A5039168411- Radiation Therapy and Dosimetry
- Advanced Radiotherapy Techniques
- Radiation Effects in Electronics
- Radiation Detection and Scintillator Technologies
- Nuclear Physics and Applications
- Medical Imaging Techniques and Applications
- Boron Compounds in Chemistry
- Advanced X-ray and CT Imaging
- Nuclear reactor physics and engineering
- Effects of Radiation Exposure
- Glioma Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Head and Neck Cancer Studies
- Anesthesia and Neurotoxicity Research
- Medical Imaging and Pathology Studies
- Radiation Dose and Imaging
- Nonmelanoma Skin Cancer Studies
- DNA Repair Mechanisms
- Radiomics and Machine Learning in Medical Imaging
- Bone Tumor Diagnosis and Treatments
- Advances in Oncology and Radiotherapy
- Radiation Effects and Dosimetry
- Meningioma and schwannoma management
- Lung Cancer Diagnosis and Treatment
- Radiation Shielding Materials Analysis
Heidelberg University
2015-2024
University Hospital Heidelberg
2015-2024
Heidelberger Institut für Radioonkologie
2016-2024
German Cancer Research Center
2022-2024
National Center for Tumor Diseases
2022-2024
Centre François Baclesse
2018-2020
Université de Caen Normandie
2019-2020
Normandie Université
2019-2020
Employment Agency
2019
Centre Oscar Lambret
2019
onte Carlo (MC) codes are increasingly spreading in the hadrontherapy community due to their detailed description of radiation transport and interaction with matter. The suitability a MC code for application demands accurate reliable physical models capable handling all components expected field. This becomes extremely important correctly performing not only but also biologically-based dose calculations, especially cases where ions heavier than protons involved. In addition, prediction...
In proton radiation therapy a constant relative biological effectiveness (RBE) of 1.1 is usually assumed. However, experiments have evidenced RBE dependencies on dose level, linear energy transfer (LET) and tissue type. This work compares the predictions three main radio-biological models proposed in literature by Carabe-Fernandez, Wedenberg, Scholz coworkers. Using chosen models, spread-out Bragg peak (SOBP) as well two exemplary clinical cases (single field fields) for cranial irradiation,...
In the field of radiotherapy, Monte Carlo (MC) particle transport calculations are recognized for their superior accuracy in predicting dose and fluence distributions patient geometries compared to analytical algorithms which generally used treatment planning due shorter execution times. this work, a newly developed MC-based (MCTP) tool proton therapy is proposed support studies research applications. It allows single-field simultaneous multiple-field optimization realistic scenarios based...
Purpose: Dual energy CT (DECT) has recently been proposed as an improvement over single (SECT) for stopping power ratio (SPR) estimation proton therapy treatment planning (TP), thereby potentially reducing range uncertainties. Published literature investigated phantoms. This study aims at performing TP on SECT and DECT head images of the same patients evaluating whether reported improved SPR accuracy translates into clinically relevant shifts in clinical scenarios. Methods: Two phantoms were...
Purpose: Modern facilities for actively scanned ion beam radiotherapy allow in principle the use of helium beams, which could present specific advantages, especially pediatric tumors. In order to assess potential these beams radiotherapy, i.e., create realistic treatment plans, authors set up a dedicated 4 He model, providing base data their planning system TRiP98, and they have reported that this work together with its physical biological validations. Methods: A semiempirical model depth...
PurposeTo investigate brain tissue response to ultra-high dose rate (uHDR, FLASH) and standard (SDR) proton irradiations in the Bragg peak region.Methods MaterialsActive scanning uHDR delivery was established for beams investigation of effects between clinical SDR at ∼10 Gy region (dose-averaged linear energy transfer [LETD] ranging from 4.5 10.2 keV µm-1 ). Radiation- induced injury neuronal assessed by studying DNA double strand break repair kinetics surrogated nuclear γH2AX staining...
Helium ions offer intermediate physical and biological properties to the clinically used protons carbon ions. This work presents commissioning of first clinical treatment planning system (TPS) for helium ion therapy with active beam delivery prepare patients' at Heidelberg Ion-Beam Therapy Center (HIT).Through collaboration between RaySearch Laboratories HIT, absorbed relative effectiveness (RBE)-weighted calculation methods were integrated raster-scanned in TPS RayStation. At a modified...
The growing number of particle therapy facilities worldwide landmarks a novel era precision oncology. Implementation robust biophysical readouts is urgently needed to assess the efficacy different radiation qualities. This first report on evaluation Monte Carlo simulated predictive models prescribed dose for four qualities i.e., proton, helium-, carbon- or oxygen ions using raster-scanning technology and clinical settings at HIT. A high level agreement was found between in silico...
