A5084960047- Brain Metastases and Treatment
- Glioma Diagnosis and Treatment
- Meningioma and schwannoma management
- Advanced Radiotherapy Techniques
- Radiation Therapy and Dosimetry
- Lung Cancer Diagnosis and Treatment
- Lung Cancer Research Studies
- Lung Cancer Treatments and Mutations
- Head and Neck Cancer Studies
- Neurofibromatosis and Schwannoma Cases
- Medical Imaging Techniques and Applications
- Advanced MRI Techniques and Applications
- Radiomics and Machine Learning in Medical Imaging
- Effects of Radiation Exposure
- Sarcoma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Oral health in cancer treatment
- Soft tissue tumor case studies
- Cerebrovascular and Carotid Artery Diseases
- Nanoplatforms for cancer theranostics
- Atomic and Subatomic Physics Research
- Neurological Disorders and Treatments
- Lanthanide and Transition Metal Complexes
- Medical Imaging and Pathology Studies
- Management of metastatic bone disease
University Hospital Heidelberg
2020-2025
Heidelberg University
2020-2025
National Center for Tumor Diseases
2020-2024
Heidelberger Institut für Radioonkologie
2020-2024
German Cancer Research Center
2024
Universitätsklinik für Strahlentherapie
2023
European Organisation for Research and Treatment of Cancer
2022
Purpose To explore the benefit of adaptive magnetic resonance-guided stereotactic body radiotherapy (MRgSBRT) for treatment lung tumors in different locations with a focus on ultracentral (ULT). Patients & Methods A prospective cohort 21 patients 23 primary and secondary was analyzed. Tumors were located peripherally (N = 10), centrally 2) ultracentrally 11, planning target volume (PTV) overlap proximal bronchi, esophagus and/or pulmonary artery). All received MRgSBRT gated dose...
Surgery for recurrent glioma provides cytoreduction and tissue molecularly informed treatment. With mostly heavily pretreated patients involved, it is unclear whether the benefits of repeat surgery outweigh its potential risks.
Abstract Allogeneic hematopoietic cell transplantation (alloHCT) is an effective treatment for patients with relapsed/refractory peripheral T-cell lymphoma (PTCL), but the contribution of conditioning regimen still unclear. Here we present a retrospective single-center study using intermediate-dose total body irradiation (TBI) and fludarabine alloHCT in PTCL. Forty-seven underwent PTCL between 2010 2023 after TBI (8 Gy 87% cases). In most was administered as part second-line therapy, 22...
Background and Purpose After surgical resection of brain metastases (BM), radiotherapy (RT) is indicated. Postoperative stereotactic radiosurgery (SRS) reduces the risk local progression neurocognitive decline compared to whole (WBRT). Aside from optimal dose fractionation, little known about combination systemic therapy postoperative fractionated (fSRT), especially regarding tumour control toxicity. Methods In this study, 105 patients receiving fSRT with 35 Gy in 7 fractions performed...
The PACIFC trial demonstrated a significant benefit of durvalumab consolidation immunotherapy (CIT) after definitive platinum-based chemoradiotherapy (P-CRT) for survival in stage III non-small cell lung cancer (NSCLC). It is unknown how many patients are eligible clinical practice to receive CIT according PACIFIC criteria compared real administration rates and what influencing factors are.We analyzed 442 with unresectable NSCLC who received P-CRT between 2009 2019 regarding eligibility...
Proton beam radiotherapy (PRT) has been demonstrated to improve neurocognitive sequelae particularly. Nevertheless, following PRT, increased rates of radiation-induced contrast enhancements (RICE) are feared. How safe and effective is PRT for IDH-mutated glioma WHO grade 2 3?We analyzed 194 patients diagnosed with (n = 128) 3 66) who were treated from 2010 2020. Serial clinical imaging follow-up was performed a median 5.1 years.For 2, 61% astrocytoma 39% oligodendroglioma while 3, 55% 45%...
