pharmacogenomic screening plays a crucial role in optimizing chemotherapy outcomes and minimizing toxicity. Characterizing the baseline distribution of genetic variants specific populations is essential to inform prioritization drug–gene combinations for clinical implementation. The objective this study was investigate pharmacogenetic 36 genes related fluoropyrimidine (FP) pathway among healthy Omani individuals, forming foundation future studies cancer patients...

To analyze the serum levels and prognostic significance of vascular endothelial growth factor (VEGF) -A, -C, -D, their receptors, VEGFR-1 -2 in gastric adenocarcinomas.The VEGF family members were measured 76 control subjects patients with adenocarcinoma using an enzyme-linked immunosorbent assay (ELISA). These measurements correlated clinco-pathological features survival rates.The VEGF-A its receptor, VEGFR-1, significantly higher cancer than healthy donors (t = 2.3, P 0.02 t 4.2, < 0.0001,...

Abstract Vascular endothelial growth factor (VEGF) plays a central role in angiogenesis, tumor growth, and metastasis. We investigated the associations between VEGF gene polymorphisms gastric cancer (GC) risk predisposition prognostic characteristics an Omani population, ethnic group which has not been studied previously. analyzed three (+405 G/C, −460 T/C, +936 C/T) by extraction of genomic DNA from peripheral blood 130 GC patients control subjects followed genotyping using polymerase chain...

AIM:To investigate the associations between CDH1 gene polymorphisms and gastric cancer (GC) risk predisposition. METHODS:We analyzed four (+54 T>C , -160 C>A -616 G>C -3159 ) in an Omani population, by extraction of genomic DNA from peripheral blood 192 patients with GC 170 control participants performed genotyping using sequencing.RESULTS: -AA genotype was associated increased (OR = 3.6, 95% CI: 1.1-11.8)(P 0.03).There no significant association other risk.The haplotype analysis +54...

Abstract Background The adhesion molecule, FAT4, has a tumor suppressor function with critical role in the epithelial-to-mesenchymal-transition (EMT) and anti-malignant growth several cancers. No study investigated yet its epithelial ovarian cancer (EOC) progression. In present study, we examined of FAT4 proliferation metastasis, mechanisms interaction these processes. Methods We have performed cell viability, colony formation, invasion assays cells treated siRNA to knockdown gene...