A5004430213- Medical and Biological Sciences
- Osteoarthritis Treatment and Mechanisms
- Knee injuries and reconstruction techniques
- Total Knee Arthroplasty Outcomes
- Musculoskeletal Disorders and Rehabilitation
- Veterinary Orthopedics and Neurology
- Neurogenetic and Muscular Disorders Research
- Radiopharmaceutical Chemistry and Applications
- Hematological disorders and diagnostics
- Bone fractures and treatments
- Prostate Cancer Diagnosis and Treatment
- Orthopedic Surgery and Rehabilitation
- Hip and Femur Fractures
- Lower Extremity Biomechanics and Pathologies
- Cardiovascular Disease and Adiposity
- Cell Adhesion Molecules Research
- Foot and Ankle Surgery
- Cardiac, Anesthesia and Surgical Outcomes
- Oral Health Pathology and Treatment
- Hip disorders and treatments
- Osteomyelitis and Bone Disorders Research
- Cardiac Imaging and Diagnostics
- Medical Practices and Rehabilitation
- Tendon Structure and Treatment
- Prostate Cancer Treatment and Research
Meander Medisch Centrum
2020
University Medical Center Utrecht
2006-2016
University of Applied Sciences Utrecht
2014
Utrecht University
2010
<h3>Background</h3> Modification of joint tissue damage is challenging in late-stage osteoarthritis (OA). Few options are available for treating end-stage knee OA other than replacement. <h3>Objectives</h3> To examine whether distraction can effectively modify and has the potential to delay prosthesis surgery. <h3>Methods</h3> 20 patients (<60 years) with tibiofemoral were treated surgically using distraction. Distraction (∼5 mm) was applied 2 months an external fixation frame. Tissue...
Abstract Background This study evaluates changes in peri-articular bone two canine models for osteoarthritis: the groove model and anterior cruciate ligament transection (ACLT) model. Methods Evaluation was performed at 10 20 weeks post-surgery addition a 3-weeks time point studied Cartilage analysed, architecture of subchondral plate trabecular epiphyses quantified using micro-CT. Results At cartilage histology biochemistry demonstrated characteristic features osteoarthritis both (very mild...
Objective In end-stage knee osteoarthritis, total arthroplasty (TKA) may finally become inevitable. At a relatively young age, this comes with the risk of future revision surgery. Therefore, in these cases, joint preserving surgery such as distraction (KJD) is preferred. Here we present 5-year follow-up data KJD. Design Patients ( n = 20; age <60 years) conservative therapy resistant tibiofemoral osteoarthritis considered for TKA were treated. Clinical evaluation was performed by...
Abstract In osteoarthritis (OA), cartilage degradation is accompanied by subchondral bone changes. The pathogenesis and physiology of changes in OA are still unclear. architecture damage were compared differently induced experimental models OA. Experimental was bilaterally anterior cruciate ligament transection (ACLT) or trauma (Groove model); bilateral sham surgery served as control. Lysylpyridinoline (LP, resorption) C-telopeptide type II collagen (CTX-II, breakdown) measured over time. At...
Knee osteoarthritis (OA) is a degenerative joint disorder characterized by cartilage, bone, and synovial tissue changes that lead to pain functional impairment. Joint distraction treatment provides long-term improvement in function accompanied cartilage repair, as evaluated indirectly imaging studies measurement of biochemical markers. The purpose this study was evaluate repair directly histologic assessments after treatment.In 27 dogs, OA induced the right knee (groove model; surgical...
In studies aimed at local treatment of experimental osteoarthritis (OA) it is optimal to have an internal (untreated) OA control. Such approach excludes interanimal variation, and allows paired statistical evaluation efficacy. For this purpose, we developed characterized a bilateral version the canine Groove model. We hypothesized that model would show consistent clear development features similar those found in unilateral version. six Beagle dogs, grooves were surgically made articular...
The value of experimental models osteoarthritis (OA) largely depends on the ability to translate observations human OA. Surprisingly, direct comparison characteristics and OA is scarce. In present study, cartilage integrity matrix turnover in a canine model joint degeneration were compared clinical 23 Beagle dogs, was induced one knee, contra-lateral knee served as control. For comparison, osteoarthritic healthy obtained at arthroplasty (n=14) post-mortem (n=13). Cartilage analyzed by...