A5022871817- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Knee injuries and reconstruction techniques
- Inflammatory mediators and NSAID effects
- Hemophilia Treatment and Research
- Bone fractures and treatments
- Rheumatoid Arthritis Research and Therapies
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Lower Extremity Biomechanics and Pathologies
- Neurogenetic and Muscular Disorders Research
- Blood Coagulation and Thrombosis Mechanisms
- Medical and Biological Sciences
- Veterinary Orthopedics and Neurology
- Orthopedic Infections and Treatments
- Orthopaedic implants and arthroplasty
- Connective tissue disorders research
- Bone and Joint Diseases
- Chronic Myeloid Leukemia Treatments
- Platelet Disorders and Treatments
- Coagulation, Bradykinin, Polyphosphates, and Angioedema
- Pain Mechanisms and Treatments
- Bone Metabolism and Diseases
- Adipokines, Inflammation, and Metabolic Diseases
- Neuropeptides and Animal Physiology
- Tendon Structure and Treatment
Utrecht University
2016-2025
University Medical Center Utrecht
2016-2025
Heidelberg University
2016-2024
University Hospital Heidelberg
2016-2024
Harvard University
2024
Center for Rheumatology
2013-2018
University of Twente
2011
University of Georgia
2011
University of Groningen
2007
University Medical Center
2007
<h3>Background</h3> Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than replacement. <h3>Objectives</h3> To examine whether distraction can effectively modify and has the potential to delay prosthesis surgery. <h3>Methods</h3> 20 patients (<60 years) with tibiofemoral were treated surgically using distraction. Distraction (∼5 mm) was applied 2 months an external fixation frame. Tissue...
Abstract Background This study evaluates changes in peri-articular bone two canine models for osteoarthritis: the groove model and anterior cruciate ligament transection (ACLT) model. Methods Evaluation was performed at 10 20 weeks post-surgery addition a 3-weeks time point studied Cartilage analysed, architecture of subchondral plate trabecular epiphyses quantified using micro-CT. Results At cartilage histology biochemistry demonstrated characteristic features osteoarthritis both (very mild...
Both, knee joint distraction as a relatively new approach and valgus-producing opening-wedge high tibial osteotomy (HTO), are knee-preserving treatments for osteoarthritis (OA). The efficacy of compared to HTO has not been reported. Sixty-nine patients with medial OA varus axis deviation <10° were randomized either (n = 23) or 46). Questionnaires assessed at baseline 3, 6, 12 months. Joint space width (JSW) surrogate measure cartilage thickness was determined on standardized semi-flexed...
Pain is the major debilitating symptom of osteoarthritis (OA), which difficult to treat. In OA patients joint tissue damage only poorly associates with pain, indicating other mechanisms contribute pain. Immune cells regulate sensory system, but little known about involvement immune in Here, we report that macrophages accumulate dorsal root ganglia (DRG) distant from site injury two rodent models OA. DRG acquired an M1-like phenotype, and depletion resolved pain male female mice. Sensory...
Knee joint distraction (KJD) is a novel, but poorly understood, treatment for osteoarthritis (OA) associated with remarkable 'spontaneous' cartilage repair in which resident synovial fluid (SF) multipotential mesenchymal stromal cells (MSCs) may play role. We hypothesised that SF hyaluronic acid (HA) inhibited the initial interaction between MSCs and cartilage, key first step to integration, postulate KJD environment favoured MSC/cartilage interactions.Attachment of dual-labelled SF-MSCs...
Objective In end-stage knee osteoarthritis, total arthroplasty (TKA) may finally become inevitable. At a relatively young age, this comes with the risk of future revision surgery. Therefore, in these cases, joint preserving surgery such as distraction (KJD) is preferred. Here we present 5-year follow-up data KJD. Design Patients ( n = 20; age <60 years) conservative therapy resistant tibiofemoral osteoarthritis considered for TKA were treated. Clinical evaluation was performed by...
Both, knee joint distraction (KJD) and high tibial osteotomy (HTO) are joint-preserving surgeries that postpone total arthroplasty (TKA) in younger osteoarthritis (OA) patients. Here we evaluate the 2-year follow-up of KJD versus TKA HTO 2 noninferiority studies.Knee OA patients indicated for were randomized to (n = 20; KJDTKA) or 40). Medial compartmental considered 23; KJDHTO) 46). Patient-reported outcome measures assessed over years follow-up. The radiographic space width (JSW) was...
Abstract In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of changes in OA are still unclear. architecture damage were compared differently induced experimental models OA. Experimental was bilaterally anterior cruciate ligament transection (ACLT) or trauma (Groove model); bilateral sham surgery served as control. Lysylpyridinoline (LP, resorption) C-telopeptide type II collagen (CTX-II, breakdown) measured over time. At...
Evaluation whether biomarkers of joint damage are sensitive to change shortly after a bleed in hemophilia patients and canine model blood-induced damage.Blood urine samples were collected from 10 they reported bleed: within 2 days, 3-5 12-14 days. Additionally, 90 days the blood sample was taken considered represent baseline condition. Commercial serum biomarker assays performed: urinary C-terminal telopeptide type II collagen (uCTX-II), cartilage oligomeric matrix protein (sCOMP), cleavage...
Knee osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage, bone, and synovial tissue changes that lead to pain functional impairment. Joint distraction treatment provides long-term improvement in function accompanied cartilage repair, as evaluated indirectly imaging studies measurement of biochemical markers. The purpose this study was evaluate repair directly histologic assessments after treatment.In 27 dogs, OA induced the right knee (groove model; surgical...
Aims Knee joint distraction (KJD) is a relatively new, knee-joint preserving procedure with the goal of delaying total knee arthroplasty (TKA) in young and middle-aged patients. We present randomised controlled trial comparing two. Patients Methods The 60 patients ≤ 65 years end-stage osteoarthritis were to either KJD (n = 20) or TKA 40). Outcomes assessed at baseline, three, six, nine, 12 months. In group, space width (JSW) was radiologically assessed, representing surrogate marker...
Background: Osteochondritis dissecans (OCD) of the knee is a rare but potentially incapacitating disorder in which subchondral bone detaches, leading to an osteochondral fragment that can become unstable and progress into loose body. The exact cause unknown, although several biological mechanical factors have been described. Purpose: To provide insight epidemiological data large cohort patients affected by OCD identify potential contributing this disorder. Study Design: Cross-sectional...
Abstract Objective To determine the association between joint structure and gait in patients with knee osteoarthritis (OA). Methods IMI-APPROACH recruited 297 clinical OA patients. Gait data was collected (GaitSmart®) OA-related measures determined from radiographs (KIDA) MRIs (qMRI/MOAKS). Patients were divided into those with/without radiographic (ROA). Principal component analyses (PCA) performed on parameters; linear regression models used to evaluate whether image-based structural...