A5033549955- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Autoimmune and Inflammatory Disorders Research
- Chronic Lymphocytic Leukemia Research
- Lymphoma Diagnosis and Treatment
- Monoclonal and Polyclonal Antibodies Research
- Spondyloarthritis Studies and Treatments
- Immunodeficiency and Autoimmune Disorders
- Tuberculosis Research and Epidemiology
- Osteoarthritis Treatment and Mechanisms
- Chronic Disease Management Strategies
- Systemic Sclerosis and Related Diseases
- Health Systems, Economic Evaluations, Quality of Life
- Meta-analysis and systematic reviews
- Extracellular vesicles in disease
- Biosimilars and Bioanalytical Methods
- Advanced Biosensing Techniques and Applications
- Statistical Methods in Clinical Trials
- Advanced Causal Inference Techniques
- Immune Cell Function and Interaction
- Hepatitis C virus research
- HER2/EGFR in Cancer Research
- Cancer Immunotherapy and Biomarkers
- MicroRNA in disease regulation
- Primary Care and Health Outcomes
Diakonhjemmet Hospital
2014-2025
Medical University of Vienna
2014-2015
Brigham and Women's Hospital
2014-2015
Albany Medical Center Hospital
2015
St. Luke's International Hospital
2015
University of Massachusetts Chan Medical School
2015
New York University
2015
National Hospital Organization
2015
Center for Rheumatology
2015
New York University Langone Orthopedic Hospital
2015
To develop evidence-based recommendations on how to investigate and follow-up undifferentiated peripheral inflammatory arthritis (UPIA).697 rheumatologists from 17 countries participated in the 3E (Evidence, Expertise, Exchange) Initiative of 2008-9 consisting three separate rounds discussions modified Delphi votes. In first round 10 clinical questions were selected. A bibliographic team systematically searched Medline, Embase, Cochrane Library ACR/EULAR 2007-2008 meeting abstracts. Relevant...
Extracellular vesicles (EVs) are implicated in rheumatoid arthritis (RA) but have mainly been assessed RA patients taking disease modifying anti-rheumatic drugs. EVs nanoparticles important cell-cell communication and their molecular cargo biomarker candidates. We characterized the protein profiles of from blood plasma newly diagnosed, treatment naïve (N = 32) compared them to healthy controls 20), by size exclusion chromatography-based EV enrichment coupled with high-resolution quantitative...
Recently, new classification criteria for rheumatoid arthritis (RA) have been devised by methodology that used first a quantitative approach (data from databases), then qualitative (consensus; based on paper patients), and finally common sense-based (evaluation of the former phases). Now individual items make up these are being evaluated. This study was undertaken to analyze item "autoantibodies," in particular factor (RF) level.Three separate cohorts comprising total 972 patients with...
Abstract Extracellular vesicles (EVs) are implicated in the pathogenesis of rheumatoid arthritis (RA) but little is known about composition specific small EV (sEV) subpopulations. This study aimed to characterize CD63, CD81 and CD9 tetraspanin profile membrane single EVs plasma from treatment naïve RA patients assess potential discrepancies between methotrexate (MTX) responder groups. isolated were characterized using transmission electron microscopy, detection surface markers (CD63, CD9) on...
We wanted to assess the importance of levels anti-citrullinated peptide antibody (anti-CCP) and immunoglobulin M (IgM) rheumatoid factor (RF) in predicting development persistent arthritis from undifferentiated (UA), investigate whether there is an added predictive value for testing both anti-CCP IgM RF. Patients with UA (exclusion definite non-rheumatoid (RA) diagnoses) included Norwegian very early clinic were assessed arthritic disease. The effect level on likelihood was investigated,...
Objective. To investigate the distribution of joint involvement in a cohort patients with very recent onset arthritis and describe disease characteristics these patients. Methods. A early clinic (NOR-VEAC) was established as multicenter study. General practitioners were asked to refer presenting at least 1 swollen maximum 16 weeks’ duration. Clinical laboratory markers examined. Results. We included 634 during first 3 years, mean (25th–75th percentile) duration 30 (11–63) days. Monoarthritis...
Background: Differences in DNA methylation have been reported B and T lymphocyte populations, including CD4+ cells, isolated from rheumatoid arthritis (RA) patients when compared to healthy controls. cells are a heterogeneous cell type with subpopulations displaying distinct patterns. In this study, we investigated using reduced representation bisulfite sequencing two populations (CD4+ memory naïve cells) three groups: newly diagnosed, disease modifying antirheumatic drugs (DMARD) RA (N =...
The aim of the study was to assess RF cross-reactivity animal antibodies used in immunoassays, and test if selected commercial immunoassays are vulnerable interference from RF, causing false results. Our included samples patients with RF-positive rheumatoid arthritis (RA) controls (patients RF-negative RA psoriatic arthritis), an early arthritis-cohort. Reactivity mouse IgG1, IgG2a, rabbit IgG, bovine sheep/goat IgG human analysed using in-house assays. sera strong reactivity IgG1 were three...
