A5072933348- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Hepatitis C virus research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Healthcare Systems and Technology
- Biosimilars and Bioanalytical Methods
- Gout, Hyperuricemia, Uric Acid
- Pregnancy and Medication Impact
- Lipoproteins and Cardiovascular Health
- Spondyloarthritis Studies and Treatments
- Reproductive System and Pregnancy
- Musculoskeletal Disorders and Rehabilitation
- COVID-19 Clinical Research Studies
- Chronic Disease Management Strategies
- Mental Health Treatment and Access
- Pregnancy and preeclampsia studies
- COVID-19 and healthcare impacts
- Healthcare Systems and Public Health
- Viral Infections and Immunology Research
- Tryptophan and brain disorders
- Acute Myocardial Infarction Research
- Innovations in Medical Education
- Diversity and Career in Medicine
University of Toronto
2016-2025
Sinai Health System
2017-2025
Sinai Health System
2018-2025
Mount Sinai Hospital
2010-2024
St. Michael's Hospital
2023
Toronto General Hospital
2018-2023
Diakonhjemmet Hospital
2023
University Health Network
2018-2023
Bombardier (Canada)
2023
Society of Interventional Radiology
2022
To determine whether quality of life in patients with systemic lupus erythematosus (SLE) measured by the Short Form 36 (SF-36) changes over time and which patient- disease-related factors influence such change.SLE who had > or =6 SF-36 evaluations during followup were identified from a database. Outcomes slopes scores 8 domains as well physical mental component scores. Based on direction slope, designated unchanged, improved, worsened. Linear regression models used to test contribution risk...
Epidemiologic assessments of sufficiently large populations are required in order to obtain robust estimates disease prevalence and incidence, particularly when exploring the influence various factors (age, sex, calendar time). We undertook this study describe epidemiology rheumatoid arthritis (RA) over past 15 years.We used Ontario Rheumatoid Arthritis administrative Database (ORAD), a validated population-based research database all Ontarians with RA. The ORAD records were linked census...
Objective To evaluate excess mortality over time, comparing rheumatoid arthritis (RA) patients with the general population. Methods We computed all‐cause rates among Ontario residents age ≥15 years RA versus without from 1996 to 2009. Age‐ and sex‐standardized were expressed as number of deaths per 1,000 Excess calculated difference between death those in estimated standardized ratios (SMRs) rate (MRRs) assess relative time. Results From 2009, SMRs ranged 13.0 (95% confidence interval [95%...
Objective To investigate coronavirus disease 2019 (COVID-19) hospitalization risk in patients with immune-mediated inflammatory diseases (IMIDs) compared matched non-IMID comparators from the general population. Methods We conducted a population-based, cohort study using health administrative data January to July 2020 Ontario, Canada. Cohorts for each of following IMIDs were assembled: rheumatoid arthritis (RA), psoriasis, psoriatic (PsA), ankylosing spondylitis, systemic autoimmune...
To develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA).697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008-9 consisting three separate rounds discussions modified Delphi votes. In first round 10 clinical questions were selected. A bibliographic team systematically searched Medline, Embase, Cochrane Library ACR/EULAR 2007-2008 meeting abstracts. Relevant...
Objective. To develop a list of 5 tests or treatments used in rheumatology that have evidence indicating they may be unnecessary and thus should reevaluated by healthcare providers patients. Methods. Using the Delphi method, committee 16 rheumatologists from across Canada an allied health professional generated tests, procedures, unnecessary, nonspecific, insensitive. Items with high content agreement perceived relevance advanced to survey Canadian Rheumatology Association (CRA) members. CRA...
To evaluate the risk of heart failure (HF) in patients with immune-mediated inflammatory diseases (IMIDs) compared to general population and without diabetes mellitus (DM). A population-based cohort study was conducted rheumatoid arthritis (RA), radiographic axial spondyloarthritis (r-axSpA), psoriatic arthritis, psoriasis (PsO) Ontario from 2011 until 2019. The outcome first hospitalization for HF. Incidence rates HF were calculated each cohort. Hazard ratios (HRs) using Cox proportional...
To validate a model which predicts progression from undifferentiated arthritis (UA) to RA, in Canadian UA cohort.The prediction rule, comprising variables are scored 0 13, with higher scores reflecting an increased risk of was applied baseline characteristics all patients UA. Progression RA determined at 6 months.105 were identified. By months, 80 (76%) had developed while 25 (24%) another diagnosis. Number tender and swollen joints, rheumatoid factor positivity, anti-cyclic citrullinated...
