A5102851409- Rheumatoid Arthritis Research and Therapies
- Systemic Lupus Erythematosus Research
- Systemic Sclerosis and Related Diseases
- Monoclonal and Polyclonal Antibodies Research
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Hemophilia Treatment and Research
- Pregnancy and Medication Impact
- Lymphoma Diagnosis and Treatment
- T-cell and B-cell Immunology
- Osteoarthritis Treatment and Mechanisms
- Immunodeficiency and Autoimmune Disorders
- Chronic Lymphocytic Leukemia Research
- Orthopedic Infections and Treatments
- Chronic Myeloid Leukemia Treatments
- CAR-T cell therapy research
- Pregnancy and preeclampsia studies
- Inflammatory Myopathies and Dermatomyositis
- Toxin Mechanisms and Immunotoxins
- Drug-Induced Adverse Reactions
- Cell Adhesion Molecules Research
- Skin Protection and Aging
- Cardiovascular Function and Risk Factors
- Dupuytren's Contracture and Treatments
- Brain Metastases and Treatment
- Cytokine Signaling Pathways and Interactions
University Medical Center Utrecht
2014-2024
Wikimedia Nederland
2018
Utrecht University
2016
Center for Rheumatology
2015
Newcastle University
2009
Leiden University
1990-2009
Leiden University Medical Center
2005-2009
The presence of activated T cells in the synovial membrane patients with rheumatoid arthritis (RA) suggests a role for these pathogenesis disease, Recent evidence indicates that human may fall into functional categories dependent on their cytokine profile and cytotoxic capacity. Th 1 subset is cytolytic produces high levels IFN–gamma whereas Th2 type cell IL–4. In order to investigate whether or 2 are present inflammatory RA. panel derived T–cell clones ( n =19) was generated studied...
Evaluation whether biomarkers of joint damage are sensitive to change shortly after a bleed in hemophilia patients and canine model blood-induced damage.Blood urine samples were collected from 10 they reported bleed: within 2 days, 3-5 12-14 days. Additionally, 90 days the blood sample was taken considered represent baseline condition. Commercial serum biomarker assays performed: urinary C-terminal telopeptide type II collagen (uCTX-II), cartilage oligomeric matrix protein (sCOMP), cleavage...
Objective . To investigate the effect of hydroxychloroquine (HCQ) in pregnant women with systemic lupus erythematosus (SLE). Methods In SLE pregnancies a single Dutch center (2000–2015), activity and flares before during pregnancy postpartum were assessed using Disease Activity Index (SLEDAI)/SLEPDAI (SLEDAI adjusted for pregnancy). The association between HCQ use outcomes (early spontaneous abortion, fetal death, preterm term live birth) was analyzed generalized estimating equations (GEE)...
Connective tissue disease associated interstitial lung (CTD-ILD) is with decreased quality of life and high mortality risk. Outcome treatment response unpredictable. This study aimed to identify clinical predictors for CTD-ILD poor outcome.We performed a retrospective single centre cohort in outpatients seen between 2004 2018. Clinical biochemical data, pulmonary function tests (PFT) high-resolution computed tomography (HRCT) results were analysed. Overall survival progressive fibrosing ILD...
An abnormal CD4+ T cell subset related to inflammation exposure (inflammation-related cells, IRC) has been identified in rheumatoid arthritis (RA). Patients with inflammatory and non-inflammatory diseases were used examine the relationship between this vivo.Blood was collected from healthy controls patients RA (active disease or clinical remission), Crohn's osteoarthritis. IRC chemokine receptors quantified by flow cytometry. Thymic activity apoptotic factors measured real-time polymerase...
Objective . To investigate disease activity around and during pregnancy outcome in women with systemic lupus erythematosus (SLE) considering antiphospholipid antibody status. Moreover, differences between first consecutive pregnancies were examined. Methods Pregnancies > 16 weeks gestation of SLE patients receiving joint care from rheumatologists gynecologists two tertiary centers the Netherlands 2000 2015 included. Disease activity, flare rate, outcomes complications assessed. Results...
