A5022618012- Hormonal Regulation and Hypertension
- Stress Responses and Cortisol
- Estrogen and related hormone effects
- Growth Hormone and Insulin-like Growth Factors
- Pituitary Gland Disorders and Treatments
- Adipokines, Inflammation, and Metabolic Diseases
- Adrenal Hormones and Disorders
- Liver Disease Diagnosis and Treatment
- Adipose Tissue and Metabolism
- Cancer, Hypoxia, and Metabolism
- Blood properties and coagulation
- Endoplasmic Reticulum Stress and Disease
- Erythrocyte Function and Pathophysiology
- Blood Coagulation and Thrombosis Mechanisms
- Sex and Gender in Healthcare
- Cancer Treatment and Pharmacology
- Erythropoietin and Anemia Treatment
- Trauma, Hemostasis, Coagulopathy, Resuscitation
- Receptor Mechanisms and Signaling
- Retinal Diseases and Treatments
- Immune Response and Inflammation
- Traumatic Brain Injury and Neurovascular Disturbances
- Neonatal and Maternal Infections
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- GDF15 and Related Biomarkers
Louisiana State University Health Sciences Center Shreveport
2017-2023
Louisiana State University
2023
University of Notre Dame
2006-2020
National Institute of Environmental Health Sciences
2012-2017
Triangle
2015-2017
National Institutes of Health
2012-2016
In The Meantime Men’s Group
2015
Ohio University
2010-2012
Biotechnology Institute
2010-2011
Aarhus University Hospital
2011
Glucocorticoids and their synthetic derivatives are known to alter cardiac function in vivo; however, the nature of these effects whether glucocorticoids act directly on cardiomyocytes poorly understood. To explore role glucocorticoid signaling heart, we used rat embryonic H9C2 primary as model systems. Dexamethasone (100 nm) treatment caused a significant increase cell size up-regulated expression hypertrophic markers, including atrial natriuretic factor, β-myosin heavy chain, skeletal...
Significance Stress is increasingly associated with heart disease. Glucocorticoids are primary stress hormones, yet their direct role in the poorly understood. Mice lacking glucocorticoid receptor specifically cardiomyocytes die prematurely from failure. The deficiency signaling leads to aberrant regulation of a large cohort genes strongly both cardiovascular and inflammatory disease processes. These findings reveal an obligate for cardiomyocyte receptors maintaining normal function define paradigm
While in vitro studies have demonstrated that a glucocorticoid receptor (GR) splice isoform, β-isoform of human GR (hGRβ), acts as dominant-negative inhibitor the classic hGRα and confers resistance, vivo function hGRβ is poorly understood. To this end, we created an adeno-associated virus (AAV) to express mouse liver under control hepatocyte-specific promoter. Genome-wide expression analysis livers showed significantly increased numerous genes, many which are involved endocrine system...
Activation of the hypothalamic-pituitary-adrenal axis results in release hormones from adrenal glands, including glucocorticoids and mineralocorticoids. The physiological association between corticosteroids cardiac disease is becoming increasingly recognized; however, mechanisms underlying this are not well understood. To determine biological effects on heart, we investigated impact adrenalectomy C57BL/6 male mice. Animals were adrenalectomized (ADX) at 1 month age maintained for 3–6 months...
Background The contribution of glucocorticoids to sexual dimorphism in the heart is essentially unknown. Therefore, we sought determine sexually dimorphic actions glucocorticoid signaling cardiac function and gene expression. To accomplish this goal, conducted studies on mice lacking receptors (GR) cardiomyocytes (cardioGRKO mouse model). Methods Results Deletion cardiomyocyte GR leads an increase mortality because development spontaneous pathology both male female mice; however, females are...
Context Transsphenoidal adenomectomy is the primary treatment for acromegaly. However, assessment of therapeutical outcome remains problematic since existing biomarkers disease activity frequently show discordant results. Objective To discover novel serum in acromegalic patients before and after surgery. Design Serum samples eight newly diagnosed acromegaly transsphenoidal surgery were analyzed proteomic changes by two-dimensional gel electrophoresis. Protein spots displaying statistically...
Erythropoietin (Epo) is produced primarily in the kidneys upon low blood oxygen availability and stimulates erythropoiesis bone marrow. Recombinant human Epo (rHuEpo), a drug developed to increase arterial content patients, also illicitly used by athletes improve their endurance performance. Therefore, robust sensitive test detect its abuse needed. The aim of present study was investigate potential serum biomarkers employing proteomic approach. Eight healthy male subjects were injected...
GH secretion peaks at puberty and continues to be secreted in adulthood, albeit a declining rate. Profound deficiency (GHD) adults with pituitary disease is associated symptoms that improve substitution, but it important tailor the dose avoid overtreatment. Measurement of serum IGF-I levels an clinical tool this regard, well recognized some patients receiving treatment do not show increase IGF-I.The objective study was identify novel biomarkers GHD.Eight profound GHD as consequence adenoma...
Nonalcoholic fatty liver disease (NAFLD) is one of the most prevalent forms chronic in United States and worldwide. steatohepatitis (NASH), advanced form NAFLD, characterized by hepatic steatosis associated with inflammation hepatocyte death. No treatments are currently available for NASH other than lifestyle changes, lacks specific biomarkers. The signaling lymphocytic activation molecule family 1 (SLAMF1) protein a self-ligand receptor that plays role orchestrating an immune response to...
Abstract Severe inflammation leads to haemostatic abnormalities, such as the development of microvascular thrombi. As a result, ischaemia‐related downstream organ damage can occur. The present study demonstrates that mice with total deficiency fibrinogen ( Fg −/− ) altered responses challenge Gram‐negative lipopolysaccharide (LPS). Early survival in response continuous LPS was increased and histological findings indicated this improvement correlated lack fibrin deposition organs. Neutrophils...
Mental stress is a risk factor for myocardial infarction in women. The central hypothesis of this study that restraint induces sex-specific changes gene expression the heart, which leads to an intensified response ischemia/reperfusion injury due development pro-oxidative environment female hearts. We challenged male and C57BL/6 mice model mimic effects mental stress. Exposure led sex differences genes involved cardiac hypertrophy, inflammation, iron-dependent cell death (ferroptosis). Among...