Heaf testing was carried out on 98 preschool Asian children who had received a BCG vaccination. A strongly positive reaction (grade 3) occurred in only two children. can still be used tuberculosis screening after neonatal BCG.
Abstract Objective To characterize therapies prescribed during pregnancy to women with rheumatoid arthritis (RA). Methods We conducted a cohort study of RA pregnancies using health care utilization data from 2002–2008. examined the distribution drugs by therapeutic classes, including nonsteroidal antiinflammatory (NSAIDs)/coxibs, glucocorticoids, nonbiologic disease‐modifying antirheumatic (DMARDs), and biologic DMARDs, 90‐day trimesters 180 days prior pregnancy. Drugs were characterized...
Objective. To evaluate the prevalence and predictive factors of sustained remission in an early rheumatoid arthritis (ERA) population. Predictive ERA are unknown. We hypothesized that a short time to is important predictor clinical remission. Methods. Patients Canadian Early Arthritis Cohort were included. Remission was defined by Boolean-based American College Rheumatology/European League Against Rheumatism trial practice definitions Simplified Disease Activity Index (SDAI). Logistic...
Objective. We evaluated the associations between time-varying methotrexate (MTX) use and risk of cardiovascular events (CVE) in patients with rheumatoid arthritis (RA). Methods. studied an inception cohort 23,994 RA diagnosed after their 65th birthday. Multivariable Cox regression models were fit to evaluate MTX use, controlling for other factors, time CVE. Alternative assessed cumulative duration over (1) first year, (2) previous year (recent use), (3) entire followup. also whether strength...
Rheumatology workforces are increasingly challenged by too few physicians in face of the growing burden rheumatic and musculoskeletal diseases (RMDs).Rheumatology is one most frequent non-surgical specialty referrals has longest wait times for subspecialists.We used a population-based approach to describe changes rheumatology workforce, patient volumes geographic variation supply access rheumatologists, Ontario, Canada, between 2000 2019, projected 2030.Over time, we observed greater...
Objective. To describe the frequency of remission in an early rheumatoid arthritis (ERA) cohort. Methods. The was evaluated, based on 8 definitions including Boolean-based American College Rheumatology/European League Against Rheumatism (ACR/EULAR) criteria. Results. Of 369 patients, at 12 months ranged from 18% according to ACR/EULAR clinical trial criteria 40% 28-joint Disease Activity Score (DAS28) < 2.6. Higher tender joint count, swollen and physician global scores were seen for...
Aim The objective was to examine the prevalence of atherosclerotic cardiovascular disease (ASCVD) and its risk factors among patients with RA diabetes mellitus (RA-DM) without (RAwoDM), evaluate lipid blood pressure (BP) goal attainment in RA-DM RAwoDM primary secondary prevention. Methods cohort derived from Survey Cardiovascular Disease Risk Factors Patients Rheumatoid Arthritis 53 centres/19 countries/3 continents during 2014–2019. We evaluated (CVD) RAwoDM. study population divided into...
ABSTRACT Background Although biologic treatments have excellent efficacy for many autoimmune diseases, safety concerns persist. Understanding the absolute and comparative risks of adverse events in patient disease subpopulations is critical optimal prescribing biologics. Purpose The Safety Assessment Biologic Therapy collaborative was federally funded to provide robust estimates rates relative among biologics users using data from national Medicaid Medicare plus dual‐eligible programs,...
Press releases are a popular vehicle to disseminate health information the lay media. While quality of press issued by scientific conferences and medical journals has been questioned, no efforts assess pharmaceutical industry have made. Therefore, we sought systematically examine company about original research for measures quality.Press ten top selling, international companies in year 2005 were selected evaluation. A total 1028 electronic 235 based on research. More than half (59%) reported...
Abstract Objective To describe patterns of disease‐modifying antirheumatic drug (DMARD) use during pregnancy in a population‐based cohort, and to evaluate the association between autoimmune disease, DMARDs, corticosteroids, nonsteroidal antiinflammatory drugs (NSAIDs) preeclampsia. Methods Using health care utilization databases from British Columbia (1997–2006), we compared risk for preeclampsia among 44,786 women with without disease study dispensings before (past users) first 20...