A5018532801- Retinopathy of Prematurity Studies
- Glaucoma and retinal disorders
- Neonatal Respiratory Health Research
- Ophthalmology and Eye Disorders
- Retinal and Optic Conditions
- Neonatal and fetal brain pathology
- Retinal Imaging and Analysis
- Intraocular Surgery and Lenses
- Retinal Diseases and Treatments
- Ophthalmology and Visual Impairment Studies
- Ocular Diseases and Behçet’s Syndrome
- Retinal Development and Disorders
- Corneal surgery and disorders
- Neonatal Health and Biochemistry
- Cardiovascular Conditions and Treatments
- Ocular Oncology and Treatments
- Child Abuse and Related Trauma
- Traumatic Ocular and Foreign Body Injuries
- Retinal and Macular Surgery
- Vestibular and auditory disorders
- Connective tissue disorders research
- Pituitary Gland Disorders and Treatments
- Corneal Surgery and Treatments
- Metabolism and Genetic Disorders
- Ocular Infections and Treatments
Children's Hospital of Philadelphia
2012-2022
University of Pennsylvania
2011-2022
University of Montana
2020-2022
Penn Presbyterian Medical Center
2007-2021
Chengdu Research Base of Giant Panda Breeding
2019
Boston Children's Hospital
2012
University of Pennsylvania Health System
2008
University of Wisconsin–Madison
1994-2005
Cleveland Clinic
2003
Medizinische Hochschule Hannover
2003
<b><i>Background:</i></b> Visual dysfunction is one of the most common causes disability in multiple sclerosis (MS). The Multiple Sclerosis Functional Composite (MSFC), a new clinical trial outcome measure, does not currently include test visual function. <b><i>Objective:</i></b> To examine contrast letter acuity as candidate function for MSFC. <b><i>Methods:</i></b> Binocular testing (Sloan charts) was performed subgroup participants from International Secondary Progressive Avonex...
To determine, with novel software, the feasibility of measuring tortuosity and width retinal veins arteries from digital images infants at risk retinopathy prematurity (ROP).The Computer-Aided Image Analysis Retina (CAIAR) program was developed to enable semiautomatic detection vasculature measurement vessel images. CAIAR tested for accuracy reproducibility measurements by using computer-generated vessel-like lines known frequency, amplitude, width. then clinical correlation readings...
Glaucoma has been recognized as an infrequent but serious complication following surgery for congenital and acquired cataracts in childhood. Little is known concerning the influence of factors on risk glaucoma such age at surgery, type cataract, associated ocular abnormalities, surgery. We reviewed records 240 eyes 155 patients whom cataract had performed between January 1965 July 1990 Children's Hospital, Boston. After excluding those who followed up less than 5 years after 10 years, 125 82...
Purpose:To identify genetic etiologies and genotype/phenotype associations for unsolved ocular congenital cranial dysinnervation disorders (oCCDDs). Methods:We coupled phenotyping with exome or genome sequencing of 467 probands (550 affected 1108 total individuals) genetically oCCDDs, integrating analyses pedigrees, human animal model phenotypes, de novo variants to rare candidate single nucleotide variants, insertion/deletions, structural disrupting protein-coding regions.Prioritized were...
Objective. To evaluate the outcome of tumor necrosis factor-α inhibition (anti-TNF) for pediatric uveitis. Methods. We retrospectively assessed children (age ≤ 18 yrs) with noninfectious uveitis receiving anti-TNF at 5 centers and 1 rheumatology center. Incident treatment success was defined as minimal or no activity ≥ 2 consecutive ophthalmological examinations 28 days apart while taking oral eyedrops/day corticosteroids. Eligible had active and/or were higher corticosteroid doses. Results....
Any ophthalmologist trained within the last 20 years is familiar with this classic textbook, originally published by Drs von Noorden and Hermann Burian in 1974. With its encyclopedic detail coherent, ... will replace preceding editions as standard text logical presentation,<i>Binocular Vision Ocular Motility</i>has become most widely used strabismus print. The popularity of has not been exclusively among clinicians, it referenced scientists exploring ocular motor physiology, binocular...
Purpose: To describe in detail the retinal structure and function of a group patients with cobalamin C (cblC) disease. Methods: Patients (n = 11, age 4 months to 15 years) cblC disease (9/11, early onset) diagnosed by newborn screening underwent complete ophthalmic examinations, fundus photography, near-infrared reflectance imaging, spectral-domain optical coherence tomography (SD-OCT). Electroretinograms (ERGs) were performed subset patients. Results: carried homozygous or compound...
To determine and compare the central corneal thickness (CCT) diameter among groups of patients with childhood glaucomas assess relationship between CCT in these patients.A multicenter observational case series using prospective retrospective data.Patients from Scheie Eye Institute, Children's Hospital Philadelphia, Emory Vanderbilt Medical Centers were eligible to participate. Retrospective data on collected when available; otherwise, asked return ophthalmology clinics for measurements....
Objective: To assess the predictive value of early retinal vascular diameter measurements for development severe retinopathy prematurity (ROP) in high-risk preterm infants.Methods: Digital fundus images were taken 78 eyes at risk ROP with a noncontact camera during fundoscopic examination when infants 31 to 34 weeks postconception age.Vessel diameters measured major superior and inferior temporal arteries veins use VesselMap software.Mean vessel from that developed requiring treatment...
Cryotherapy proved to be far less successful in zone 1 disease than 2 disease, where fortunately greater 75% of the occurs.It is important note that unfavorable outcomes as stage 5 (total retinal detachment) outnumbered 4B (a fold extending through macula) by a ratio 13 1.The treated results were more common proportionately disease.The this study for first time availability treatment improved outlook vision significantly over natural history quickly adopted both United States and worldwide...
<h3>Aims</h3> To determine correlation of width and tortuosity between expert graders computer-assisted image analysis the retina in narrow-field images eyes with retinopathy prematurity. <h3>Methods</h3> 11 digital were selected based on severity prematurity (ROP). Narrow field analysed for vessels using computer-aided (CAIAR), an software, by four ROP experts. Spearman coefficients (ρ) assessed CAIAR grading grading. Intra-class correlations agreement among graders. Width compared...