A5042791450- Head and Neck Cancer Studies
- Salivary Gland Tumors Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Ear and Head Tumors
- Oral health in cancer treatment
- Lung Cancer Diagnosis and Treatment
- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Escherichia coli research studies
- Antibiotic Resistance in Bacteria
- Immune Response and Inflammation
- Lung Cancer Research Studies
- Cancer Diagnosis and Treatment
- Radiopharmaceutical Chemistry and Applications
- Radiomics and Machine Learning in Medical Imaging
- Neutropenia and Cancer Infections
- Hematopoietic Stem Cell Transplantation
- Oral and Maxillofacial Pathology
- Effects of Radiation Exposure
- Sepsis Diagnosis and Treatment
- melanin and skin pigmentation
- Pneumonia and Respiratory Infections
Heidelberger Institut für Radioonkologie
2018-2024
Heidelberg University
2018-2024
National Center for Tumor Diseases
2019-2024
University Hospital Heidelberg
2018-2024
German Cancer Research Center
2019-2024
Deutschen Konsortium für Translationale Krebsforschung
2019-2024
Asklepios Fachklinikum Brandenburg
2024
Helios Hospital Berlin-Buch
2003-2023
German Organ Transplantation Foundation
2020
ORCID
2020
This study describes neuropsychiatric side effects in patients after treatment with mefloquine. Reactions consisted mainly of seizures, acute psychoses, anxiety neurosis, and major disturbances sleep-wake rhythm. Side occurred both therapeutic prophylactic intake were graded from moderate to severe. In a risk analysis Germany, it is estimated that one 8,000 mefloquine users suffers such reactions. The incidence calculation revealed 215 had reactions, compared 13,000 the prophylaxis group,...
ABSTRACT When given in the presence of gamma interferon (IFN-γ), otherwise nontoxic doses lipopolysaccharide (LPS or endotoxin) become highly lethal for mice. The mechanisms this synergistic toxicity are not known. We considered possibility that an interaction between LPS-induced NF-κB and IFN-γ-induced JAK-STAT pathways at pretranscriptional level may enhance signals. To test hypothesis, we incubated murine macrophage RAW 264.7 cells with IFN-γ 2 h before addition different LPS. Consistent...
Fibroblast Activation Protein (FAP)-specific Positron Emission Tomography (PET) has shown promising results in various cancers. This pilot study compares FAP-specific PET to MRI for treatment planning 13 Glioblastoma patients. The resulting incongruent volumes could provide additional information radiotherapy or biopsy planning.
Abstract Background We set out to investigate how the ongoing coronavirus pandemic affected size of tumors and duration treatment delay in patients with surgically treated oral squamous cell carcinoma. Methods Patients cavity carcinoma were assessed retrospectively divided into two groups depending on when they had first presented at our clinic. presenting from 2010 2019, that is, before COVID‐19 onset ( n = 566) compared 2020 58). Results A total 624 included. Treatment was significantly...
Purpose To explore the benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy (MRgSBRT) for treatment lung tumors in different locations with a focus on ultracentral (ULT). Patients & Methods A prospective cohort 21 patients 23 primary and secondary was analyzed. Tumors were located peripherally (N = 10), centrally 2) ultracentrally 11, planning target volume (PTV) overlap proximal bronchi, esophagus and/or pulmonary artery). All received MRgSBRT gated dose...
Summary Background Bronchial asthma is characterized by chronic airway inflammation and remodelling which occurs in both proximal distal airways. These changes are associated with development of hyper‐responsiveness airflow limitation. Objective This study was aimed to analyse whether inhalative allergen challenges mice lead morphological physiological comparable this phenotype. Methods For purpose, BALB/c were systemically sensitized ovalbumin (OVA) followed aerosol on 2 consecutive days...
