A5028646111- Sulfur Compounds in Biology
- Nitric Oxide and Endothelin Effects
- Neuroscience of respiration and sleep
- Eicosanoids and Hypertension Pharmacology
- Cancer, Hypoxia, and Metabolism
- Angiogenesis and VEGF in Cancer
- Alcohol Consumption and Health Effects
- Mitochondrial Function and Pathology
- Obstructive Sleep Apnea Research
- ATP Synthase and ATPases Research
- Hydrogen's biological and therapeutic effects
- Advanced Chemical Sensor Technologies
- Mast cells and histamine
- High Altitude and Hypoxia
- Atherosclerosis and Cardiovascular Diseases
- Nuclear Receptors and Signaling
- Ferroptosis and cancer prognosis
- Air Quality and Health Impacts
- Peripheral Artery Disease Management
- Metabolomics and Mass Spectrometry Studies
- Cerebrovascular and Carotid Artery Diseases
- Asthma and respiratory diseases
- Adenosine and Purinergic Signaling
- MicroRNA in disease regulation
- Adipose Tissue and Metabolism
Louisiana State University Health Sciences Center Shreveport
2016-2025
Louisiana State University Health Sciences Center New Orleans
2011-2022
Louisiana State University in Shreveport
2016
Louisiana State University
2010-2014
Jilin University
2011
The University of Texas Health Science Center at San Antonio
2011
Stanford University
2011
VA Palo Alto Health Care System
2011
The Ohio State University
2011
Abstract The use of natural substance to ward off microbial infections has a long history. However, the large-scale production extracts often reduces antibacterial potency, thus limiting practical applications. Here we present strategy for converting organosulfur compounds into nano-iron sulfides that exhibit enhanced activity. We show compared garlic-derived an over 500-fold increase in efficacy kill several pathogenic and drug-resistant bacteria. Furthermore, our analysis reveals hydrogen...
Background Hydrogen sulfide (H 2 S) therapy is recognized as a modulator of vascular function during tissue ischemia with the notion potential interactions nitric oxide ( NO ) metabolism. However, little known about specific biochemical mechanisms or importance H S activation metabolism ischemic remodeling. The goal this study was to determine effect on chronic and subsequent effects remodeling responses. Methods Results unilateral, permanent femoral artery ligation model hind‐limb performed...
Abstract The mammalian brain is highly vulnerable to oxygen deprivation, yet the mechanism underlying brain’s sensitivity hypoxia incompletely understood. Hypoxia induces accumulation of hydrogen sulfide, a gas that inhibits mitochondrial respiration. Here, we show that, in mice, rats, and naturally hypoxia-tolerant ground squirrels, inversely related levels sulfide:quinone oxidoreductase (SQOR) capacity catabolize sulfide. Silencing SQOR increased hypoxia, whereas neuron-specific expression...
Hydrogen sulfide has emerged as an important gaseous signaling molecule and a regulator of critical biological processes. However, the physiological significance hydrogen metabolites such persulfides, polysulfides, other reactive sulfur species (RSS) only recently been appreciated. Emerging evidence suggests that these RSS molecules may have similar or divergent regulatory roles compared with in various activities. chemical nature persulfides polysulfides is complex remains poorly understood...
Background Hydrogen sulfide (H 2 S) has been implicated in regulating cardiovascular pathophysiology experimental models. However, there is a paucity of information regarding the levels H S health and disease. In this study we examine patients with disease as well bioavailability nitric oxide inflammatory indicators. Methods Results Patients over age 40 undergoing coronary or peripheral angiography were enrolled study. Ankle brachial index ( ABI ) measurement, measurement plasma‐free total...
The family of gasotransmitter molecules, nitric oxide (NO), carbon monoxide (CO), and hydrogen sulfide (H2S), has emerged as an important mediator numerous cellular signal transduction pathophysiological responses. As such, these molecules have been reported to influence a diverse array biochemical, molecular, cell biology events often impacting one another. Recent Advances: Discrete regulation molecule formation, movement, reaction is critical their biological function. Due the chemical...
Aims: Hydrogen sulfide (H2S) is a vasoactive gasotransmitter that endogenously produced in the vasculature by enzyme cystathionine γ-lyase (CSE).However, importance of CSE activity and local H2S generation for ischemic vascular remodeling remains completely unknown.In this study, we examine hypothesis critically regulates involving dependent mononuclear cell regulation arteriogenesis.Methods results: Arteriogenesis including mature vessel density, collateral formation; blood flow SPY...
Hydrogen sulfide (H2S) is an important gaseous signaling molecule in the cardiovascular system. In addition to free H2S, H2S can be oxidized polysulfide which biologically active. Since impact of on endothelial solute barrier function not known, we sought determine whether and its various metabolites affect permeability. vitro permeability was evaluated using albumin flux transendothelial electrical resistance. Different donors were used examine effects exogenous H2S. To evaluate role...
Endothelial dysfunction is a critical, initiating step in the development of hypertension (HTN) and mitochondrial reactive oxygen species (ROS) are important contributors to endothelial dysfunction. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) nicotinamide transhydrogenase (Nnt) gene that associated with increased risk for HTN. NNT emerging as an enzyme regulates NADPH levels redox balance by supporting thiol dependent peroxidase systems...
Background/Objectives: Hydrogen sulfide (H2S) is a vasorelaxant gas and exerts anti-oxidative, anti-inflammatory, cytoprotective effects. H2S has been implicated in regulating placental vaso-activity angiogenesis. It believed that abnormal trophoblast production of vasodilators angiogenic factors contributes to pre-eclampsia development. However, little known about whether aberrant present trophoblasts from pre-eclamptic pregnancies. Methods: Trophoblasts were isolated normal placentas....
Nitrite anion has been demonstrated to be a prodrug of nitric oxide (NO) with positive effects on tissue ischemia/reperfusion injury, cytoprotection, and vasodilation. However, nitrite therapy for ischemic vascular remodeling during diabetes remain unknown. We examined whether sodium altered revascularization in BKS-Leprdb/db mice subjected permanent unilateral femoral artery ligation. Sodium completely restored hind limb blood flow compared nitrate or PBS therapy. Importantly, delayed 5...
Hydrogen sulfide (H2S) has emerged as an important physiological and pathophysiological signaling molecule in the cardiovascular system influencing vascular tone, cytoprotective responses, redox reactions, adaptation, mitochondrial respiration. However, bioavailable levels of H2S its various biochemical metabolite forms during clinical disease remain poorly understood. We performed a case-controlled study to quantify compare bioavailability patients with without (CVD). In our study, we used...
Withaferin A (WA), a natural product derived from Withania somnifera, has been used in traditional oriental medicines to treat neurological disorders. Recent studies have demonstrated that this compound may potential for cancer treatment and clinical trial launched test WA treating melanoma. Herein, WA's chemopreventive was tested chemically-induced skin carcinogenesis mouse model. Pathological examinations revealed significantly suppressed tumor formation. Morphological observations of the...
Insufficient hydrogen sulfide (H2S) has been implicated in Type 2 diabetic mellitus (T2DM) and hyperhomocysteinemia (HHcy)-related cardiovascular complications. We investigated the role of H2S T2DM HHcy-induced endothelial dysfunction small mesenteric artery (SMA) db/db mice fed a high methionine (HM) diet. HM diet (8 weeks) induced HHcy both non-diabetic db/+ (total plasma Hcy: 48.4 31.3 µM, respectively), aggravated impaired endothelium-derived hyperpolarization factor (EDHF)-induced...