A5025363387- Clostridium difficile and Clostridium perfringens research
- Hepatitis Viruses Studies and Epidemiology
- Viral gastroenteritis research and epidemiology
- Viral Infections and Vectors
- Cytomegalovirus and herpesvirus research
- Travel-related health issues
- Transplantation: Methods and Outcomes
- Viral-associated cancers and disorders
- Polyomavirus and related diseases
- Antimicrobial Resistance in Staphylococcus
- Mosquito-borne diseases and control
- Organ Transplantation Techniques and Outcomes
- Microscopic Colitis
- Cardiovascular Effects of Exercise
- SARS-CoV-2 detection and testing
- Infective Endocarditis Diagnosis and Management
- Chemical Looping and Thermochemical Processes
- Healthcare professionals’ stress and burnout
- COVID-19 epidemiological studies
- Hematopoietic Stem Cell Transplantation
- Virus-based gene therapy research
- Pneumocystis jirovecii pneumonia detection and treatment
- Burkholderia infections and melioidosis
- Legionella and Acanthamoeba research
- Acute Lymphoblastic Leukemia research
Beth Israel Deaconess Medical Center
2017-2024
Harvard University
2011-2024
Massachusetts General Hospital
2011-2024
Beth Israel Deaconess Hospital
2022
Mount Auburn Hospital
2011-2020
Providence College
2020
Community Health Center
2020
University of Massachusetts Chan Medical School
2009-2012
Office of Infectious Diseases
2005
New therapies are needed to manage the increasing incidence, severity, and high rate of recurrence Clostridium difficile infection.We performed a randomized, double-blind, placebo-controlled study two neutralizing, fully human monoclonal antibodies against C. toxins A (CDA1) B (CDB1). The were administered together as single infusion, each at dose 10 mg per kilogram body weight, in patients with symptomatic infection who receiving either metronidazole or vancomycin. primary outcome was...
Hepatitis C virus (HCV) infection is a leading cause of liver transplantation and there an urgent need to develop therapies reduce rates HCV transplanted livers. Approved therapeutics for are poorly tolerated limited efficacy in this patient population. Human monoclonal antibody HCV1 recognizes highly-conserved linear epitope the E2 envelope glycoprotein (amino acids 412–423) neutralizes broad range genotypes. In chimpanzee model, single dose 250 mg/kg delivered 30 minutes prior infusion...
Case reports, case series and cohort studies have been published describing the clinical course outcomes of people living with human immunodeficiency virus (PLWH) who contract coronavirus disease 2019 (COVID-19) pneumonia. However, majority work focuses on patients well-controlled (HIV) antiretroviral therapy (ART).We present a new diagnosis HIV Acquired Immune Deficiency Syndrome (AIDS) made simultaneously to COVID-19, co-infection pneumocystis jirovecii pneumonia (PJP) possible...
Listeria monocytogenes vectors have shown promise for delivery of viral and tumor antigens in animals. We used two mutant vector strains deleted actA/plcB (BMB72) actA/inlB (BMB54), engineered both to secrete a heterologous nucleoprotein antigen from the Influenza A virus. Strains were evaluated vitro mice. Twenty-two healthy volunteers received single oral doses either strain physiological study safety, shedding, immunogenicity. Volunteers observed hospital seven days had daily blood...
Background. Immunosuppression in solid organ transplantation (SOT) increases the risk of Epstein–Barr virus (EBV) DNAemia, which may herald development posttransplant lymphoproliferative disease (PTLD). Few studies have characterized incidence, factors, and clinical impact EBV DNAemia adult SOT recipients (SOTR). Methods. A single-center, retrospective review (≥18 years) SOTR between 01 January 2015 31 December 2019 was conducted. Patients were stratified by primary study endpoint (whole...
Abstract Bloodstream infections (BSIs) account for 18% of bacterial in the first year after solid organ transplantation (SOT). Enterococcus accounts up to 20% BSIs this population, with vancomycin‐resistant enterococcus (VRE) posing a particular risk. This is retrospective, case‐control study adult liver and kidney transplant recipients between 01/01/2016 06/30/2021 that characterizes epidemiology outcomes enterococcal transplantations at single institution. Subjects an BSI within 6 months...
Legionella pneumophila is a common cause of community-acquired pneumonia. Central nervous system dysfunction common, and diagnosis in the absence pulmonary symptoms can be challenging. Here we describe an atypical clinical presentation infection patient with HIV who was found to have unusual neuroradiologic lesion that further served obscure diagnosis. This first such description Legionellosis coinfection. A 43 year-old positive man presented our hospital dysarthria, fevers, headache,...
To report a case of systemic and ocular toxoplasmosis in an immunocompetent patient, who developed myocarditis with resulting cardiogenic shock multiple organ failure, followed by bilateral panuveitis masquerading as endogenous endophthalmitis.Single images.A 59-year-old man history monoclonal gammopathy undetermined significance associated scleromyxedema but otherwise was admitted to the intensive care unit for failure due presumed viral myocarditis. After hospital discharge, ophthalmic...
A 24-year-old sailor presented to the emergency department with a seven-day history of shortness breath, occasional substernal chest pain, increasing abdominal girth, and nausea vomiting. He reported leg swelling weight gain 14 kg during preceding three weeks.
Superficial dermatophyte infections are common in the general population and readily treated with topical antifungals. Deeper invasion is rare, dissemination to visceral organs extremely uncommon. We describe a 66-year-old renal transplant recipient who developed disseminated Trichophyton rubrum infection while undergoing treatment for acute humoral rejection. The presented as facial rash subsequent lungs chest wall. All sites of improved combination administration oral posaconazole...
Abstract Background Burnout, “a psychological syndrome of emotional exhaustion (EE), depersonalization (DP), and reduced personal accomplishment (PA),” is a well-described problem in the medical community. National surveys report 45% practicing physicians 60% residents fellows are burnt out. A longitudinal study students reported burnout, as well career choice regret 14% trainees. There little data about burnout Infectious Diseases (ID) physicians, including fellows. We sought to measure...
Abstract Background Immunosuppression in solid organ transplantation (SOT) increases the risk of Epstein-Barr virus (EBV) DNAemia, which may herald development post-transplant lymphoproliferative disease (PTLD). The objective this study was to characterize epidemiology and factors for EBV DNAemia describe impact these on PTLD a cohort SOT recipients. Methods We retrospectively examined adult (≥18 years) recipients between 1/1/2015 12/31/2019. Demographics, immunosuppression, clinical...