Thomas Klausch

ORCID: 0000-0001-8771-1742
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About
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Research Areas
  • Statistical Methods and Bayesian Inference
  • Survey Methodology and Nonresponse
  • Statistical Methods and Inference
  • Health Systems, Economic Evaluations, Quality of Life
  • Survey Sampling and Estimation Techniques
  • Colorectal Cancer Screening and Detection
  • Esophageal Cancer Research and Treatment
  • Bayesian Methods and Mixture Models
  • Rheumatoid Arthritis Research and Therapies
  • Psychometric Methodologies and Testing
  • Respiratory Support and Mechanisms
  • Advanced Causal Inference Techniques
  • Sepsis Diagnosis and Treatment
  • Machine Learning and Data Classification
  • Musculoskeletal pain and rehabilitation
  • Biosimilars and Bioanalytical Methods
  • Spondyloarthritis Studies and Treatments
  • Media, Gender, and Advertising
  • Healthcare Policy and Management
  • Data Stream Mining Techniques
  • Reconstructive Surgery and Microvascular Techniques
  • Esophageal and GI Pathology
  • Gene expression and cancer classification
  • Media Influence and Health
  • Machine Learning and Algorithms

Amsterdam University Medical Centers
2019-2025

Vrije Universiteit Amsterdam
2019-2024

University Medical Center
2019-2023

Amsterdam UMC Location Vrije Universiteit Amsterdam
2016-2023

University of Amsterdam
2023

University Hospital and Clinics
2019

Centraal Bureau voor de Statistiek
2013-2017

Utrecht University
2013-2017

Amsterdam Public Health
2017

Maastricht School of Management
2017

<h3>Importance</h3> Understanding mechanisms associated with prolonged cognitive health in combination exceptional longevity might lead to approaches enable successful aging. <h3>Objective</h3> To investigate trajectories of functioning centenarians across domains, and examine the association these factors underlying reserve, physical health, postmortem levels Alzheimer disease (AD)–associated neuropathology. <h3>Design, Setting, Participants</h3> This cohort study used neuropsychological...

10.1001/jamanetworkopen.2020.31654 article EN cc-by-nc-nd JAMA Network Open 2021-01-15

This study applies ordinal confirmatory factor analysis for multiple groups to assess equivalence of scale, random errors and systematic (nonrandom) attitudinal questions surveyed on rating scales under different survey modes (Face-to-Face [F2F], Telephone, Paper, Web). Empirical findings from a large-scale experiment are presented. Consistent with theoretical expectations, interviewer- self-administered surveys measured all assessed systematically scales, bias, differing extents error....

10.1177/0049124113500480 article EN Sociological Methods & Research 2013-08-01

ABSTRACT For clinical prediction applications, we are often faced with small sample size data compared to the number of covariates. Such pose problems for variable selection and prediction, especially when covariate‐response relationship is complicated. To address these challenges, propose incorporate external information on covariates into Bayesian additive regression trees (BART), a sum‐of‐trees model that utilizes priors tree parameters prevent overfitting. information, an empirical Bayes...

10.1002/sim.70004 article EN cc-by Statistics in Medicine 2025-02-18

Objectives The Patient-Reported Outcomes Measurement Information System (PROMIS) is a universally applicable set of instruments, including item banks, short forms and computer adaptive tests (CATs), measuring patient-reported health across different patient populations. PROMIS CATs are highly efficient the use in practice considered feasible with little administration time, offering standardized routine monitoring. Before an bank can be used as CAT, psychometric properties have to examined....

10.1371/journal.pone.0192187 article EN cc-by PLoS ONE 2018-02-12

Rheumatoid arthritis (RA) is a chronic inflammatory disease of the joints affecting 1% world population. It has major impact on patients through disability and associated comorbidities. Current treatment strategies have considerably improved prognosis, but recent innovations (especially biologic drugs new class so-called "JAK/STAT inhibitors") important safety issues are very costly. Glucocorticoids (GCs) highly effective in RA, could reduce need for expensive with agents. However, despite...

10.1186/s13063-017-2396-3 article EN cc-by Trials 2018-01-25

Confounding is a common issue in epidemiological research. Commonly used confounder-adjustment methods include multivariable regression analysis and propensity score methods. Although it practice to assess the linearity assumption for exposure-outcome effect, most researchers do not of relationship between confounder exposure outcome before adjusting analysis. Failing take true non-linear functional form confounder-exposure confounder-outcome associations into account may result an under- or...

10.1186/s12874-022-01817-0 article EN cc-by BMC Medical Research Methodology 2023-01-12

Summary This study compares the extent of selection error (non-response and coverage error) evoked by four major contemporary modes data collection (face to face, telephone, mail Web) three sequential mixed mode designs (telephone, Web with face-to-face follow-up) for case Dutch Crime Victimization Survey. Sociodemographic characteristics target variables from survey serve as benchmark variables. A special two-wave experimental design allows studying differences in on Survey independently...

10.1111/rssa.12102 article EN Journal of the Royal Statistical Society Series A (Statistics in Society) 2015-01-27

Abstract Background Antibiotic exposure is often inadequate in critically ill patients with severe sepsis or septic shock and this associated worse outcomes. Despite markedly altered rapidly changing pharmacokinetics these patients, guidelines clinicians continue to rely on standard dosing schemes. To address challenge, we developed AutoKinetics, a clinical decision support system for antibiotic dosing. By feeding large amounts of electronic health record patient data into pharmacokinetic...