Connective tissue diseases-associated interstitial lung disease (CTD-ILD) is a heterogeneous condition that impairs quality of life and associated with premature death. Progressive pulmonary fibrosis (PPF) has been identified as an important risk factor for poor prognosis. However, different criteria PPF are used in clinical studies, which may complicate comparison between trials translation study findings into practice.This retrospective single center patients CTD-ILD. The prognostic...
The dominant presence of specific T-cell populations in the rheumatoid joint as detected by Southern blot analysis T cell receptor (TCR) gene rearrangements would indicate local antigen recognition and proliferation. We therefore studied TCR beta chain using a C 2 probe paired samples from synovial tissue peripheral blood (n = 6) well fluid 16) 18) patients with arthritis (RA). Peripheral mononuclear cells healthy donors 7) served control. were directly after isolation or non-specific...
Paired synovial fluid (SF) samples obtained from the knees of 12 arthritis patients were studied to establish a relation between parameters local inflammatory activity and SF interleukin—6 (IL—6) levels. Local disease was scored using joint temperature, swelling pain as clinical inflammation. assayed for laboratory inflammation such leucocyte content, percentage polymorphonuclear cells, pH, immu—noglobulin levels (IgG, IgM). IL—6 concentrations determined B9—bioassay. Within individual...
Autoantigen-specific immunotherapy by mucosal tolerance induction via the intranasal route is an attractive therapeutic option for treatment of autoimmune diseases, including rheumatoid arthritis (RA). Human cartilage glycoprotein-39 (HC gp-39) has been identified as a potential key autoantigen in RA. Based on animal studies, administration hypothesised to induce immunological patients with RA and ameliorate disease activity. In phase I/IIA clinical trial RA, application HC gp-39 was safe...
PURPOSE: To detect abnormalities in cardiac function by using magnetic resonance (MR) imaging patients with mild to moderate pulmonary fibrosis and evaluate the relationship between function. MATERIALS AND METHODS: Sixteen were compared 16 sex- age-matched healthy control subjects. Systolic was assessed multisection multiphase cine MR imaging. Diastolic flow-sensitive across mitral tricuspid valves. results severity of impairment RESULTS: Biventricular systolic left ventricular diastolic...
Objectives: To gain insight into the experiences of patients with diffuse cutaneous systemic sclerosis during and after autologous hematopoietic stem cell transplantation. Methods: Semi-structured interviews were conducted who underwent transplantation in four university hospitals Netherlands. Interviews transcribed verbatim thematically analyzed. Results: Nine male seven female interviewed, median age 47 years (range: 27–68). Patients mentioned their life was severely disrupted before...
Cellular senescence and endothelial-to-mesenchymal transition (EndMT) are profibrotic cellular processes involved in systemic sclerosis (SSc), but how they respond to treatment is largely unknown.
Objectives To compare computerised and conventional methodology of radiographic joint destruction assessment in early rheumatoid arthritis (RA). Methods We investigated the contribution 3rd-to-5th carpometacarpal joints (CMC3-5, which are excluded so far owing to bone overlapping) total space narrowing (JSN) scores two cohorts patients with RA (n=392). Next, we agreement between JSN scoring using single time point individual joint-based method (individual a (IJSTP), reflecting reading)...
Positron emission tomography (PET) is a promising technique to improve the assessment of systemic sclerosis associated interstitial lung disease (SSc-ILD). This could be particular value in patients with severe diffuse cutaneous SSc (dcSSc) that are possibly eligible for autologous hematopoietic stem cell transplantation (aHSCT). aHSCT potentially effective therapy dcSSc and ILD, leading stabilization or improvement function. However, there high need patient selection, which includes (1)...
<h3>Background:</h3> Autologous hematopoietic stem cell transplantation (HSCT) has shown superior efficacy to cyclophosphamide pulse therapy in systemic sclerosis (SSc) but its application is hampered by high treatment related mortality (TRM). To date factors, other than smoking, predicting TRM are unknown. <h3>Objectives:</h3> describe event-free survival and after HSCT evaluate the predictive value of baseline characteristics. Event-free was defined as absence or major organ failure (i.e....