During one year of clinical activity at the Italian National Center for Oncological Hadron Therapy 31 patients were treated with actively scanned proton beams. Results patient-specific quality assurance procedures are presented here which assess accuracy a three-dimensional dose verification technique simultaneous use multiple small-volume ionization chambers. To investigate critical cases major deviations between treatment planning system (TPS) calculated and measured data points, Monte...
At the Heidelberg Ion Beam Therapy Center, scanned helium and oxygen ion beams are available in addition to clinically used protons carbon ions for physical biological experiments. In this work, a study of basic dosimetric features different is performed entire therapeutic energy range. Depth dose distributions investigated pencil-like beam irradiation, with without modulating ripple filter, focusing on extraction key Bragg curve parameters, such as range, peak-width distal 80%–20% fall-off....
Treatment planning studies on the biological effect of raster-scanned helium ion beams should be performed, together with their experimental verification, before clinical application at Heidelberg Ion Beam Therapy Center (HIT). For this purpose, we introduce a novel calculation approach based integrating data-driven models in our Monte Carlo treatment (MCTP) tool. Dealing mixed radiation field, primary 4He beams, secondary 3He and (Z = 2) fragments produced protons, deuterons tritons 1) has...
Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks reduced lateral scattering. Consequently, the potential clinical benefit of both techniques was explored. An explorative treatment planning study involving ten patients, previously treated with VMAT (Volumetric Modulated Arc Therapy) 50 Gy in 25 fractions locally advanced, node-positive cancer, carried out using proton...
Monte Carlo (MC) simulations of beam interaction and transport in matter are increasingly considered as essential tools to support several aspects radiation therapy. Despite the vast application MC photon therapy scattered proton therapy, clinical experience scanned ion is still scarce. This especially case for ions heavier than protons, which pose additional issues like nuclear fragmentation varying biological effectiveness. In this work, we present evaluation a dedicated framework has been...
Due to their favorable physical and biological properties, helium ion beams are increasingly considered a promising alternative proton for radiation therapy. Hence, this work aims at comparing in-silico the treatment of brain ocular meningiomas with protons ions, using first time dedicated Monte Carlo (MC) based planning engine (MCTP) thoroughly validated both in terms models. Starting from clinical plans four patients undergoing therapy fixed relative effectiveness (RBE) 1.1 fraction dose...
Proton computed tomography (pCT) is a promising imaging technique to substitute or at least complement x-ray CT for more accurate proton therapy treatment planning as it allows calculating directly relative stopping power from energy loss measurements. A scanner with silicon-based particle tracking system and five-stage scintillating detector has been completed. In parallel modular software platform was developed characterize the performance of proposed pCT.The pCT consists (1) Geant4-based...
Radiotherapy with protons and heavier ions landmarks a novel era in the field of high-precision cancer therapy. To identify patients most benefiting from this technologically demanding therapy, fast assessment comparative treatment plans utilizing different ion species is urgently needed. Moreover, to overcome uncertainties actual in-vivo physical dose distribution biological effects elicited by radiation qualities, development reliable high-throughput algorithm required. end, we engineered...
Proton therapy treatment planning systems (TPSs) are based on the assumption of a constant relative biological effectiveness (RBE) 1.1 without taking into account found in vitro experimental variations RBE as function tissue type, linear energy transfer (LET) and dose. The phenomenological models available literature dose-averaged LET (LETD) an indicator physical properties proton radiation field. LETD values typically calculated primary secondary protons, neglecting effect heavier...
The introduction of 'new' ion species in particle therapy needs to be supported by a thorough assessment their dosimetric properties and treatment planning comparisons with clinically used proton carbon beams. In addition the latter two ions, helium oxygen beams are foreseen at Heidelberg Ion Beam Therapy Center (HIT) as potential assets for improving clinical outcomes near future. We present this study validation FLUKA-based Monte Carlo tool (MCTP) protons, helium, ions spread-out Bragg...
Helium (
PurposeTo evaluate the clinical potential of spot-scanning hadron arc (SHArc) therapy with a heavy-ion gantry.Methods and MaterialsA series in silico studies was conducted via treatment plan optimization FRoG RayStation TPS to compare SHArc against reference plans using conventional techniques single, parallel-opposed, 3-field configurations for 3 particle beams (protons [p], helium [4He], carbon [12C] ions). Tests were performed on water-equivalent cylindrical phantoms simple targets...