A5042628953- Rheumatoid Arthritis Research and Therapies
- Bone and Joint Diseases
- Medical Imaging Techniques and Applications
- Spondyloarthritis Studies and Treatments
- Systemic Lupus Erythematosus Research
- Osteomyelitis and Bone Disorders Research
- HER2/EGFR in Cancer Research
- Orthopedic Infections and Treatments
- Infectious Diseases and Tuberculosis
- Click Chemistry and Applications
- Cytokine Signaling Pathways and Interactions
- Viral Infections and Immunology Research
- Monoclonal and Polyclonal Antibodies Research
- Advanced Biosensing Techniques and Applications
- Hematological disorders and diagnostics
- Peripheral Neuropathies and Disorders
Amsterdam University Medical Centers
2019-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2017-2022
Center for Rheumatology
2017-2022
University Medical Center
2017-2018
University Hospital and Clinics
2017-2018
Abstract Non-invasive imaging of arthritis activity in rheumatoid (RA) patients using macrophage PET holds promise for early diagnosis and therapeutic response monitoring. Previously obtained results with tracer ( R )-[ 11 C]PK11195 were encouraging, but the signal could be further improved by reduction background uptake. Recently, novel [ 18 F]fluoro-PEG-folate was developed. This showed excellent targeting folate receptor β on activated macrophages synovial tissue a preclinical arthritic...
Excessive bone formation is an important hallmark of AS. Recently it has been demonstrated that axial bony lesions in AS patients can be visualized using 18F-fluoride PET-CT. The aim this study was to assess whether uptake clinically active related focal spine biopsies and sensitive change during anti-TNF treatment. Twelve anti-TNF-naïve [female 7/12; age 39 years (SD 11); BASDAI 5.5 ± 1.1] were included. 18 F-fluoride PET-CT scans performed at baseline two patients, obtained from...
Background Positron emission tomography (PET) imaging of macrophages using the translocator protein (TSPO) tracer (R)-[11C]PK11195 has shown promise to image rheumatoid arthritis (RA). To further improve TSPO PET for RA imaging, second generation tracers [11C]DPA-713 and [18F]DPA-714 have recently been evaluated pre-clinically showing better characteristics. Objective A clinical proof concept study evaluate visualize in patients. Methods patients (n = 13) with at least two active hand joints...
Objective To determine whether macrophage positron emission tomography (PET)/computed (CT) imaging using ( R )-[ 11 C]PK11195 at 0 and 2 weeks is associated with clinical response 13 in patients early rheumatoid arthritis (RA). Methods Whole-body PET/CT scans were performed baseline after of COBRA-light (combination therapy methotrexate prednisone) treatment 35 clinically active RA. Clinical assessment (Disease Activity Score 44 joints (DAS44)) was 0, treatment. assessed visually by two...
To relate [18F]fluoride uptake on PET with abnormalities magnetic resonance imaging (MRI) and conventional radiography (CR) in ankylosing spondylitis (AS) patients.Ten clinically active AS patients (female 6/10, age 38 ± 11 years) were included, both spine SI-joints examined. scans dichotomously scored for enhanced uptake, MRI fatty lesions, erosions, ankylosis, bone marrow edema (BME), CR was syndesmophytes, ankylosis. The overlap of lesions across all modalities evaluated through...
Treatment for rheumatoid arthritis (RA) should be started as early possible to prevent destruction of bone and cartilage in affected joints. A new diagnostic tool both diagnosis therapy monitoring would valuable reduce permanent joint damage. Positron emission tomography (PET) imaging macrophages is a previously demonstrated non-invasive means visualize (sub)clinical RA patients. We developed kinetic model quantify uptake the macrophage tracer [11C]DPA-713...
<h3>Background</h3> Imaging arthritis activity in rheumatoid (RA) patients using PET macrophage tracers holds promise for both early diagnostics and monitoring response to therapy (1,2). Previously, (<i>R</i>)-[<sup>11</sup>C]PK11195 has been used, but this tracer is limited due high background uptake, especially bone marrow. Recently, a novel tracer, [<sup>18</sup>F]fluoro-PEG-folate, was developed, which showed excellent targeting of the folate receptor beta on activated macrophages...
Background: Clinical assessment of arthritis is the cornerstone in diagnosis and treatment rheumatoid (RA). Nevertheless, reliable determination (sub)clinical can be difficult, especially feet. Advanced imaging techniques may contribute to early therapy monitoring through sensitive detection (quantitative) synovitis. Previously, it has been demonstrated that macrophage using ( R )-[ 11 C]PK11195 positron emission tomography (PET) allows for highly specific RA disease activity hands. (1,2)...
Background: Treat-to-target strategies for rheumatoid arthritis (RA) have shown significant improvements in therapy outcomes. Nevertheless, it usually takes a minimum of 12 weeks before clinical assessment treatment response can be made. Quantitative positron emission tomography (PET) has potential to predict at very early stage the RA patients. (1) In particular, macrophage imaging by [ 11 C]-( R )-PK11195 PET allows highly sensitive and specific disease activity. (2,3) Objectives: To...
To investigate the potential of whole-body positron emission tomography/computed tomography (PET/CT) with a macrophage tracer to image arthritis in patients early rheumatoid (RA). Thirty-five previously untreated, clinically active RA underwent PET/CT scanning (R)-[11C]PK11195 addition clinical assessment (Disease Activity Score 44 joints [DAS44]). Tracer uptake was assessed quantitatively as standardized values (SUVs). In addition, 2 readers blinded visually scored joints. Clinical and PET...
<h3>Background</h3> Excessive bone formation is an important hallmark of ankylosing spondylitis (AS). Recently, it has been demonstrated that axial bony lesions in AS patients can be visualized using [<sup>18</sup>F]fluoride PET-CT. This technique may also provide opportunities to monitor changes during therapy. <h3>Objectives</h3> To assess (1)changes uptake before and 12 weeks after treatment with TNF-inhibitors (TNFi) (2)whether on PET related focal spine biopsies. <h3>Methods</h3> Twelve...
<h3>Background</h3> Treatment of rheumatoid arthritis (RA) should be initiated as early possible to prevent further damage and functional disability.<sup>1</sup> However, clinical assessment treatment response usually takes 12 weeks or longer. Tools that detect earlier can improve timely decision. Previously, positron emission tomography (PET) using the macrophage tracer [11C]-(R)-PK11195 has shown promise for both diagnosis monitoring therapy in RA patients.<sup>2,3</sup>...