A5029473052- Rheumatoid Arthritis Research and Therapies
- Bone health and osteoporosis research
- Systemic Lupus Erythematosus Research
- Lymphoma Diagnosis and Treatment
- Nutrition, Genetics, and Disease
- Chronic Lymphocytic Leukemia Research
- Autoimmune and Inflammatory Disorders Research
- Vitamin D Research Studies
- Nutritional Studies and Diet
- Nutrition and Health in Aging
- Biosimilars and Bioanalytical Methods
- Bone and Joint Diseases
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Congenital Diaphragmatic Hernia Studies
- Acute Lymphoblastic Leukemia research
- Colorectal and Anal Carcinomas
- Colorectal Cancer Surgical Treatments
- Spondyloarthritis Studies and Treatments
- Viral Infections and Immunology Research
- Gastroesophageal reflux and treatments
- Sarcoidosis and Beryllium Toxicity Research
- Hip disorders and treatments
- Colorectal Cancer Screening and Detection
- Health and Lifestyle Studies
- Folate and B Vitamins Research
Amsterdam University Medical Centers
2021-2022
Vrije Universiteit Amsterdam
2021-2022
Amsterdam UMC Location Vrije Universiteit Amsterdam
2015-2018
University Medical Center
2015-2018
University Hospital and Clinics
2015-2018
Assistance Publique – Hôpitaux de Paris
2017
Pitié-Salpêtrière Hospital
2017
Center for Rheumatology
2014-2017
University of the West of England
2017
Sorbonne Université
2017
Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints affecting 1% world population. It has major impact on patients through disability and associated comorbidities. Current treatment strategies have considerably improved prognosis, but recent innovations (especially biologic drugs new class so-called "JAK/STAT inhibitors") important safety issues are very costly. Glucocorticoids (GCs) highly effective in RA, could reduce need for expensive with agents. However, despite...
Treatment with initial high-dose prednisolone and a combination of methotrexate (MTX) sulfasalazine (SSZ) according to the COBRA regimen (Dutch acronym for combinatietherapie bij reumatoide artritis, ‘combination therapy rheumatoid arthritis'), has repeatedly been demonstrated be very effective in early arthritis (RA). is superior monotherapy SSZ MTX, also associated good long-term outcome, as safe other treatment regimes, performs well MTX tumor necrosis factor antagonist infliximab. A...
The Outcome Measures in Rheumatology (OMERACT) working group on the patients' perspective remission rheumatoid arthritis (RA) has been this topic since 2010. At OMERACT 2016, progress and preliminary data validity of measurement instruments for pain, fatigue, independence RA were presented, future directions explored.A special interest was organized, which current presented. ongoing study that aimed to validate a state low disease activity or construct discriminative capacity evaluated...
Calcium supplements are prescribed for prevention of osteoporotic fractures, but there is controversy whether excess calcium intake associated with cardiovascular events. While an accurate estimation dietary a prerequisite to prescribe the adequate amount supplementation, most tools estimating time-consuming. The aim this study validate short list (SCaIL) that feasible in daily clinical practice.Based on food groups contributing and portion sizes determined earlier study, three-item, 1-min...
Clinical response and remission are defined in multiple ways measured with different instruments, resulting substantial variation of the proportion patients classified as being remission. Therefore, agreement between patient-perceived, physician-perceived clinical definitions was determined early rheumatoid arthritis (RA) patients. And secondly, differences patient-reported outcomes, remission, not self-perceived were assessed. In 84 RA patients, who received methotrexate glucocorticoids,...
The aim of this study was to investigate the effect treat-to-target combination therapy with intensification at 13 weeks in early RA.Early RA patients were classified as being high or low risk worsening based on disease activity and prognostic factors. High-risk received COBRA-light (prednisolone 30 mg/day tapered 7.5 mg/day, MTX increasing 25 mg/week), low-risk monotherapy mg/week. primary outcome (target) DAS44 < 1.6 EULAR good response 26 weeks. At weeks, non-responders randomized...
Patients have identified pain, fatigue and independence as the most important domains that need to be improved define remission in rheumatoid arthritis (RA). This study validated instruments for these evaluated their added value ACR/EULAR Boolean definition.Patients with a 28-joint Disease Activity Score (DAS28) ≤3.2 or self-perceived (declaring disease activity 'as good gone') from Netherlands, Portugal, Australia, Canada, were assessed at 0, 3 6 months patient-reported outcomes WHO-ILAR RA...
<h3>Background</h3> Rheumatoid arthritis (RA) patients increasingly reach a state of absence disease activity, or remission. However, the proportion classified as in remission varies substantially between definitions and are often determined by activity score (DAS). But, importance patients9 perspective is recognized, which result discordance physician assessment. <h3>Objectives</h3> To determine how physicians agree on according to different definitions, well difference patient reported...
Background Modern trials in RA often have a strict protocolized treat-to-target design, whereas daily practice shared decision making is the preferred way to manage treatment. Objectives To document protocol violations an early trial that illustrate potential conflicts between these strategies. Methods In COBRA trial, treatment-naive patients were classified into low- and high-risk group, treated according two different protocols. Treatment target was minimal disease activity (DAS44 <1.6)...
Searchable abstracts of presentations at key conferences on calcified tissues ISSN 2052-1219 (online)
<h3>Background</h3> Calcium supplements are widely used for the prevention and treatment of osteoporosis. However, recent literature suggests that too much calcium supplementation may be associated with cardiovascular events (1). For this reason, should based on actual adequate dietary intake. A previously designed intake list appeared to invalid (2) other alternatives time consuming clinical practice. Therefore, we developed a new list, accurately estimate intake, which was validated in...
<h3>Background</h3> Vitamin D deficiency is highly common in patients with rheumatoid arthritis (RA) (1). In vitro, vitamin has anti-inflammatory effects and been linked to disease activity RA due its immuno-modulatory properties (1,2). <h3>Objectives</h3> To investigate the association between status newly diagnosed before start of therapy. <h3>Methods</h3> Consecutive active, (symptom duration <2 years), were randomized for treatment COBRA or COBRA-light therapy (3). Before therapy,...
<h3>Background</h3> Recently, we showed that treatment with COBRA-light therapy including prednisone initially 30 mg/day, was as effective the original COBRA scheme, 60 mg/day [1,2], in of rheumatoid arthritis (RA). Since high-dose glucocorticoids are associated bone loss and vertebral nonvertebral fractures, investigated differences mineral density (BMD) after one year both arms. <h3>Objectives</h3> To compare 1-year changes BMD (lumbar spine [L1-L4], total hip, femoral neck) between...
<h3>Background</h3> Calcium supplements are widely used for the prevention and treatment of osteoporosis. However, in recent literature there is a controversy whether or not excessive calcium supplementation may be associated with increased risk cardiovascular events (1-2). In daily practice, rheumatologists at VUmc use short list to estimate dietary intake calcium, which basis prescribed amount supplementation. An accurate estimation important able prescribe adequate reach recommended...
<h3>Background</h3> Treatment of rheumatoid arthritis (RA) should be initiated as early possible to prevent further damage and functional disability.<sup>1</sup> However, clinical assessment treatment response usually takes 12 weeks or longer. Tools that detect earlier can improve timely decision. Previously, positron emission tomography (PET) using the macrophage tracer [11C]-(R)-PK11195 has shown promise for both diagnosis monitoring therapy in RA patients.<sup>2,3</sup>...