A5081666411- Angiogenesis and VEGF in Cancer
- Cancer Cells and Metastasis
- Lymphatic System and Diseases
- Axon Guidance and Neuronal Signaling
- Sperm and Testicular Function
- Reproductive Physiology in Livestock
- Adenosine and Purinergic Signaling
- Nanoparticle-Based Drug Delivery
- Drug Transport and Resistance Mechanisms
- Genetic diversity and population structure
- Genetic and phenotypic traits in livestock
Sultan Qaboos University
2012-2023
Neuropilin-1 (NRP-1), a non-tyrosine kinase glycoprotein receptor, is associated with poor prognosis breast cancer, however transcriptomic changes triggered by NRP-1 overexpression and its association chemoresistance in cancer have not yet been explored. BT-474 variant cells were generated stable of the cell line. RNA sequencing qRT-PCR conducted to identify differentially expressed genes. The role an upregulated oncogene, Tenascin C (TNC) pathway was investigated siRNA-mediated knockdown....
Abstract Circulating plasma and peripheral blood mononuclear (PBMCs) cells provide an informative snapshot of the systemic physiological state. Moreover, they a non-invasively accessible compartment to identify biomarkers for personalized medicine in advanced breast cancer. The role Neuropilin-1 (NRP-1) its interacting molecules tumor tissue was correlated with cancer progression; however, clinical impact their levels not extensively evaluated. In this cross-sectional study, we found that...
Breast cancer (BC) metastasis remains a leading cause of female mortality. Neuropilin-1 (NRP-1) is glycoprotein receptor that plays ligand-dependent roles in BC. Clinical studies indicate its correlation with metastatic disease; however, functional role BC uncertain. CRISPR-Cas9 was used to knockout the NRP-1 gene MDA-MB-231 cells, and effects on were determined using an orthotopic mouse engraftment model. expression cells rescued recombinant cDNA silent mutation sgRNA target-adjacent PAM...
Circulating proteins hold a potential benefit as biomarkers for precision medicine. Previously, we showed that systemic levels of neuropilin-1 (NRP-1) and its associated molecules correlated with poor-prognosis breast cancer. To further identify the role NRP-1 interacting in correspondence patients' response to neoadjuvant chemotherapy (NAC), conducted comparative study on blood tissue samples collected from cohort locally advanced cancer patients, before after (NAC). From panel tested...
Patients with locally advanced breast cancer usually receive third-generation neoadjuvant chemotherapy (NAC). Although NAC treatment improved the overall survival, patients' response varies, some acquire resistance and others exhibit a conversion in their molecular subtype. We aimed to identify changes involved attempting find new therapeutic targets different subtypes.
The Arabian tahr/ibex is a small species of goat-antelope-like animal, indigenous to the United Arab Emirates and with larger population in Oman. Although animal was discovered 1894, its numbers continue decline, has been classified on IUCN red list as an endangered species. Little known about male reproduction, specifically, extending cryopreserving semen. This provides crucial tool for ex situ conservation this objective study evaluate sperm characteristics ibex after dilution 2 commercial...