The appearance of radiation-induced contrast enhancements (RICE) after radiotherapy for brain metastases can go along with severe neurological impairments. aim our analysis was to evaluate radiological changes, the course and recurrence RICE identify associated prognostic factors.We retrospectively identified patients diagnosed metastases, who were treated subsequently developed RICE. Patient demographic clinical data, radiation-, cancer-, RICE-treatment, results, oncological outcomes...
Abstract Background The current World Health Organization (WHO) classification of brain tumors distinguishes 3 malignancy grades in meningiomas, with increasing risk recurrence from CNS WHO 1 to 3. Radiotherapy is recommended by EANO guidelines for patients not safely amenable surgery or after incomplete resection higher grades. Despite adequately predicting probability the majority grade 2 meningioma patients, a considerable subset demonstrates an unexpectedly early tumor following...
Abstract Background Novel radiotherapeutic modalities using carbon ions provide an increased relative biological effectiveness (RBE) compared to photons, delivering a higher dose while reducing radiation exposure for adjacent organs. This prospective phase 2 trial investigated bimodal radiotherapy photons with carbon-ion (C12)-boost in patients WHO grade meningiomas following subtotal resection (Simpson 4 or 5). Methods A total of 33 were enrolled from July 2012 until 2020. The study...
•Upfront LT delay intracranial progression, but do not prolong OS in oncogene-driven NSCLC.•Use of stereotactic versus whole-brain radiotherapy and primary tumor TP53 status significantly affect brain control.•Non-del19 EGFR mutations 'short' EML4-ALK fusions are independent predictors earlier failure. BackgroundThe improved efficacy tyrosine kinase inhibitors (TKI) mandates reappraisal local therapy (LT) for metastases (BM) non-small-cell lung cancer (NSCLC).Patients methodsThis study...
Introduction: Following the resection of brain metastases (BM), whole-brain radiotherapy (WBRT) is a long-established standard care. Its position was recently challenged by less toxic single-session radiosurgery (SRS) or fractionated stereotactic (FSRT) cavity, reducing dose exposure healthy brain. Patients and methods: We analyzed 101 patients treated with either SRS/FSRT (n=50) WBRT (n=51) following BM over 5-year period. Propensity score adjustment done for age, total number BM, timepoint...
Pain, fatigue, and depression are a common cluster of symptoms among cancer patients that impair quality life daily activities. We aimed to evaluate the burden rehabilitation return-to-work (RTW) rates. Tumor characteristics, lifestyle household details, treatment data, use in-house social services post-treatment inpatient rehabilitation, RTW were assessed for 424 women, diagnosed with cervical, uterine, or vaginal/vulvar cancer, receiving curative radio(chemo)therapy. Progression-free rate...
Abstract Introduction Re-irradiation is frequently performed in the era of precision oncology, but previous doses to organs-at-risk (OAR) must be assessed avoid cumulative overdoses. Stereotactic magnetic resonance-guided online adaptive radiotherapy (SMART) enables highly precise ablation tumors close OAR. However, OAR may change considerably during treatment, which complicates potential re-irradiation. We aimed compare baseline plan with different dose accumulation techniques inform...
Purpose: Recent experimental studies and clinical trial results might indicate that - at least for some indications continued use of the mechanistic model relative biological effectiveness (RBE) applied carbon ion therapy facilities in Europe several decades (LEM-I) may be unwarranted. We present a novel framework prostate cancer treatment planning tumor control probability (TCP) prediction based on modified microdosimetric kinetic (mMKM) particle therapy.Methods: Treatment plans 91 patients...
Abstract Background While surgical resection remains the primary treatment approach for symptomatic or growing meningiomas, radiotherapy represents an auspicious alternative in patients with meningiomas not safely amenable to surgery. Biopsies are often omitted light of potential postoperative neurological deficits, resulting a lack histological grading and (molecular) risk stratification. In this prospective explorative biomarker study, extracellular vesicles bloodstream will be...