10.1186/s13063-019-3911-5 article EN cc-by Trials 2019-12-01

This study evaluated three types of bias—total, measurement, and selection bias (SB)—in sequential mixed-mode designs the Dutch Crime Victimization Survey: telephone, mail, web, where nonrespondents were followed up face-to-face (F2F). In absence true scores, all biases estimated as mode effects against two different benchmarks. single-mode benchmark (SMB), a F2F reference survey. an alternative analysis, “hybrid-mode benchmark” (HMB) was used, mix measurements web survey SB A special...

10.1177/0049124115585362 article EN Sociological Methods & Research 2015-07-06

Abstract Background Despite advances in treatments, 30% to 50% of stage III‐IV head and neck squamous cell carcinoma (HNSCC) patients relapse within 2 years after treatment. The Big Data Decide (BD2Decide) project aimed build a database for prognostic prediction modeling. Methods Stage HNSCC with locoregionally advanced treated curative intent (1537) were included. Whole transcriptomics radiomics analyses performed using pretreatment tumor samples computed tomography/magnetic resonance...

10.1002/hed.26515 article EN cc-by-nc-nd Head & Neck 2020-10-27

Abstract. Theory of mind, defined as attributing intentions, feelings, and thoughts to others, is a key capacity in building mental models narratives. Shot scale, referring the relative size figure on screen, effectively regulates theory mind relevant visual cues carried by faces. However, research into effect shot scale responses narrative almost nonexistent. The aim present study was investigate extent which influences responding film viewers. Four short animated movies were annotated for...

10.1027/1864-1105/a000189 article EN Journal of Media Psychology Theories Methods and Applications 2016-08-26

Abstract Reinterview designs are a potential tool to estimate and adjust for mode measurement effects, that is, relative differences in mode-specific error bias. In 2011, reinterview design was successfully applied the Dutch Crime Victimization Survey, which led redesign of survey. may, however, be very costly, especially when face is included as survey mode. The crucial question whether benefits outweigh costs, increase accuracy statistics worth investment. answer this depends heavily on...

10.1093/jssam/smae011 article EN Journal of Survey Statistics and Methodology 2024-03-28

We propose BayesPIM, a Bayesian prevalence-incidence mixture model for estimating time- and covariate-dependent disease incidence from screening surveillance data. The method is particularly suited to settings where some individuals may have the at baseline, baseline tests be missing or incomplete, test has imperfect sensitivity. Building on existing PIMixture framework, which assumes perfect sensitivity, BayesPIM accommodates uncertain accuracy by incorporating informative priors. By...

10.48550/arxiv.2412.16065 preprint EN arXiv (Cornell University) 2024-12-20

In mixed-mode surveys, mode differences in measurement bias, also called effects or effects, continue to pose a problem survey practitioners. this paper, we discuss statistical adjustment of bias the level benchmark context inference from data. Doing so requires auxiliary information, which suggest collecting re-interview administered sub-set respondents first stage sequential survey. re-interview, relevant questions main are repeated. After introducing design and presenting theory, paper...

10.1093/jssam/smx022 article EN Journal of Survey Statistics and Methodology 2017-06-13

There is an ongoing discussion regarding the impact of adjuvant chemotherapy in Stage II colon cancer. We therefore estimated treatment effect cancer using pooled disease-free survival (DFS) data from randomized clinical trials (RCT approach) and compared this to real-world (RWD estimates. First, we RCTs by (i) searching relevant reporting DFS data, (ii) generating patient-level reported (iii) estimating data. Second, was observational cohort 1,947 patients provided Netherlands Cancer...

10.1002/ijc.32629 article EN cc-by International Journal of Cancer 2019-08-19

Objective Women with psoriatic arthritis (PsA) may have reduced tumor necrosis factor inhibitor (TNFi) effectiveness compared to men. We examined sex differences in treatment response and retention rates during 24 months of follow‐up among patients PsA initiating their first TNFi. Methods Data from across 13 European Spondyloarthritis Research Collaboration Network registries starting TNFi were pooled. Logistic regression was used analyze the association between using low disease activity...

10.1002/art.42758 article EN cc-by-nc-nd Arthritis & Rheumatology 2023-11-17

Women infected by the human papillomavirus are at an increased risk to develop cervical intraepithelial neoplasia lesions (CIN). CIN classified into three grades of increasing severity (CIN-1, CIN-2, and CIN-3) can eventually cancer. The main purpose screening is detecting CIN-2 CIN-3 cases which usually removed surgically. Screening data from POBASCAM trial involving 1454 HPV-positive women analyzed with two objectives, estimate: (a) transition time HPV diagnosis (b) CIN-3. have key...

10.1214/22-aoas1669 article EN The Annals of Applied Statistics 2023-05-01

This study aimed to explore the real-world representativeness of a prospective registry cohort with active accrual in oncology, applying metric that is novel health care.We used data from Prospective Observational Cohort Study Esophageal-Gastric Cancer Patients (POCOP) and population-based Netherlands Registry (NCR). We Representativeness-indicators (R-indicators) overall survival investigate degree which POCOP clinically relevant subgroups were representative sample compared NCR database....

10.1016/j.jclinepi.2023.10.009 article EN cc-by-nc Journal of Clinical Epidemiology 2023-10-21

In Brief Study Design. A cross-sectional study. Objective. The aim of this study was to validate the Dutch-Flemish PROMIS Pain Interference item bank in patients with musculoskeletal complaints. Summary Background Data. banks have been developed and validated US. They need be further various patient populations different languages. Methods. One thousand six hundred seventy-seven answered full bank. Graded Response Model (GRM) used dimensionality confirmatory factor analyses by assessing...

10.1097/brs.0000000000002847 article EN Spine 2018-08-16
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