A5077588358- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Spondyloarthritis Studies and Treatments
- Autoimmune and Inflammatory Disorders Research
- Health Systems, Economic Evaluations, Quality of Life
- Psoriasis: Treatment and Pathogenesis
- Vitamin D Research Studies
- Lymphoma Diagnosis and Treatment
- Bone and Joint Diseases
- Mobile Health and mHealth Applications
- Chronic Lymphocytic Leukemia Research
- Statistical Methods in Clinical Trials
- Viral Infections and Immunology Research
- Telemedicine and Telehealth Implementation
- Workplace Health and Well-being
- Systemic Sclerosis and Related Diseases
- Hip and Femur Fractures
- HER2/EGFR in Cancer Research
- Frailty in Older Adults
- Statistical Methods and Bayesian Inference
- Eosinophilic Esophagitis
- Chronic Disease Management Strategies
- Emergency and Acute Care Studies
- Employment and Welfare Studies
- Meta-analysis and systematic reviews
Amsterdam University Medical Centers
2019-2024
Vrije Universiteit Amsterdam
2019-2023
Amsterdam UMC Location Vrije Universiteit Amsterdam
2013-2022
Center for Rheumatology
2011-2022
Public Health Service of Amsterdam
2020-2022
NIHR Manchester Biomedical Research Centre
2019
Cancer Research And Biostatistics
2017-2019
Arthritis Society
2019
Research Canada
2019
National Health Service
2019
OBJECTIVE Low vitamin D status has been associated with impaired glycemic control in patients type 2 diabetes. The purpose of our study was to evaluate the effect supplementation on RESEARCH DESIGN AND METHODS This randomized, double-blind, placebo-controlled trial conducted 275 adult diabetes without insulin treatment. Patients were randomly assigned receive either D3 (50,000 IU/month) or placebo for 6 months. To assess primary outcome study, change HbA1c, we performed a linear regression...
Objective To compare vitamin D status in women with PCOS versus fertile and subsequently evaluate the association between metabolic disturbances women. Methods We conducted a cross-sectional comparison study of 639 449 Serum 25-hydroxyvitamin (25(OH)D) was stratified into severe deficient (< 25 nmol/l), insufficient (25–50 moderate (50–75 nmol/l) adequate (> 75 status. The main outcome measures were difference women, serum 25(OH)D only. Results significantly lower compared to controls (mean...
Objective We developed a smartphone application for patients with rheumatoid arthritis (RA) that allows them to self‐monitor their disease activity in between clinic visits by answering weekly Routine Assessment of Patient Index Data 3. This study was undertaken assess the safety (noninferiority Disease Activity Score 28 joints using erythrocyte sedimentation rate [DAS28‐ESR]) and efficacy (reduction number visits) patient‐initiated care assisted app, compared usual care. Methods A 12‐month,...
<h3>Background</h3> Early, intensive treatment of rheumatoid arthritis (RA) with the combination (initially high dose) prednisolone, methotrexate and sulfasalazine (COBRA therapy) considerably lowers disease activity suppresses radiological progression, but is infrequently prescribed in daily practice. Attenuating COBRA regimen might lessen concerns about side effects, efficacy such strategies unknown. <h3>Objective</h3> To compare 'COBRA-light' strategy only two drugs, comprising a lower...
Abstract Non-invasive imaging of arthritis activity in rheumatoid (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with tracer ( R )-[ 11 C]PK11195 were encouraging, but the signal could be further improved by reduction background uptake. Recently, novel [ 18 F]fluoro-PEG-folate was developed. This showed excellent targeting folate receptor β on activated macrophages synovial tissue a preclinical arthritic...
Background Recently, we documented the likely non-inferiority of Combinatietherapie Bij Reumatoïde Artritis (COBRA)-light therapy (methotrexate increased to 25 mg/week with initial prednisolone 30 mg/day) compared original COBRA 7.5 mg/week, sulfasalazine 2 g/day, 60 after 26 weeks in patients early active rheumatoid arthritis (RA). Objective To assess COBRA-light versus 1 year terms disease activity (DAS44), functional outcome (Health Assessment Questionnaire (HAQ)) and radiographic...
Mobile devices such as smartphones and tablets have surged in popularity recent years, generating numerous possibilities for their use health care mobile (mHealth) tools. One advantage of mHealth is that it can be provided asynchronously, signifying providers patients are not communicating real time. The integration asynchronous into daily clinical practice might therefore help to make more efficient with rheumatoid arthritis (RA). benefits been reviewed various medical conditions, diabetes...
How to perform an intention treat (ITT) analysis when a patient has baseline value but no follow-up measurements is problematic. The purpose of this study was compare different methods that deal with problem, i.e. imputation (standard and alternative mixed model analysis), single (i.e. carried forward), multiple (selective non-selective).We used simulation scenarios regarding 1) the association between missingness value, 2) whether patients did or not receive treatment, 3) percentage missing...