Abstract The anti-LPS antibody content of commercial intravenous immunoglobulins was examined by quantitative ELISA using LPS preparations from Escherichia coli, Klebsiella and Pseudomonas aeruginosa O serotypes occurring most frequently in Gram-negative septicaemia. Three IgG products different manufacturers one IgM-enriched product were tested. Mean levels significantly higher the IgM fraction compared with ‘pure’ products, indicating that natural antibodies against bacterial belong...
Abstract Objectives Osteoradionecrosis (ORN) of the lower jaw is a serious late complication after radiotherapy in patients with oral cavity cancer. The aim this study to generate more insight into which patient- and treatment-related factors are associated development ORN cancer undergoing postoperative radiotherapy. Material methods Retrospective evaluation comparison 44 (event group 1) matched according 45 without (control 2) who received squamous cell carcinoma at our institution between...
Abstract Neutropenia and agranulocytosis (N&A) are relatively rare, but potentially fatal adverse drug reactions (ADR). This study presents cases of N&A related to one or more antipsychotic drugs (APDs) in psychiatric inpatients. Data on APD utilization reports caused by APDs were analyzed using data from an observational pharmacovigilance program German-speaking countries—Arzneimittelsicherheit der Psychiatrie (AMSP)—from 1993 2016. 333,175 inpatients treated with for schizophrenia...
ABSTRACT A combined PCR assay was developed for the detection and typing of human polyomavirus (huPoV) in clinical samples, consisting (i) a qualitative seminested (snPCR) to discriminate between huPoV BK JC (ii) high-throughput, quantitative TaqMan (TM-PCR) general huPoV. The TM-PCR detects DNA linear range from 10 7 1 copies per assay. In reproducibility runs, inter- intra-assay variabilities were ≤60 ≤50%, respectively. snPCR uses set four primers same region viral genomes. first round...
Postoperative radiotherapy can improve locoregional control (LC) in oral cavity squamous cell carcinoma (OCSCC) patients with positive resection margins. The present study aimed to evaluate the impact of surgical margin size on LC this patient population.
To provide a database for the development of an O-antigen-polysaccharide-containing vaccine against Klebsiella spp., we examined O-antigen seroepidemiology 378 clinical isolates collected prospectively in two university centers. Strains were typed by competitive enzyme-linked immunosorbent assay with rabbit antisera specific serogroups O1 to O12 and monoclonal antibodies (MAbs) O1, O2ab, O2ac, genus-specific core antigen. The numbers (percentages) individual O as follows: 148 (39.2)...
The O antigen is both a major structural outer membrane component and the dominant epitope of most gram-negative bacteria. Pseudomonas aeruginosa 1244 produces type IV pilus covalently links an O-antigen repeating unit to each pilin monomer. Here we show that immunization mice with pure from strain by use either mouse respiratory model or thermal injury resulted in protection challenge pilus-null O-antigen-producing mutant. These results provide evidence glycan stimulates protective response...
We aimed to evaluate the treatment outcome of primary and postoperative bimodal radiotherapy (RT) including intensity modulated photon (IMRT) carbon ion (CIRT) for sinonasal adenoid cystic carcinoma (ACC) patients. Medical records 227 consecutive patients who received either a (n = 90, 40%) or 137, 60%; R2, n 86, 63%) IMRT with doses between 48 56 Gy in 1.8 2 fractions active raster-scanning boost 18 24 (RBE, relative biological effectiveness) 3 (RBE) 2009 2019 up median total dose 80 (EQD2,...
Proton beam radiotherapy (PRT) has been demonstrated to improve neurocognitive sequelae particularly. Nevertheless, following PRT, increased rates of radiation-induced contrast enhancements (RICE) are feared. How safe and effective is PRT for IDH-mutated glioma WHO grade 2 3?We analyzed 194 patients diagnosed with (n = 128) 3 66) who were treated from 2010 2020. Serial clinical imaging follow-up was performed a median 5.1 years.For 2, 61% astrocytoma 39% oligodendroglioma while 3, 55% 45%...