A5047278765- Immunotherapy and Immune Responses
- Immune cells in cancer
- Cancer Immunotherapy and Biomarkers
- T-cell and B-cell Immunology
- Cell Adhesion Molecules Research
- Histone Deacetylase Inhibitors Research
- Neuroblastoma Research and Treatments
- Epigenetics and DNA Methylation
- Mathematical Biology Tumor Growth
- Virus-based gene therapy research
- Chemotherapy-induced cardiotoxicity and mitigation
- Venous Thromboembolism Diagnosis and Management
- Alzheimer's disease research and treatments
- Drug Transport and Resistance Mechanisms
- Monoclonal and Polyclonal Antibodies Research
- Wnt/β-catenin signaling in development and cancer
- Pancreatic and Hepatic Oncology Research
- Protein Degradation and Inhibitors
- Protein Kinase Regulation and GTPase Signaling
- Melanoma and MAPK Pathways
- Peptidase Inhibition and Analysis
- Cell death mechanisms and regulation
- Cancer Genomics and Diagnostics
- Cardiac tumors and thrombi
- Lung Cancer Research Studies
National Comprehensive Cancer Network
2024
Nebraska Medical Center
2017-2022
University of Nebraska Medical Center
2016-2022
Fox Chase Cancer Center
2021
The NCCN Guidelines for Cancer-Associated Venous Thromboembolic Disease provide strategies the prevention, diagnosis, and treatment of venous thromboembolism (VTE) in adult patients with cancer. VTE is a common life-threatening condition cancer, its management often requires multidisciplinary efforts. panel comprised specialists spanning various fields, including cardiology, hematology, medical oncology, internal medicine, interventional radiology, pharmacology. content featured this issue...
The histone deacetylase (HDAC) inhibitor vorinostat, used with gemcitabine and other therapies, has been effective in treatment of experimental models pancreatic cancer. In this study, we demonstrated that M344, an HDAC inhibitor, is efficacious against cancer vitro vivo , alone or gemcitabine. By 24 hours post-treatment, M344 augments the population cells G 1 at a later time point (48 hours) it increases apoptosis. inhibits H3 deacetylation slows cell proliferation better than does not...
Beta 2-microglobulin (β2m) is a component of the major histocompatibility complex (MHC) class I molecule, which presents tumor antigens to T lymphocytes trigger cancer cell destruction. Notably, β2m has been reported as persistently expressed, rather than down regulated, in some types. For renal and oral squamous carcinomas, expression linked increased migratory capabilities. The ability pancreatic cells contributes their metastatic tendencies lethal nature. Therefore, this study, we...
Abstract Background: Cancer is a devastating scourge, causing morbidity and mortality in both adult pediatric populations. In this study, we analyzed the effects of histone deacetylase (HDAC) inhibitors on MHC class I expression, growth, migration cancer cells. Within cells, molecules bind to fragments tumor-associated peptides, then migrate cell surface present peptides T lymphocytes induce lysis tumor thereby preventing further spread malignancy. Pancreatic cancer, disease afflicting older...
Abstract Recent studies in transplantation models have implicated HLA class I molecules as important factors activating downstream pathways that lead to cell proliferation and migration. In a few cancers, β2m alone has been proposed be high expression increase No research date reported if and/or the heavy chain promote migration of pancreatic cancer cells and, so, whether work together or separate entities within signaling these processes. Using cells, we demonstrate siRNA knockdown causes...
Abstract Human leukocyte antigen (HLA) class I molecules are composed of a heavy chain with three isoforms (-A, -B, and –C) light (beta 2-microglobulin or β2m). These best known for their role within the immune system, in which they present antigens to cytotoxic T cells. have been found some tumor models be down regulated as form escape; however, recent studies breast, gastric, lung cancer correlated high expression levels HLA poorer patient prognosis. β2m has also many cancers, it...
Abstract Solid tumors demonstrate varying levels of immunogenic potential as well the proficiency to undergo immune evasion, thus there is a need for novel therapies capable augmenting patient’s anti-tumor response in concentrated and durable manner. We hypothesized that therapeutic modalities utilizing chemoattractant C-C motif chemokine ligand 21 (CCL21) alginate nanoformulation will provide prolonged release CCL21 subsequent steady infiltration cells into tumor, which abrogate disease...
Abstract Beta 2-microglublin (β2m) is a 12-kilodalton protein that serves as the non-covalently bound light chain in complex with major histocompability (MHC) class I heavy chain. The human MHC known leukocyte antigen (HLA), which exists three isotypes (HLA-A, -B, and -C). Much of function β2m regards to its role stabilizing HLA thereby helping present endogenous antigenic peptides cytotoxic T cells. Notably, has recently been found be elevated expression variety cancers, including renal...