A5066609936- Neurotransmitter Receptor Influence on Behavior
- Receptor Mechanisms and Signaling
- Tryptophan and brain disorders
- Neuroscience and Neuropharmacology Research
- Folate and B Vitamins Research
- Neural dynamics and brain function
- Neuroinflammation and Neurodegeneration Mechanisms
- Neuroendocrine regulation and behavior
- Stress Responses and Cortisol
- Birth, Development, and Health
- RNA modifications and cancer
- Genetics and Neurodevelopmental Disorders
- Nuclear Receptors and Signaling
- Neuropeptides and Animal Physiology
- Pancreatic function and diabetes
- Memory and Neural Mechanisms
- Cardiac electrophysiology and arrhythmias
- Cardiac Arrhythmias and Treatments
- Visual perception and processing mechanisms
- Obesity, Physical Activity, Diet
- Genetics, Aging, and Longevity in Model Organisms
- Breastfeeding Practices and Influences
- Diet and metabolism studies
- Epilepsy research and treatment
- Adipose Tissue and Metabolism
National Comprehensive Cancer Network
2024-2025
Allen Institute for Brain Science
2018-2025
Icahn School of Medicine at Mount Sinai
2017-2025
Drexel University
2022-2025
Duke Medical Center
2021-2023
Comprehensive Blood & Cancer Center
2023
Hertie Institute for Clinical Brain Research
2022
University of Tübingen
2022
International Foundation for Integrated Care
2021-2022
University of British Columbia
2017-2021
Abstract Anxiety disorders are complex diseases, and often co-occur with depression. It is as yet unclear if a common neural circuit controls anxiety-related behaviors in both anxiety-alone comorbid conditions. Here, utilizing the chronic social defeat stress (CSDS) paradigm that induces singular or combined anxiety- depressive-like phenotypes mice, we show ventral tegmental area (VTA) dopamine projecting to basolateral amygdala (BLA) selectively but not depression-like behaviors. Using...
The NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease provide strategies the prevention, diagnosis, and treatment of venous thromboembolism (VTE) in adult patients with cancer. VTE is a common life-threatening condition cancer, its management often requires multidisciplinary efforts. panel comprised specialists spanning various fields, including cardiology, hematology, medical oncology, internal medicine, interventional radiology, pharmacology. content featured this issue...
This selection from the NCCN Guidelines for Adolescent and Young Adult (AYA) Oncology focuses on considerations comprehensive care of AYA patients with cancer. Compared older adults cancer, have unique needs regarding treatment, fertility counseling, psychosocial behavioral issues, supportive services. The complete version addresses additional aspects caring patients, including risk factors, screening, diagnosis, survivorship.
The NCCN Guidelines for Head and Neck Cancers address tumors arising in the oral cavity (including mucosal lip), pharynx, larynx, paranasal sinuses, as well occult primary cancer, salivary gland melanoma (MM). specific site of disease, stage, pathologic findings guide treatment (eg, appropriate surgical procedure, radiation targets, dose fractionation radiation, indications systemic therapy). Panel meets at least annually to review comments from reviewers within their institutions, examine...
Alcohol-use disorder (AUD) is the most prevalent substance-use worldwide. There substantial individual variability in alcohol drinking behaviors population, neural circuit mechanisms of which remain elusive. Utilizing vivo electrophysiological techniques, we find that low (LAD) mice have dramatically higher ventral tegmental area (VTA) dopamine neuron firing and burst activity. Unexpectedly, VTA activity high (HAD) does not differ from naive mice. Optogenetically enhancing HAD decreases...
SUMMARYCardiovascular diseases are a major comorbidity factor in Type 2 diabetes patients and leading cause of death among them. Yet, mechanistically, how impairment pancreatic islets alters cardiac function under different metabolic states remains largely unknown. Here, we investigate the role G-protein coupled receptor kinase (GRK2) regulating islet adaptations to an obesogenic diet its impact on myocardial function. Using novel inducible β-cell specific GRK2 knockout mouse model...
Major Depressive Disorder (MDD) is a devastating, multifactorial disease with limited pharmacological treatment options. Patients MDD exhibit alterations in their dopamine (DA) signaling pathways through the midbrain ventral tegmental area (VTA). A similar observation also detected preclinical models of stress - mice behavioral and physiological impairments following chronic social defeat (CSDS). Prior studies demonstrate that CSDS-susceptible have increased VTA DA neuronal excitability,...
The NCCN Guidelines for Testicular Cancer provide recommendations the multidisciplinary approach to diagnostic workup, treatment, and follow-up testicular germ cell tumors, including both seminoma nonseminoma. These Insights discuss current treatment supporting clinical data seminomas as presented in Version 2.2025 of Cancer.
Several lines of evidence support a critical role TLR4 in the neuroimmune responses associated with alcohol disorders and propose inhibitors signaling as potential treatments for alcoholism. In this work, we investigated effect T5342126 compound, selective inhibitor, on excessive drinking microglial activation ethanol dependence.We used 2BC-CIE (two-bottle choice-chronic intermittent vapor exposure) paradigm to induce dependence mice. After induction dependence, injected (i.p., 57 mg/kg) 14...
<h3>Background and Objectives</h3> <i>KCNC2</i> encodes Kv3.2, a member of the Shaw-related (Kv3) voltage-gated potassium channel subfamily, which is important for sustained high-frequency firing optimized energy efficiency action potentials in brain. The objective this study was to analyze clinical phenotype, genetic background, biophysical function disease-associated Kv3.2 variants. <h3>Methods</h3> Individuals with variants detected by exome sequencing were selected clinical, further...
Non-communicable disease (NCD) prevention and care in humanitarian contexts has been a long-neglected issue. Healthcare systems settings have focused heavily on communicable diseases immediate life-saving health needs. NCDs are significant cause of morbidity mortality refugee settings, however, many situations NCD is not well integrated into primary healthcare services. Increased risk poorer outcomes from COVID-19 for people living with heightened the urgency responding to shone spotlight...