Objectives Several trials to test the efficacy of a pharmacological intervention aimed at primary prevention rheumatoid arthritis (RA) are ongoing or have recently been completed. A common issue in these is severe difficulty with patient recruitment. In order enhance recruitment, this qualitative study identified barriers and facilitators individuals risk RA participate trial. Methods Individuals developing (ie, arthralgia anticitrullinated protein antibodies and/or factor without...
Telemonitoring disease activity with electronic patient-reported outcomes (ePROs) may reduce the workload of rheumatic care by decreasing outpatient clinic visits. However, low adherence to reporting ePROs is frequently observed. Our objective was identify facilitators and barriers weekly monitoring ePROs. Patients rheumatoid arthritis (RA), psoriatic (PsA), or ankylosing spondylitis (AS) who recently participated in one two telemonitoring studies completed a smartphone app, were invited...
The randomised placebo-controlled GLORIA (Glucocorticoid LOw-dose in RheumatoId Arthritis) trial evaluated the benefits and harms of prednisolone 5 mg/day added to standard care for 2 years patients aged 65+ with rheumatoid arthritis (RA). Here, we studied disease activity, flares possible adrenal insufficiency after blinded withdrawal study medication.Per protocol, successfully completing 2-year period linearly tapered stopped medication 3 months. We compared changes activity taper between...
Medical students from ethnic minorities underperform in knowledge and skills assessments both pre-clinical clinical education compared to the majority group. Motivation, which influences learning academic performance of medical students, might play an important role explaining these differences, but is under-investigated. This study aimed compare two types motivation (autonomous controlled) minority (Western non-Western) (Dutch) their association with performance. In a cross-sectional study,...
Clinical studies with work participation (WP) as an outcome domain pose particular methodological challenges that hamper interpretation, comparison between and meta-analyses.To develop Points to Consider (PtC) for design, analysis reporting of patients inflammatory arthritis include WP a primary or secondary domain.The EULAR Standardised Operating Procedures were followed. A multidisciplinary taskforce 22 experts including rheumatic diseases, from 10 countries Canada, identified methodologic...
Background Telemedicine based on self-measurement of disease activity could be one the key components to create health care system future. Previous publications in various medical fields have shown that it is possible safely telemonitor patients while reducing number outpatient clinic visits. For this purpose, we developed a mobile phone app for with rheumatoid arthritis (RA), which allows them self-monitor their disease. Objective The objective study assess safety and efficacy...
To investigate the effects of changing inflammation on lipid levels in ankylosing spondylitis.In a cohort 230 patients, were measured at baseline and after 52 weeks treatment with tumor necrosis factor-α-blocking agents (anti-TNF).Total cholesterol (TC; +4.6%), low-density lipoprotein (+4.3%), high-density (HDL-C; +3.7%) increased upon treatment. Changes most evident patients substantial reduction inflammatory (TC +8.2% vs +1.6% HDL-C +8.3% +2.2% C-reactive protein ≥ 10 mg/l normalizing CRP...
To assess the efficacy and safety of initial COBRA-light vs COBRA therapy in RA patients after a 4-year follow-up period.In trial, 162 consecutive with recent-onset were randomized to either (prednisolone MTX) or (prednisolone, MTX SSZ) for 1 year. After year, treatment was continued without protocol, adjusted by treating physician according clinical judgement, preferably treat-to-target strategy. Four years trial initiation, all invited participate extension study, which interviewed...
To describe the development and assess psychometric properties of novel 'Symptoms in Persons At Risk Rheumatoid Arthritis' (SPARRA) questionnaire individuals at risk rheumatoid arthritis (RA) to quantify their symptoms.The items were derived from a qualitative study patients with seropositive arthralgia. The was administered 219 RA on basis symptoms or autoantibody positivity: 74% factor and/or anticitrullinated protein antibodies positive, 26% seronegative. Validity, reliability...
Abstract Background Societal expenditures on work-disability benefits is high in most Western countries. As a precursor of long-term work restrictions, sickness absence (LTSA) under continuous attention policy makers. Different healthcare professionals can play role identification persons at risk LTSA but are not well trained. A prediction model support stratification to initiate preventative interventions. Unfortunately, current models lack generalizability or do include comprehensive set...
Older adults presenting to the emergency department (ED) are at high risk of adverse health outcomes. This study aimed evaluate accuracy 4 frequently used screening instruments for prediction outcomes among older in ED.This was a prospective cohort patients ≥70 years age ED 2 hospitals Netherlands. Screening included acutely patient program (APOP) (providing scores-functional decline [APOP1] and mortality [APOP2]), International Resident Assessment Instrument Emergendy Department screener...