A5090767286- Dementia and Cognitive Impairment Research
- Blood Pressure and Hypertension Studies
- Nutritional Studies and Diet
- Health Systems, Economic Evaluations, Quality of Life
- Frailty in Older Adults
- Gestational Diabetes Research and Management
- Nutrition and Health in Aging
- Cardiovascular Health and Disease Prevention
- Heart Rate Variability and Autonomic Control
- Diet and metabolism studies
- Cardiovascular Syncope and Autonomic Disorders
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Sodium Intake and Health
- Cervical Cancer and HPV Research
- Diabetes Management and Research
- Cardiac Health and Mental Health
- Alzheimer's disease research and treatments
- Birth, Development, and Health
- Health disparities and outcomes
- Cancer Risks and Factors
- Pharmaceutical Practices and Patient Outcomes
- Hormonal Regulation and Hypertension
- Diabetes Treatment and Management
- Aging and Gerontology Research
- Health and Well-being Studies
Imperial College London
2016-2025
UNSW Sydney
2018-2025
The George Institute for Global Health
2019-2025
Neuroscience Research Australia
2018-2024
Dementia Collaborative Research Centres
2016-2023
Union Bank of Switzerland
2023
The University of Sydney
2023
Monash Health
2023
Alzheimer’s Disease Neuroimaging Initiative
2023
Tergooi
2020-2021
Whether the treatment of patients with hypertension who are 80 years age or older is beneficial unclear. It has been suggested that antihypertensive therapy may reduce risk stroke, despite possibly increasing death.We randomly assigned 3845 from Europe, China, Australasia, and Tunisia were had a sustained systolic blood pressure 160 mm Hg more to receive either diuretic indapamide (sustained release, 1.5 mg) matching placebo. The angiotensin-converting-enzyme inhibitor perindopril (2 4 mg),...
Type 2 diabetes frequently results from progressive failure of pancreatic β-cell function in the presence chronic insulin resistance. We tested whether amelioration resistance would preserve and delay or prevent onset type high-risk Hispanic women. Women with previous gestational were randomized to placebo (n = 133) insulin-sensitizing drug troglitazone (400 mg/day; n administered double-blind fashion. Fasting plasma glucose was measured every 3 months, oral tolerance tests (OGTTs) performed...
BackgroundObservational epidemiological studies have shown a positive association between hypertension and risk of incident dementia; however, the effects antihypertensive therapy on cognitive function in controlled trials been conflicting, meta-analyses not provided clear evidence whether treatment reduces dementia incidence. The Hypertension Very Elderly trial (HYVET) was designed to assess risks benefits elderly patients included an assessment function.MethodsPatients with (systolic...
Colorectal cancer is a major public health problem in both North America and western Europe, incidence mortality rates are rapidly increasing many previously low-risk countries. It has been hypothesized that increased intakes of fiber, vitamin C, beta carotene could decrease the risk colorectal cancer.The objective this study was to examine effects beta-carotene on combined analysis data from 13 case-control studies conducted populations with differing dietary practices. The designed...
The Pioglitazone In Prevention Of Diabetes (PIPOD) study was conducted to evaluate β-cell function, insulin resistance, and the incidence of diabetes during treatment with pioglitazone in Hispanic women prior gestational who had completed participation Troglitazone (TRIPOD) study. Women TRIPOD were offered PIPOD for a planned 3 years drug 6 months postdrug washout. Oral glucose tolerance tests performed annually on at end Intravenous (IVGTTs) assessment sensitivity function baseline, after 1...
Abstract Aims The aim of this study was to derive and validate the SCORE2-Older Persons (SCORE2-OP) risk model estimate 5- 10-year cardiovascular disease (CVD) in individuals aged over 70 years four geographical regions. Methods results Sex-specific competing risk-adjusted models for estimating CVD (CVD mortality, myocardial infarction, or stroke) were derived 65 without pre-existing atherosclerotic from Cohort Norway (28 503 individuals, 10 089 events). Models included age, smoking status,...
Treatment for hypertension with antihypertensive medication has been shown to reduce stroke, cardiovascular events, and mortality in older adults, but there is concern that such treatment may not be appropriate frailer adults. To investigate whether an interaction between effect of frailty we calculated the index (FI) all available participants from HYpertension Very Elderly Trial (HYVET) study, a double-blind, placebo-controlled study antihypertensives people aged 80 over, obtained adjusted...
With population ageing worldwide, dementia poses one of the greatest global challenges for health and social care in 21st century. In 2019, around 55 million people were affected by dementia, with majority living low- middle-income countries. Dementia leads to increased costs governments, communities, families individuals. is overwhelming family caregivers person who are cornerstone support systems throughout world. To assist countries addressing burden World Health Organisation (WHO)...
Abstract The associations between methods of cooking meats and colorectal cancer were examined in a population‐based case‐ referent study performed Stockholm 1986‐1988. included 559 cases 505 referents. Total meat intake, frequent consumption brown gravy, preference for heavily browned surface each independently increased the risk cancer. relative risks (RR) higher rectal than colon cancer, boiled (RR = 1.7, RR rectum 2.7) fried with medium or lightly 0.8, 1.1), but highest 2.8, 6.0)....
It has been known for more than 20 years that estrogen replacement therapy substantially increases a woman's risk of developing endometrial cancer. To reduce this increased risk, progestins have added to between 5 and 15 days (usually 7 or 10 days) per "month" in sequential fashion (sequential estrogen-progestin therapy) with each dose (continuous combined therapy). At the present time, however, little is about effects varying number progestin used therapy.We sought determine continuous on...
Background The risks and benefits of treating hypertension in individuals older than 80 years are uncertain. A meta-analysis has suggested that a reduction stroke events 36% may have to be balanced against 14% increase total mortality. Objectives To report the results pilot study Hypertension Very Elderly Trial (HYVET), which is progress address these issues. Methods HYVET-Pilot was multicentre international open trial. In 10 European countries, 1283 patients with sustained blood pressure...