Objective. Presence and levels of antibodies contribute to the classification rheumatoid arthritis. We investigated longitudinal course anti-citrullinated protein (ACPA) immunoglobin M (IgM) factor (RF) during first year after arthritis onset in patients with very short disease duration. Methods. Patients (aged 18–75 years) ≥ 1 swollen joint ≤ 16 weeks’ duration had assessments ACPA (2nd generation anti-cyclic citrullinated peptide antibodies, anti-CCP2) IgM RF at inclusion 3, 6, 12 months....
Abstract Introduction The current 1987 American College of Rheumatology (ACR) classification criteria for rheumatoid arthritis (RA) have proven less useful in early arthritis. objective this study was to identify and compare predictors three relevant outcomes chronic a cohort very patients. Methods Norwegian Very Early Arthritis Cohort (NOR-VEAC) includes adult patients with at least one swollen joint ≤16 weeks' duration. Patients are followed 2 years comprehensive clinical laboratory...
Objective. We conducted a longitudinal observational study of biological disease-modifying antirheumatic drugs (bDMARD) to describe the proportions patients with rheumatoid arthritis in remission who discontinued these agents, and assess potential predictors decision discontinue. Methods. used data from US COnsortium Rheumatology Researchers Of North America (CORRONA) Japanese National Database Rheumatic Diseases by iR-net Japan (NinJa) registries, ran parallel analyses. Patients treated...
Background Methotrexate (MTX) is the first line treatment of rheumatoid arthritis (RA), and methylation changes in bulk T cells have been reported after with MTX. We investigated cell-type specific DNA across genome naïve memory CD4 + before MTX RA patients. profiles newly diagnosed patients (N=9) were assessed by reduced representation bisulfite sequencing. Results found that significantly influenced levels at multiple CpG sites both cell populations. Interestingly, we identified...
Rheumatoid arthritis (RA) is a complex disease with wide range of underlying susceptibility factors. Recently, dysregulation microRNAs (miRNAs) in RA have been reported several immune cell types from blood. However, B cells not studied detail yet. Given the autoimmune nature presence autoantibodies, CD19+ are key type pathogenesis and alterations subpopulations observed patient Therefore, we aimed to reveal global miRNA repertoire analyze expression profile differences homogenous phenotypes...
Objective The objective of this study was to compare achievement remission in 2 early rheumatoid arthritis ( RA ) treat‐to‐target TTT cohorts, a tight control cohort with target stringent randomized controlled trial and an observational targeting looser definition clinical practice. Methods We analyzed data from the Aiming for Remission Rheumatoid Arthritis: randomised examining benefit ultrasound Clinical Tight Control regimen ARCTIC Norwegian Very Early Arthritis Clinic NOR ‐ VEAC study....
Objective. To examine the 2-year disease course in patients with undifferentiated arthritis (UA) focusing on fulfillment of 2010 American College Rheumatology/European League Against Rheumatism (ACR/EULAR) rheumatoid (RA) classification criteria. Methods. Data were provided by Norwegian Very Early Arthritis Clinic study, which included presenting ≥ 1 swollen joint ≤ 16 weeks’ duration. UA was defined as not fulfilling ACR/EULAR RA criteria and who did have a clinical diagnosis other than at...
Objective. Current recommendations advocate treatment with disease-modifying antirheumatic drugs (DMARD) in all patients active rheumatoid arthritis (RA). We investigated the frequency of and reasons for inconsistent DMARD use among a clinical rheumatology cohort. Methods. Patients Brigham Rheumatoid Arthritis Sequential Study were studied (any or none) at each semiannual study timepoint during first 2 years. Inconsistent was defined as ≤ 40% timepoints. Characteristics compared between...
Objective To determine how the European League Against Rheumatism (EULAR) definition of erosive disease (erosion criterion) contributes to number patients classified as rheumatoid arthritis (RA) according 2010 American College Rheumatology/EULAR RA classification criteria (2010 criteria) in an early cohort. Methods Patients from observational study Norwegian Very Early Arthritis Clinic with joint swelling ≤16 weeks, a clinical diagnosis or undifferentiated arthritis, and radiographs hands...
To describe the diagnostic spectrum, arthritis persistency and clinical outcomes after 2 years in patients with inflammatory (IA) of less than 16 weeks' duration. Data from Norwegian Very Early Arthritis Clinic, a 2-year longitudinal observational study adults IA ≤16 duration, were used. Exclusion criteria due to crystal deposits, trauma, osteoarthritis septic arthritis. In all who had any follow-up information (population A), diagnoses described. For B), we also studied other (disease...
Objective The present study was undertaken to investigate the joint distribution and 2‐year outcome of patients with recent‐onset monoarthritis. Methods Adult clinically apparent monoarthritis ≤16 weeks’ duration were included in a multicenter longitudinal study. Clinical characteristics, distribution, development chronic inflammatory rheumatic disease (CIRD), as well classification criteria according American College Rheumatology (ACR)/European League Against Rheumatism (EULAR) 2010 for RA...